Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer.
Sutherlin, D.P., Bao, L., Berry, M., Castanedo, G., Chuckowree, I., Dotson, J., Folks, A., Friedman, L., Goldsmith, R., Gunzner, J., Heffron, T., Lesnick, J., Lewis, C., Mathieu, S., Murray, J., Nonomiya, J., Pang, J., Pegg, N., Prior, W.W., Rouge, L., Salphati, L., Sampath, D., Tian, Q., Tsui, V., Wan, N.C., Wang, S., Wei, B., Wiesmann, C., Wu, P., Zhu, B.Y., Olivero, A.
J.Med.Chem.
