Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bowers, S., Truong, A.P., Jeffrey Neitz, R., Hom, R.K., Sealy, J.M., Probst, G.D., Quincy, D., Peterson, B., Chan, W., Galemmo, R.A., Konradi, A.W., Sham, H.L., Toth, G., Pan, H., Lin, M., Yao, N., Artis, D.R., Zhang, H., Chen, L., Dryer, M., Samant, B., Zmolek, W., Wong, K., Lorentzen, C., Goldbach, E., Tonn, G., Quinn, K.P., Sauer, J.M., Wright, S., Powell, K., Ruslim, L., Ren, Z., Bard, F., Yednock, T.A., Griswold-Prenner, I.
Bioorg.Med.Chem.Lett.
