PDB 3ptg

PDB Information

PDB3PTG
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bowers, S., Truong, A.P., Neitz, R.J., Neitzel, M., Probst, G.D., Hom, R.K., Peterson, B., Galemmo, R.A., Konradi, A.W., Sham, H.L., Toth, G., Pan, H., Yao, N., Artis, D.R., Brigham, E.F., Quinn, K.P., Sauer, J.M., Powell, K., Ruslim, L., Ren, Z., Bard, F., Yednock, T.A., Griswold-Prenner, I.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2010-12-02
Resolution2.430
CATH Insert Date06 Mar, 2011

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 06 Mar, 2011 Chopped
J 06 Mar, 2011 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
3ptgA01 10 Mar, 2011 3.30.200.20 Assigned
3ptgA02 10 Mar, 2011 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q9UQF2 JIP1_HUMAN Homo sapiens C-Jun-amino-terminal kinase-interacting protein 1
P53779 MK10_HUMAN Homo sapiens Mitogen-activated protein kinase 10
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