PDB 3pi5

PDB Information

PDB3PI5
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.
Rueeger, H., Rondeau, J.M., McCarthy, C., Mobitz, H., Tintelnot-Blomley, M., Neumann, U., Desrayaud, S.
Bioorg.Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2010-11-05
Resolution2.400
CATH Insert Date27 Mar, 2011

PDB Images (10)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 28 Mar, 2011 Chopped
B 28 Mar, 2011 Chopped
C 28 Mar, 2011 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
3pi5A01 01 Apr, 2011 2.40.70.10 Assigned
3pi5A02 01 Apr, 2011 2.40.70.10 Assigned
3pi5B01 01 Apr, 2011 2.40.70.10 Assigned
3pi5B02 01 Apr, 2011 2.40.70.10 Assigned
3pi5C01 01 Apr, 2011 2.40.70.10 Assigned
3pi5C02 01 Apr, 2011 2.40.70.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1