PDB Information

PDB3OG7
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Bollag, G., Hirth, P., Tsai, J., Zhang, J., Ibrahim, P.N., Cho, H., Spevak, W., Zhang, C., Zhang, Y., Habets, G., Burton, E.A., Wong, B., Tsang, G., West, B.L., Powell, B., Shellooe, R., Marimuthu, A., Nguyen, H., Zhang, K.Y., Artis, D.R., Schlessinger, J., Su, F., Higgins, B., Iyer, R., D'Andrea, K., Koehler, A., Stumm, M., Lin, P.S., Lee, R.J., Grippo, J., Puzanov, I., Kim, K.B., Ribas, A., McArthur, G.A., Sosman, J.A., Chapman, P.B., Flaherty, K.T., Xu, X., Nathanson, K.L., Nolop, K.
Nature
HeaderTransferase/Transferase Inhibitor
Released2010-08-16
Resolution2.450
CATH Insert Date26 Sep, 2010

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 27 Sep, 2010 Chopped
B 27 Sep, 2010 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
3og7A01 16 Feb, 2011 3.30.200.20 Assigned
3og7A02 16 Feb, 2011 1.10.510.10 Assigned
3og7B01 16 Feb, 2011 3.30.200.20 Assigned
3og7B02 16 Feb, 2011 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P15056 BRAF_HUMAN Homo sapiens Serine/threonine-protein kinase B-raf
P15056 BRAF_HUMAN Homo sapiens Serine/threonine-protein kinase B-raf
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