PDB 3mg8

PDB Links
Overview

PDB Information

PDB	3MG8
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit. Blackburn, C., Gigstad, K.M., Hales, P., Garcia, K., Jones, M., Bruzzese, F.J., Barrett, C., Liu, J.X., Soucy, T.A., Sappal, D.S., Bump, N., Olhava, E.J., Fleming, P., Dick, L.R., Tsu, C., Sintchak, M.D., Blank, J.L. Biochem.J.
Header	Hydrolase
Released	2010-04-05
Resolution	2.590
CATH Insert Date	22 May, 2011

PDB Images (57)

3mg8

PDB 3mg8

3mg81

PDB Chain 3mg81

3mg82

PDB Chain 3mg82

3mg8A

PDB Chain 3mg8A

3mg8B

PDB Chain 3mg8B

3mg8C

PDB Chain 3mg8C

3mg8D

PDB Chain 3mg8D

3mg8E

PDB Chain 3mg8E

3mg8F

PDB Chain 3mg8F

3mg8G

PDB Chain 3mg8G

3mg8H

PDB Chain 3mg8H

3mg8I

PDB Chain 3mg8I

3mg8J

PDB Chain 3mg8J

3mg8K

PDB Chain 3mg8K

3mg8L

PDB Chain 3mg8L

3mg8M

PDB Chain 3mg8M

3mg8N

PDB Chain 3mg8N

3mg8O

PDB Chain 3mg8O

3mg8P

PDB Chain 3mg8P

3mg8Q

PDB Chain 3mg8Q

3mg8R

PDB Chain 3mg8R

3mg8S

PDB Chain 3mg8S

3mg8T

PDB Chain 3mg8T

3mg8U

PDB Chain 3mg8U

3mg8V

PDB Chain 3mg8V

3mg8W

PDB Chain 3mg8W

3mg8X

PDB Chain 3mg8X

3mg8Y

PDB Chain 3mg8Y

3mg8Z

PDB Chain 3mg8Z

3mg8100

CATH Domain 3mg8100

3mg8200

CATH Domain 3mg8200

3mg8A00

CATH Domain 3mg8A00

3mg8B00

CATH Domain 3mg8B00

3mg8C00

CATH Domain 3mg8C00

3mg8D00

CATH Domain 3mg8D00

3mg8E00

CATH Domain 3mg8E00

3mg8F00

CATH Domain 3mg8F00

3mg8G00

CATH Domain 3mg8G00

3mg8H00

CATH Domain 3mg8H00

3mg8I00

CATH Domain 3mg8I00

3mg8J00

CATH Domain 3mg8J00

3mg8K00

CATH Domain 3mg8K00

3mg8L00

CATH Domain 3mg8L00

3mg8M00

CATH Domain 3mg8M00

3mg8N00

CATH Domain 3mg8N00

3mg8O00

CATH Domain 3mg8O00

3mg8P00

CATH Domain 3mg8P00

3mg8Q00

CATH Domain 3mg8Q00

3mg8R00

CATH Domain 3mg8R00

3mg8S00

CATH Domain 3mg8S00

3mg8T00

CATH Domain 3mg8T00

3mg8U00

CATH Domain 3mg8U00

3mg8V00

CATH Domain 3mg8V00

3mg8W00

CATH Domain 3mg8W00

3mg8X00

CATH Domain 3mg8X00

3mg8Y00

CATH Domain 3mg8Y00

3mg8Z00

CATH Domain 3mg8Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
1	23 May, 2011	Chopped
2	23 May, 2011	Chopped
A	23 May, 2011	Chopped
B	23 May, 2011	Chopped
C	23 May, 2011	Chopped
D	23 May, 2011	Chopped
E	23 May, 2011	Chopped
F	23 May, 2011	Chopped
G	23 May, 2011	Chopped
H	23 May, 2011	Chopped
I	23 May, 2011	Chopped
J	23 May, 2011	Chopped
K	23 May, 2011	Chopped
L	23 May, 2011	Chopped
M	23 May, 2011	Chopped
N	23 May, 2011	Chopped
O	23 May, 2011	Chopped
P	23 May, 2011	Chopped
Q	23 May, 2011	Chopped
R	23 May, 2011	Chopped
S	23 May, 2011	Chopped
T	23 May, 2011	Chopped
U	23 May, 2011	Chopped
V	23 May, 2011	Chopped
W	23 May, 2011	Chopped
X	23 May, 2011	Chopped
Y	23 May, 2011	Chopped
Z	23 May, 2011	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3mg8100	26 May, 2011	3.60.20.10	Assigned
3mg8200	26 May, 2011	3.60.20.10	Assigned
3mg8A00	04 Feb, 2013	3.60.20.10	Assigned
3mg8B00	04 Feb, 2013	3.60.20.10	Assigned
3mg8C00	04 Feb, 2013	3.60.20.10	Assigned
3mg8D00	08 Feb, 2013	3.60.20.10	Assigned
3mg8E00	26 May, 2011	3.60.20.10	Assigned
3mg8F00	27 May, 2011	3.60.20.10	Assigned
3mg8G00	27 May, 2011	3.60.20.10	Assigned
3mg8H00	26 May, 2011	3.60.20.10	Assigned
3mg8I00	26 May, 2011	3.60.20.10	Assigned
3mg8J00	27 May, 2011	3.60.20.10	Assigned
3mg8K00	26 May, 2011	3.60.20.10	Assigned
3mg8L00	27 May, 2011	3.60.20.10	Assigned
3mg8M00	27 May, 2011	3.60.20.10	Assigned
3mg8N00	27 May, 2011	3.60.20.10	Assigned
3mg8O00	04 Feb, 2013	3.60.20.10	Assigned
3mg8P00	04 Feb, 2013	3.60.20.10	Assigned
3mg8Q00	04 Feb, 2013	3.60.20.10	Assigned
3mg8R00	08 Feb, 2013	3.60.20.10	Assigned
3mg8S00	26 May, 2011	3.60.20.10	Assigned
3mg8T00	26 May, 2011	3.60.20.10	Assigned
3mg8U00	26 May, 2011	3.60.20.10	Assigned
3mg8V00	27 May, 2011	3.60.20.10	Assigned
3mg8W00	26 May, 2011	3.60.20.10	Assigned
3mg8X00	26 May, 2011	3.60.20.10	Assigned
3mg8Y00	26 May, 2011	3.60.20.10	Assigned
3mg8Z00	26 May, 2011	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5