PDB 3lzb

PDB Information

PDB3LZB
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
Fidanze, S.D., Erickson, S.A., Wang, G.T., Mantei, R., Clark, R.F., Sorensen, B.K., Bamaung, N.Y., Kovar, P., Johnson, E.F., Swinger, K.K., Stewart, K.D., Zhang, Q., Tucker, L.A., Pappano, W.N., Wilsbacher, J.L., Wang, J., Sheppard, G.S., Bell, R.L., Davidsen, S.K., Hubbard, R.D.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2010-03-01
Resolution2.700
CATH Insert Date06 Mar, 2011

PDB Images (17)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 06 Mar, 2011 Chopped
B 06 Mar, 2011 Chopped
C 06 Mar, 2011 Chopped
D 06 Mar, 2011 Chopped
E 06 Mar, 2011 Rejected
F 06 Mar, 2011 Rejected
G 06 Mar, 2011 Rejected
H 06 Mar, 2011 Rejected

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
3lzbA01 10 Mar, 2011 3.30.200.20 Assigned
3lzbA02 10 Mar, 2011 1.10.510.10 Assigned
3lzbB01 10 Mar, 2011 3.30.200.20 Assigned
3lzbB02 10 Mar, 2011 1.10.510.10 Assigned
3lzbC01 10 Mar, 2011 3.30.200.20 Assigned
3lzbC02 10 Mar, 2011 1.10.510.10 Assigned
3lzbD01 09 Mar, 2011 3.30.200.20 Assigned
3lzbD02 09 Mar, 2011 1.10.510.10 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
P00533 EGFR_HUMAN Homo sapiens Epidermal growth factor receptor
P00533 EGFR_HUMAN Homo sapiens Epidermal growth factor receptor
P00533 EGFR_HUMAN Homo sapiens Epidermal growth factor receptor
P00533 EGFR_HUMAN Homo sapiens Epidermal growth factor receptor
P00533 EGFR_HUMAN Homo sapiens Epidermal growth factor receptor
P00533 EGFR_HUMAN Homo sapiens Epidermal growth factor receptor
P00533 EGFR_HUMAN Homo sapiens Epidermal growth factor receptor
P00533 EGFR_HUMAN Homo sapiens Epidermal growth factor receptor