PDB Information

PDB3L54
MethodX-RAY DIFFRACTION
Host Organismunidentified baculovirus
Gene SourceHomo sapiens
Primary Citation
Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
Knight, S.D., Adams, N.D., Burgess, J.L., Chaudhari, A.M., Darcy, M.G., Donatelli, C.A., Luengo, J.I., Newlander, K.A., Parrish, C.A., Ridgers, L.H., Sarpong, M.A., Schmidt, S.J., Van Aller, G.S., Carson, J.D., Diamond, M.A., Elkins, P.A., Gardiner, C.M., Garver, E., Gilbert, S.A., Gontarek, R.R., Jackson, J.R., Kershner, K.L., Luo, L., Raha, K., Sherk, C.S., Sung, C.M., Sutton, D., Tummino, P.J., Wegrzyn, R.J., Auger, K.R., Dhanak, D.
ACS Med Chem Lett
HeaderTransferase
Released2009-12-21
Resolution2.300
CATH Insert Date04 Jul, 2010

PDB Images (7)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 04 Jul, 2010 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
3l54A01 18 Jul, 2010 3.10.20.90 Assigned
3l54A02 18 Jul, 2010 2.60.40.150 Assigned
3l54A03 18 Jul, 2010 1.25.40.70 Assigned
3l54A04 18 Jul, 2010 3.30.1010.10 Assigned
3l54A05 18 Jul, 2010 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P48736 PK3CG_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
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