Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).
Illig, C.R., Manthey, C.L., Wall, M.J., Meegalla, S.K., Chen, J., Wilson, K.J., Ballentine, S.K., Desjarlais, R.L., Schubert, C., Crysler, C.S., Chen, Y., Molloy, C.J., Chaikin, M.A., Donatelli, R.R., Yurkow, E., Zhou, Z., Player, M.R., Tomczuk, B.E.
J.Med.Chem.
