Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Owen, D.R., Walker, J.K., Jon Jacobsen, E., Freskos, J.N., Hughes, R.O., Brown, D.L., Bell, A.S., Brown, D.G., Phillips, C., Mischke, B.V., Molyneaux, J.M., Fobian, Y.M., Heasley, S.E., Moon, J.B., Stallings, W.C., Joseph Rogier, D., Fox, D.N., Palmer, M.J., Ringer, T., Rodriquez-Lens, M., Cubbage, J.W., Blevis-Bal, R.M., Benson, A.G., Acker, B.A., Maddux, T.M., Tollefson, M.B., Bond, B.R., Macinnes, A., Yu, Y.
Bioorg.Med.Chem.Lett.