Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
Ruebsam, F., Murphy, D.E., Tran, C.V., Li, L.S., Zhao, J., Dragovich, P.S., McGuire, H.M., Xiang, A.X., Sun, Z., Ayida, B.K., Blazel, J.K., Kim, S.H., Zhou, Y., Han, Q., Kissinger, C.R., Webber, S.E., Showalter, R.E., Shah, A.M., Tsan, M., Patel, R.A., Thompson, P.A., Lebrun, L.A., Hou, H.J., Kamran, R., Sergeeva, M.V., Bartkowski, D.M., Nolan, T.G., Norris, D.A., Khandurina, J., Brooks, J., Okamoto, E., Kirkovsky, L.
Bioorg.Med.Chem.Lett.
