PDB Information

PDB3F8S
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
Ammirati, M.J., Andrews, K.M., Boyer, D.D., Brodeur, A.M., Danley, D.E., Doran, S.D., Hulin, B., Liu, S., McPherson, R.K., Orena, S.J., Parker, J.C., Polivkova, J., Qiu, X., Soglia, C.B., Treadway, J.L., VanVolkenburg, M.A., Wilder, D.C., Piotrowski, D.W.
Bioorg.Med.Chem.Lett.
HeaderHydrolase
Released2008-11-13
Resolution2.430
CATH Insert Date16 Aug, 2009

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 16 Aug, 2009 Chopped
B 16 Aug, 2009 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
3f8sA01 08 Oct, 2009 2.140.10.30 Assigned
3f8sA02 08 Oct, 2009 3.40.50.1820 Assigned
3f8sB01 08 Oct, 2009 2.140.10.30 Assigned
3f8sB02 08 Oct, 2009 3.40.50.1820 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4
CATH-Gene3D is a Global Biodata Core Resource Learn more...