Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
Hudkins, R.L., Diebold, J.L., Tao, M., Josef, K.A., Park, C.H., Angeles, T.S., Aimone, L.D., Husten, J., Ator, M.A., Meyer, S.L., Holskin, B.P., Durkin, J.T., Fedorov, A.A., Fedorov, E.V., Almo, S.C., Mathiasen, J.R., Bozyczko-Coyne, D., Saporito, M.S., Scott, R.W., Mallamo, J.P.
J.Med.Chem.