PDB Information

PDB2YBS
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
Chowdhury, R., Yeoh, K.K., Tian, Y.M., Hillringhaus, L., Bagg, E.A., Rose, N.R., Leung, I.K., Li, X.S., Woon, E.C., Yang, M., McDonough, M.A., King, O.N., Clifton, I.J., Klose, R.J., Claridge, T.D., Ratcliffe, P.J., Schofield, C.J., Kawamura, A.
EMBO Rep.
HeaderOxidoreductase/Peptide
Released2011-03-10
Resolution2.320
CATH Insert Date03 Apr, 2011

PDB Images (7)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 04 Apr, 2011 Chopped
B 04 Apr, 2011 Chopped
C 04 Apr, 2011 Rejected
D 04 Apr, 2011 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
2ybsA01 30 Aug, 2013 2.60.120.650 Assigned
2ybsB01 30 Aug, 2013 2.60.120.650 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q16695 H31T_HUMAN Homo sapiens Histone H3.1t
Q16695 H31T_HUMAN Homo sapiens Histone H3.1t
O75164 KDM4A_HUMAN Homo sapiens Lysine-specific demethylase 4A
O75164 KDM4A_HUMAN Homo sapiens Lysine-specific demethylase 4A