PDB 2ph6

PDB Information

PDB2PH6
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Lindsley, S.R., Moore, K.P., Rajapakse, H.A., Selnick, H.G., Young, M.B., Zhu, H., Munshi, S., Kuo, L., McGaughey, G.B., Colussi, D., Crouthamel, M.C., Lai, M.T., Pietrak, B., Price, E.A., Sankaranarayanan, S., Simon, A.J., Seabrook, G.R., Hazuda, D.J., Pudvah, N.T., Hochman, J.H., Graham, S.L., Vacca, J.P., Nantermet, P.G.
Bioorg.Med.Chem.Lett.
HeaderHydrolase
Released2007-04-10
Resolution2.000
CATH Insert Date07 Jun, 2007

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 07 Jun, 2007 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
2ph6A01 18 Jul, 2007 2.40.70.10 Assigned
2ph6A02 18 Jul, 2007 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
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