PDB Information

PDB2GFS
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]-methanone (RO3201195), and Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase
Goldstein, D.M., Alfredson, T.A., Bertrand, J., Browner, M.F., Clifford, K., Dalrymple, S., Dunn, J., Freire-Moare, J., Harris, S.F., Labadie, S.S., La Fargue, J., Lapierre, J.M., Larrabee, S., Li, F., Papp, E., McWeeney, D., Ramesha, C., Roberts, R., Rotstein, D., San Pablo, B., Sjogren, E., So, O.Y., Talamas, F.X., Tao, W., Trejo, A., Villasenor, A., Welch, M., Welch, T., Weller, P., Whiteley, P.E., Young, K., Zipfel, S.
J.Med.Chem.
HeaderSignaling Protein, Transferase
Released2006-03-23
Resolution1.750
CATH Insert Date14 Jul, 2006

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 14 Jul, 2006 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
2gfsA01 16 Jul, 2007 3.30.200.20 Assigned
2gfsA02 16 Jul, 2007 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q16539 MK14_HUMAN Homo sapiens Mitogen-activated protein kinase 14
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