Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.
Burgey, C.S., Robinson, K.A., Lyle, T.A., Nantermet, P.G., Selnick, H.G., Isaacs, R.C., Lewis, S.D., Lucas, B.J., Krueger, J.A., Singh, R., Miller-Stein, C., White, R.B., Wong, B., Lyle, E.A., Stranieri, M.T., Cook, J.J., McMasters, D.R., Pellicore, J.M., Pal, S., Wallace, A.A., Clayton, F.C., Bohn, D., Welsh, D.C., Lynch, J.J., Yan, Y., Chen, Z., Kuo, L., Gardell, S.J., Shafer, J.A., Vacca, J.P.
Bioorg.Med.Chem.Lett.
