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CATH Superfamily 3.90.640.10

ATPase, substrate binding domain, subdomain 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Actin; Chain A, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ATPase, substrate binding domain, subdomain 4

This superfamily comprises structural domains found in several ATPases, including actin PFAM:PF00022, INTERPRO:IPR004000, Hsp70 PFAM:PF00012, INTERPRO:IPR013126, BadF/BadG/BcrA/BcrD PFAM:PF01869, various kinases (acetokinase PFAM:PF00871, INTERPRO:IPR000890, hexokinase PFAM:PF00349, INTERPRO:IPR022672, glucokinase PFAM:PF02685, INTERPRO:IPR003836, glycerol kinase), DnaK INTERPRO:IPR012725, ROK PFAM:PF00480, INTERPRO:IPR000600, PilM PFAM:PF11104, INTERPRO:IPR005883, Fumble PFAM:PF03630. Members of this superfamily have two lobes, one with nucleotide binding activity, and a second one with substrate binding activity. The lobes can be structurally divided into 4 subdomains - 1A, 1B, 2A, 2B (or 1, 2, 3, 4). The ATP binding site in these ATPases is well conserved, and is located at the junction of the two lobes, in a deep cleft. This superfamily entry represents subdomain 4 from the substrate binding domain (SBD).

SSF53067,PMID:23123194,DOI:10.1038/346623a0,PMID:24743229,PMID:20072699,PMID:16551075

GO Diversity

Unique GO annotations
860 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
17311 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 631
Domain clusters (>95% seq id): 41
Domain clusters (>35% seq id): 12
Unique PDBs: 354
Alignments
Structural Clusters (5A): 4
Structural Clusters (9A): 3
FunFam Clusters: 294
Function
Unique EC: 2
Unique GO: 860
Taxonomy
Unique Species: 17311