View in Gene3D

CATH Superfamily 3.10.260.40

BCL-6 corepressor, PCGF1 binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
BCL-6 corepressor, PCGF1 binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: BCL-6 corepressor, PCGF1 binding domain

Structural domains comprising this superfamily share the structure of the C-terminus of the BCL-6 corepressor (BCOR), involved in PCFG1 (polycomb-group RING finger homologue 1) binding. This domain is very selective in binding and, as a consequence, it has been named PCGF Ub-like fold discriminator (PUFD) which binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of PCGF1.

PCFGs mediate epigenetic modification of histones through the formation of repressive complexes and which highlights the importance of BCOR in development and health PMID:23523425

GO Diversity

Unique GO annotations
27 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
200 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 3
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 27
Taxonomy
Unique Species: 200