The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Spike glycoprotein, N-terminal domain
".
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"The spike protein on coronavirus envelopes recognises receptors through the activities of a receptor-binding subunit S1 before it fuses viral and host membranes through the activities of a membrane-fusion subunit S2. S1 contains two independent domains, an N-terminal domain (NTD) and a C domain, both of which can function as viral receptor-binding domains PMID:23091051. The NTD is a 13-stranded beta-sandwich with two antiparallel beta-sheets stacked against each other through hydrophobic interactions and has an overall galectin fold.
INTERPRO:IPR032500, PFAM:PF16451,DOI:10.1073/pnas.1104306108,DOI:10.1074/jbc.M112.418210
| Structures | |
|---|---|
| Domains: | 5 |
| Domain clusters (>95% seq id): | 3 |
| Domain clusters (>35% seq id): | 1 |
| Unique PDBs: | 3 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 2 |
| Function | |
| Unique EC: | |
| Unique GO: | 10 |
| Taxonomy | |
| Unique Species: | 114 |