The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"RuvB-like helicase, domain II
".
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"RuvBL1 is a ubiquitously expressed protein that plays important roles in chromatin remodeling, transcription, DNA repair, and apoptosis. The significant evolutionary conservation of RuvBL1 from yeast to man strongly suggests that it mediates important cellular functions. RuvBL1 belongs to a large family of ATPases known as AAA+ proteins (ATPases associated with diverse cellular activities) which generally form hexamers. RuvBL1 is the eukaryotic homologue of the bacterial DNA-dependent ATPase and helicase RuvB.
This entry represents the second domain of RuvBL1 which is involved in DNA/RNA binding PMID:17060327.
| Structures | |
|---|---|
| Domains: | 3 |
| Domain clusters (>95% seq id): | 2 |
| Domain clusters (>35% seq id): | 2 |
| Unique PDBs: | 2 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 9 |
| Function | |
| Unique EC: | 1 |
| Unique GO: | 94 |
| Taxonomy | |
| Unique Species: | 1625 |