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CATH Superfamily 1.20.1250.60

Interferon lambda

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Interferon lambda
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Interferon lambda

Structural domains comprising this superfamily share the structure of interferon lambda (IFN)-lambda proteins, which belong to the new type III IFN group. In contrast to type I or type II, the response to type III IFN is cell-type specific and only epithelial-like cells and some immune cells respond to IFN-lambda PMID:22190970. Four distinct proteins designated IFN-lambda1 (interleukin-29, IL-29), IFN-lambda2 (IL-28A), IFN_lambda3 (IL-28B) and IFNL4 have been identified in humans PMID:20712453,PMID:12469119,PMID:23291588. IFN-lambda proteins activate IFN-stimulated gene factor 3 (ISGF3), and are able to induce antiviral protection and MHC class I antigen expression PMID:22190970.

GO Diversity

Unique GO annotations
28 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
87 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 5
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 7
Function
Unique EC:
Unique GO: 28
Taxonomy
Unique Species: 87