# STOCKHOLM 1.0
#=GF ID 3.40.50.280/FF/000006
#=GF DE Methionine synthase (B12-dependent)
#=GF AC 3.40.50.280/FF/000006
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 93.652
#=GS Q8ABD0/744-895      AC Q8ABD0
#=GS Q8ABD0/744-895      OS Bacteroides thetaiotaomicron VPI-5482
#=GS Q8ABD0/744-895      DE Methionine synthase
#=GS Q8ABD0/744-895      DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides thetaiotaomicron; 
#=GS Q9WYA5/649-768      AC Q9WYA5
#=GS Q9WYA5/649-768      OS Thermotoga maritima MSB8
#=GS Q9WYA5/649-768      DE 5-methyltetrahydrofolate S-homocysteine methyltransferase
#=GS Q9WYA5/649-768      DR ORG; Bacteria; Thermotogae; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga; Thermotoga maritima; 
#=GS R4NY42/649-768      AC R4NY42
#=GS R4NY42/649-768      OS Thermotoga maritima MSB8
#=GS R4NY42/649-768      DE 5-methyltetrahydrofolate--homocysteine methyltransferase
#=GS R4NY42/649-768      DR ORG; Bacteria; Thermotogae; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga; Thermotoga maritima; 
#=GS Q748T0/681-803      AC Q748T0
#=GS Q748T0/681-803      OS Geobacter sulfurreducens PCA
#=GS Q748T0/681-803      DE 5-methyltetrahydrofolate--homocysteine S-methyltransferase, cobalamin-dependent
#=GS Q748T0/681-803      DR ORG; Bacteria; Proteobacteria; delta/epsilon subdivisions; Deltaproteobacteria; Desulfuromonadales; Geobacteraceae; Geobacter; Geobacter sulfurreducens; 
#=GS A5I293/669-790      AC A5I293
#=GS A5I293/669-790      OS Clostridium botulinum A str. Hall
#=GS A5I293/669-790      DE Putative methionine synthase
#=GS A5I293/669-790      DR ORG; Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium botulinum; 
#=GS Q8PAH2/413-565      AC Q8PAH2
#=GS Q8PAH2/413-565      OS Xanthomonas campestris pv. campestris str. ATCC 33913
#=GS Q8PAH2/413-565      DE Methionine synthase
#=GS Q8PAH2/413-565      DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Xanthomonas; Xanthomonas campestris; 
#=GS Q57195/134-286      AC Q57195
#=GS Q57195/134-286      OS Haemophilus influenzae Rd KW20
#=GS Q57195/134-286      DE Uncharacterized protein HI_1042
#=GS Q57195/134-286      DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus; Haemophilus influenzae; 
#=GS W4Y6E4/1053-1204    AC W4Y6E4
#=GS W4Y6E4/1053-1204    OS Strongylocentrotus purpuratus
#=GS W4Y6E4/1053-1204    DE Uncharacterized protein
#=GS W4Y6E4/1053-1204    DR ORG; Eukaryota; Metazoa; Echinodermata; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; Strongylocentrotus; Strongylocentrotus purpuratus; 
#=GS Q8AAX2/471-601      AC Q8AAX2
#=GS Q8AAX2/471-601      OS Bacteroides thetaiotaomicron VPI-5482
#=GS Q8AAX2/471-601      DE Trimethylamine corrinoid protein 2 (TCP 2)
#=GS Q8AAX2/471-601      DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides thetaiotaomicron; 
#=GS Q8TSD9/87-225       AC Q8TSD9
#=GS Q8TSD9/87-225       OS Methanosarcina acetivorans C2A
#=GS Q8TSD9/87-225       DE Uncharacterized protein
#=GS Q8TSD9/87-225       DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina acetivorans; 
#=GS Q8THX4/82-218       AC Q8THX4
#=GS Q8THX4/82-218       OS Methanosarcina acetivorans C2A
#=GS Q8THX4/82-218       DE Uncharacterized protein
#=GS Q8THX4/82-218       DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina acetivorans; 
#=GS Q8THF9/95-227       AC Q8THF9
#=GS Q8THF9/95-227       OS Methanosarcina acetivorans C2A
#=GS Q8THF9/95-227       DE Uncharacterized protein
#=GS Q8THF9/95-227       DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina acetivorans; 
#=GS C3YH00/817-969      AC C3YH00
#=GS C3YH00/817-969      OS Branchiostoma floridae
#=GS C3YH00/817-969      DE Methionine synthase
#=GS C3YH00/817-969      DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma floridae; 
#=GS A0A0R0ATJ1/412-564  AC A0A0R0ATJ1
#=GS A0A0R0ATJ1/412-564  OS Stenotrophomonas panacihumi
#=GS A0A0R0ATJ1/412-564  DE Methionine synthase
#=GS A0A0R0ATJ1/412-564  DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Stenotrophomonas; Stenotrophomonas panacihumi; 
#=GS D6D3U0/744-895      AC D6D3U0
#=GS D6D3U0/744-895      OS Bacteroides xylanisolvens XB1A
#=GS D6D3U0/744-895      DE Methionine synthase
#=GS D6D3U0/744-895      DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides xylanisolvens; 
#=GS A0A174JI92/744-895  AC A0A174JI92
#=GS A0A174JI92/744-895  OS Bacteroides caccae
#=GS A0A174JI92/744-895  DE Methionine synthase
#=GS A0A174JI92/744-895  DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides caccae; 
#=GS K5CQB5/744-895      AC K5CQB5
#=GS K5CQB5/744-895      OS Bacteroides finegoldii CL09T03C10
#=GS K5CQB5/744-895      DE Methionine synthase
#=GS K5CQB5/744-895      DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides finegoldii; 
#=GS A0A1C7GZH0/744-895  AC A0A1C7GZH0
#=GS A0A1C7GZH0/744-895  OS Bacteroides caecimuris
#=GS A0A1C7GZH0/744-895  DE Methionine synthase
#=GS A0A1C7GZH0/744-895  DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides caecimuris; 
#=GS B9KC48/649-768      AC B9KC48
#=GS B9KC48/649-768      OS Thermotoga neapolitana DSM 4359
#=GS B9KC48/649-768      DE 5-methyltetrahydrofolate S-homocysteine methyltransferase
#=GS B9KC48/649-768      DR ORG; Bacteria; Thermotogae; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga; Thermotoga neapolitana; 
#=GS A0A0B5KXW2/649-768  AC A0A0B5KXW2
#=GS A0A0B5KXW2/649-768  OS Thermotoga sp. RQ7
#=GS A0A0B5KXW2/649-768  DE 5-methyltetrahydrofolate--homocysteine methyltransferase
#=GS A0A0B5KXW2/649-768  DR ORG; Bacteria; Thermotogae; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga; Thermotoga sp. RQ7; 
#=GS A5IKF3/649-768      AC A5IKF3
#=GS A5IKF3/649-768      OS Thermotoga petrophila RKU-1
#=GS A5IKF3/649-768      DE Methionine synthase (B12-dependent)
#=GS A5IKF3/649-768      DR ORG; Bacteria; Thermotogae; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga; Thermotoga petrophila; 
#=GS A0A2N5RKX1/649-768  AC A0A2N5RKX1
#=GS A0A2N5RKX1/649-768  OS Thermotoga sp. KOL6
#=GS A0A2N5RKX1/649-768  DE 5-methyltetrahydrofolate--homocysteine methyltransferase
#=GS A0A2N5RKX1/649-768  DR ORG; Bacteria; Thermotogae; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga; Thermotoga sp. KOL6; 
#=GS A0A3E5GFW9/471-602  AC A0A3E5GFW9
#=GS A0A3E5GFW9/471-602  OS Bacteroides faecis
#=GS A0A3E5GFW9/471-602  DE Cobalamin-binding protein
#=GS A0A3E5GFW9/471-602  DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides faecis; 
#=GS A0A0E3NTF0/95-227   AC A0A0E3NTF0
#=GS A0A0E3NTF0/95-227   OS Methanosarcina sp. MTP4
#=GS A0A0E3NTF0/95-227   DE Dimethylsulfide methyltransferase corrinoid protein
#=GS A0A0E3NTF0/95-227   DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina sp. MTP4; 
#=GS A0A0P0F710/744-895  AC A0A0P0F710
#=GS A0A0P0F710/744-895  OS Bacteroides thetaiotaomicron
#=GS A0A0P0F710/744-895  DE Methionine synthase
#=GS A0A0P0F710/744-895  DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides thetaiotaomicron; 
#=GS A0A0H2X8N6/413-565  AC A0A0H2X8N6
#=GS A0A0H2X8N6/413-565  OS Xanthomonas campestris pv. campestris str. 8004
#=GS A0A0H2X8N6/413-565  DE Methionine synthase
#=GS A0A0H2X8N6/413-565  DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Xanthomonas; Xanthomonas campestris; 
#=GS A0A0P0F1L0/471-601  AC A0A0P0F1L0
#=GS A0A0P0F1L0/471-601  OS Bacteroides thetaiotaomicron
#=GS A0A0P0F1L0/471-601  DE Methanosarcina family methyltransferase cognate corrinoid protein
#=GS A0A0P0F1L0/471-601  DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides thetaiotaomicron; 
#=GS A0A174R416/471-602  AC A0A174R416
#=GS A0A174R416/471-602  OS Bacteroides thetaiotaomicron
#=GS A0A174R416/471-602  DE Trimethylamine corrinoid protein 2
#=GS A0A174R416/471-602  DR ORG; Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides thetaiotaomicron; 
#=GF SQ 28
Q8ABD0/744-895              -------SSAGKVLLATVKGDVHDIGKNIVAVVMACNGYDIVDLGVMVPAETIVQRAIEEKVDMIGLSGLITPSLEEMTHVAAELEKAGLD--IPLLIGGATTSKMHTALKIAPVYHAPVV-HLKDASQNASVASRLLNSQMKAELINELDAEYQALREKSG
Q9WYA5/649-768              ----------ETFVIATVKGDVHDIGKNIVASVIRSSGYRVVDLGKDVDTSEIVEAVEKERPVALGLSAMMTTTVGRIKEVVEKLKEKNLK--IPVIVGGASLNEKLAKELGADYYA-------KNASEAVKILKSL-GR----------------------
R4NY42/649-768              ----------ETFVIATVKGDVHDIGKNIVASVIRSSGYRVVDLGKDVDTSEIVEAVEKERPVALGLSAMMTTTVGRIKEVVEKLKEKNLK--IPVIVGGASLNEKLAKELGADYYA-------KNASEAVKILKSL-GR----------------------
Q748T0/681-803              --------SKGTILMATVEGDIHDIGKNIVCTLLENHGFRVIDLGKNVPADRIVAEAERNGADAVGLSALMTTTMTEMENVLARLRAAGIR--TFTMVGGAVVTQEYADRIGADLYA-------RDAMDAVARIKALLGV----------------------
A5I293/669-790              --------NKGKILMATVKGDIHDIGKNIVKVILENYGFDIIDLGKDVEAEKIVEEVKKNNIKLVGLSALMTTTVNSMRDTIKILKESGMD--CKVFVGGAVLNEEYAKMINADYYA-------KDAKEAVDIAKGFFG-----------------------
Q8PAH2/413-565              ------GKSNGKIIMATVKGDVHDIGKNIVGVVLACNNFDVVDLGVMVSAQVILDRAREENADLIGLSGLITPSLEEMSHVAREMQRQGFE--IPLLIGGATTSRAHTALKIDPHYTAPTV-WVKDASRAVGVAQSLISRDLRQAFVAANEADYAEIRARHR
Q57195/134-286              -------SSNGKVVIATVKGDVHDIGKNIVSVVMQCNNFEVIDLGVMVPADKIIQTAINQKTDIIALSGLITPSLDEMEYFLGEMTRLGLN--LPVMIGGATTSKEHTAIKLYPKYKQHCVFYTSNASRAVTVCATLMNPEGRAALWEQFKKDYEKIQQSFA
W4Y6E4/1053-1204            -------FNNGTIVLATVKGDVHDIGKNIVGVVLGCNNYRVIDLGVMTPCEKILQTAIQEKADIVGLSGLITPSLDEMIHVAKEMERLGFS--LPLLIGGATTSKTHTAVKIAPCYSSPTI-HVLDASKSVVVCSSLIDEDRYDDYVEEVKEEYEEVREDHY
Q8AAX2/471-601              ---GNASATIGKIVIGTVKGDLHDIGKNLVASMLEGCGFEVINIGIDVTCDKFVEAVKENKADILCMSALLTTTMTYMQDVIRALEEAGIRDQVKVMIGGAPVSQGFADEIGADGYS-------DNANTAVAVAKVLMGKR---------------------
Q8TSD9/87-225               EMIKEGEAMQAVGVIGTIEGDVHDIGKNLVKTMLSAGGFEMIDLGADVPIEKFVETAKERKADIISMSALMTTTMTNMEKVIEILQEEGIRDSMKVMIGGAPVSEEYASGIGADSTH-------PDAMHASAWASEAVKELEPKAA----------------
Q8THX4/82-218               YMKVDGTAAPKNVIIGTVEGDVHDIGKNLVKTMMTAAGFNMIDLGCDVPLDKFAETAKEKKAAAISMSTLMTTTMGGMETVIEQLQEEGIRDSLIVMVGGAPISQTFADSVGADGTA-------LDASAAVETLTSLVSELPSD------------------
Q8THF9/95-227               -LKSDSTNKPSKIIIGTVEGDVHDIGKNLVKTMMTAAGFDMIDLGSDVPLSSFVSSARDQKADAISMSTLMTTTMPGMEKVIEQLKEEGLRDSLLVMVGGAPINADYAAKIGADATR-------DDASAATEWLKGAIVEL---------------------
C3YH00/817-969              ------AKYAGTIVLATVKGDVHDIGKNIVGVVLGCNNYRVIDLGVMTPCEKILKTAVEENADIVGLSGLITPSLDEMIFVAKEMQRVGLK--LPLLIGGATTSKTHTAVKIAPRYKEPVI-HVLDASKSVVVCSALMDEDQKEDLTEDVAEEYEEIREEHY
A0A0R0ATJ1/412-564          ------SRSNGKIIMATVKGDVHDIGKNIVGVVLACNNFEVVDLGVMVPAQTILDRAREENADLIGLSGLITPSLEEMSHVARELERQKFE--IPLLIGGATTSRAHTALKIDPHYHAPTI-WVKDASRAVGVAQSLISRELRGAFVAANDTDYAEIRQRHR
D6D3U0/744-895              -------AAAGKVLLATVKGDVHDIGKNIVAVVMACNGYDIVDLGVMVPAETIVQRAIEEKVDMIGLSGLITPSLEEMAHVALELEKAGLD--IPLLIGGATTSKMHTALKIAPVYHAPVV-HLKDASQNASVASKLLNPQLKAELVNELNSEYEVLREKSG
A0A174JI92/744-895          -------TSAGKVLLATVKGDVHDIGKNIVAVVMACNGYEIVDLGVMVPAETIVQRAIEEKVDMIGLSGLITPSLEEMAHVAIELEKAGLD--IPLLIGGATTSKMHTALKIAPVYHAPVV-HLKDASQNASVASRLLNPQLKAELVNELEAEYEALREKSG
K5CQB5/744-895              -------TSAGKILLATVKGDVHDIGKNIVAVVMACNGYDIVDLGVMVPAETIVQRAIEEKVDMIGLSGLITPSLEEMAHVAGELEKAGLD--IPLLIGGATTSKMHTALKIAPVYHAPVV-HLKDASQNAGVAARLLNPQAKVELVNELVTEYEALREKSG
A0A1C7GZH0/744-895          -------AAAGKVLLATVKGDVHDIGKNIVAVVMACNGYDIVDLGVMVPAETIVQRAIEEKVDMIGLSGLITPSLEEMAHVALELEKAGLD--IPLLIGGATTSKMHTALKIAPVYHAPVV-HLKDASQNASVASKLLNPQLKAELVNELNSEYEALREKSG
B9KC48/649-768              ----------ETFVIATVKGDVHDIGKNIVASVIRSSGYRVVDLGKDVDTERIVEAVEKEKPVALGLSAMMTTTVGRIKEVVESLKKKGLK--VPVIAGGASLNEKLAKELGADYYA-------KNASEAVKILKSL-GR----------------------
A0A0B5KXW2/649-768          ----------ETFVIATVKGDVHDIGKNIVASVIRSSGYRVVDLGKDVDTERIVEAVEKEKPVALGLSAMMTTTVGRIKEVVESLKKKGLK--VPVIAGGASLNEKLAKELGADYYA-------KNASEAVKILKSL-GR----------------------
A5IKF3/649-768              ----------ETFVIATVKGDVHDIGKNIVASVIRSSGYRVVDLGKDVETSKILETVEKERPVALGLSAMMTTTVGRIKEVVEKLKEKNLK--IPVIVGGASLNEKLAKELGADYYA-------RNASEAVKILKSL-GR----------------------
A0A2N5RKX1/649-768          ----------ATFVIATVKGDVHDIGKNIVASVIRSSGYRVIDLGKDVETEKIVETVEKEKPVALGLSAMMTTTVGKIKEVVEKLKEKGLK--VPVIVGGASLNEKLAKELGADYYA-------KNASEAVKILKSI-GR----------------------
A0A3E5GFW9/471-602          ---GNASTTIGKIVIGTVKGDLHDIGKNLVASMLEGCGFEVINIGIDVTCDKFVEAVKENNADILCMSALLTTTMTYMKDVIQALEDAGIRSQVKVMIGGAPVSQGFADEIGADGYS-------DNANTAVAVAKELMGNKK--------------------
A0A0E3NTF0/95-227           -LKTDSTNKPSKIIIGTVEGDVHDIGKNLVKTMMTAAGFDMVDLGSDVTLSSFVSSARDQQADAISMSTLMTTTMPGMEKVIEQLKEEGLRDSLLVMVGGAPINADYAEKIGADATK-------NDASQATEWLTGAIAEL---------------------
A0A0P0F710/744-895          -------SSAGKVLLATVKGDVHDIGKNIVAVVMACNGYDIVDLGVMVPAETIVQRAIEEKVDMIGLSGLITPSLEEMTHVAAELEKAGLD--IPLLIGGATTSKMHTALKIAPVYHAPVV-HLKDASQNASVASRLLNSQMKAELINELDAEYQALREKSG
A0A0H2X8N6/413-565          ------GKSNGKIIMATVKGDVHDIGKNIVGVVLACNNFDVVDLGVMVSAQVILDRAREENADLIGLSGLITPSLEEMSHVAREMQRQGFE--IPLLIGGATTSRAHTALKIDPHYTAPTV-WVKDASRAVGVAQSLISRDLRQAFVAANEADYAEIRARHR
A0A0P0F1L0/471-601          ---GNASATIGKIVIGTVKGDLHDIGKNLVASMLEGCGFEVINIGIDVTCDKFVEAVKENKADILCMSALLTTTMTYMQDVIRALEEAGIRDQVKVMIGGAPVSQGFADEIGADGYS-------DNANTAVAVAKVLMGKR---------------------
A0A174R416/471-602          ---GNASTTIGKIVIGTVKGDLHDIGKNLVASMLEGCGFEVINIGIDVTCDKFVEAVKENNADILCMSALLTTTMTYMKDVIQALEDAGIRSQVKVMIGGAPVSQGFADEIGADGYS-------DNANTAVAVAKELMGNKK--------------------
#=GC scorecons              000000012255566698799799999969546634467567779448445466546355555465795769665447348534755375400546569995464356434475364010100046964663544363431110110000001100110000
#=GC scorecons_70           _______________***************__*____**_*****__*____**__*_________**_*_*_____*__*___*___*______*_****______*____*__*_________***_*______*_________________________
#=GC scorecons_80           ________________************_*________*___***__*___________________*_*_*_____*__*___*___*_________***_________________________*___________________________________
#=GC scorecons_90           ________________**_**_******_*______________*__*___________________*___*________*_________________***_________________________*___________________________________
//