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CATH Superfamily 3.40.50.12100

Stimulator of interferon genes protein

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Stimulator of interferon genes protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Stimulator of interferon genes protein

According to the literature, members of the structural domains which comprise this superfamily correspond to the structure of the transmembrane adapter protein STING. An alternative name for this protein is transmembrane protein 173.

This protein is an innate immune sensor of cyclic dinucleotides that regulates the induction of type I interferons PMID:22728658

GO Diversity

Unique GO annotations
49 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
270 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 79
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 2
Unique PDBs: 44
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 8
Function
Unique EC:
Unique GO: 49
Taxonomy
Unique Species: 270
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