# STOCKHOLM 1.0
#=GF ID 1.20.120.1710/FF/000001
#=GF DE NAD-dependent histone deacetylase SIR2
#=GF AC 1.20.120.1710/FF/000001
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 75.118
#=GS 4iaoB01/31-166     AC P06700
#=GS 4iaoB01/31-166     OS Saccharomyces cerevisiae S288C
#=GS 4iaoB01/31-166     DE NAD-dependent histone deacetylase SIR2
#=GS 4iaoB01/31-166     DR CATH; 4iao; B:101-236; 
#=GS 4iaoB01/31-166     DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS 4iaoB01/31-166     DR GO; GO:0000183; GO:0000784; GO:0001300; GO:0001302; GO:0005515; GO:0005677; GO:0005720; GO:0005724; GO:0005730; GO:0006303; GO:0006325; GO:0006333; GO:0006348; GO:0007062; GO:0008156; GO:0017136; GO:0030466; GO:0030869; GO:0032041; GO:0034398; GO:0045910; GO:0046969; GO:0046970; GO:0097695; GO:1904524; 
#=GS P53685/42-182      AC P53685
#=GS P53685/42-182      OS Saccharomyces cerevisiae S288C
#=GS P53685/42-182      DE NAD-dependent protein deacetylase HST1
#=GS P53685/42-182      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS P53685/42-182      DR GO; GO:0016575; GO:0017136; GO:0030466; GO:0034967; GO:0045129; GO:0045950; GO:0070623; 
#=GS Q6FWI7/51-184      AC Q6FWI7
#=GS Q6FWI7/51-184      OS [Candida] glabrata CBS 138
#=GS Q6FWI7/51-184      DE NAD-dependent histone deacetylase SIR2
#=GS Q6FWI7/51-184      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces; [Candida] glabrata; 
#=GS Q6FWI7/51-184      DR GO; GO:0004407; 
#=GS 4iaoA01/29-166     AC P06700
#=GS 4iaoA01/29-166     OS Saccharomyces cerevisiae S288C
#=GS 4iaoA01/29-166     DE NAD-dependent histone deacetylase SIR2
#=GS 4iaoA01/29-166     DR CATH; 4iao; A:99-236; 
#=GS 4iaoA01/29-166     DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS 4iaoA01/29-166     DR GO; GO:0000183; GO:0000784; GO:0001300; GO:0001302; GO:0005515; GO:0005677; GO:0005720; GO:0005724; GO:0005730; GO:0006303; GO:0006325; GO:0006333; GO:0006348; GO:0007062; GO:0008156; GO:0017136; GO:0030466; GO:0030869; GO:0032041; GO:0034398; GO:0045910; GO:0046969; GO:0046970; GO:0097695; GO:1904524; 
#=GS P06700/99-236      AC P06700
#=GS P06700/99-236      OS Saccharomyces cerevisiae S288C
#=GS P06700/99-236      DE NAD-dependent histone deacetylase SIR2
#=GS P06700/99-236      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS P06700/99-236      DR GO; GO:0000183; GO:0000784; GO:0001300; GO:0001302; GO:0005515; GO:0005677; GO:0005720; GO:0005724; GO:0005730; GO:0006303; GO:0006325; GO:0006333; GO:0006348; GO:0007062; GO:0008156; GO:0017136; GO:0030466; GO:0030869; GO:0032041; GO:0034398; GO:0045910; GO:0046969; GO:0046970; GO:0097695; GO:1904524; 
#=GS Q757M7/71-222      AC Q757M7
#=GS Q757M7/71-222      OS Eremothecium gossypii ATCC 10895
#=GS Q757M7/71-222      DE NAD-dependent histone deacetylase SIR2
#=GS Q757M7/71-222      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium; Eremothecium gossypii; 
#=GS R9XDV4/71-222      AC R9XDV4
#=GS R9XDV4/71-222      OS Saccharomycetaceae sp. 'Ashbya aceri'
#=GS R9XDV4/71-222      DE AaceriAEL013Cp
#=GS R9XDV4/71-222      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomycetaceae sp. 'Ashbya aceri'; 
#=GS H0GN55/14-154      AC H0GN55
#=GS H0GN55/14-154      OS Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7
#=GS H0GN55/14-154      DE Hst1p
#=GS H0GN55/14-154      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae x Saccharomyces kudriavzevii; 
#=GS A0A0L8VI24/12-152  AC A0A0L8VI24
#=GS A0A0L8VI24/12-152  OS Saccharomyces sp. 'boulardii'
#=GS A0A0L8VI24/12-152  DE HST1p NAD(+)-dependent histone deacetylase
#=GS A0A0L8VI24/12-152  DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces sp. 'boulardii'; 
#=GS N1P426/42-182      AC N1P426
#=GS N1P426/42-182      OS Saccharomyces cerevisiae CEN.PK113-7D
#=GS N1P426/42-182      DE Hst1p
#=GS N1P426/42-182      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS A6ZNE2/42-182      AC A6ZNE2
#=GS A6ZNE2/42-182      OS Saccharomyces cerevisiae YJM789
#=GS A6ZNE2/42-182      DE Conserved protein
#=GS A6ZNE2/42-182      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS G2WMG6/42-182      AC G2WMG6
#=GS G2WMG6/42-182      OS Saccharomyces cerevisiae Kyokai no. 7
#=GS G2WMG6/42-182      DE K7_Hst1p
#=GS G2WMG6/42-182      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS C7GK35/42-182      AC C7GK35
#=GS C7GK35/42-182      OS Saccharomyces cerevisiae JAY291
#=GS C7GK35/42-182      DE Hst1p
#=GS C7GK35/42-182      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS C8ZHP7/42-182      AC C8ZHP7
#=GS C8ZHP7/42-182      OS Saccharomyces cerevisiae EC1118
#=GS C8ZHP7/42-182      DE Hst1p
#=GS C8ZHP7/42-182      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS B5VRI4/42-182      AC B5VRI4
#=GS B5VRI4/42-182      OS Saccharomyces cerevisiae AWRI1631
#=GS B5VRI4/42-182      DE YOL068Cp-like protein
#=GS B5VRI4/42-182      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS B3LIZ2/42-182      AC B3LIZ2
#=GS B3LIZ2/42-182      OS Saccharomyces cerevisiae RM11-1a
#=GS B3LIZ2/42-182      DE NAD-dependent histone deacetylase SIR2
#=GS B3LIZ2/42-182      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS A0A0L8VWP1/99-236  AC A0A0L8VWP1
#=GS A0A0L8VWP1/99-236  OS Saccharomyces sp. 'boulardii'
#=GS A0A0L8VWP1/99-236  DE SIR2p NAD+ dependent histone deacetylase of the Sirtuin family
#=GS A0A0L8VWP1/99-236  DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces sp. 'boulardii'; 
#=GS B3LGU0/99-236      AC B3LGU0
#=GS B3LGU0/99-236      OS Saccharomyces cerevisiae RM11-1a
#=GS B3LGU0/99-236      DE NAD-dependent histone deacetylase SIR2
#=GS B3LGU0/99-236      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS B5VFM5/99-236      AC B5VFM5
#=GS B5VFM5/99-236      OS Saccharomyces cerevisiae AWRI1631
#=GS B5VFM5/99-236      DE YDL042Cp-like protein
#=GS B5VFM5/99-236      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS N1P5V5/99-236      AC N1P5V5
#=GS N1P5V5/99-236      OS Saccharomyces cerevisiae CEN.PK113-7D
#=GS N1P5V5/99-236      DE Sir2p
#=GS N1P5V5/99-236      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS H0GDU1/99-236      AC H0GDU1
#=GS H0GDU1/99-236      OS Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7
#=GS H0GDU1/99-236      DE Sir2p
#=GS H0GDU1/99-236      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae x Saccharomyces kudriavzevii; 
#=GS C8Z4M8/99-236      AC C8Z4M8
#=GS C8Z4M8/99-236      OS Saccharomyces cerevisiae EC1118
#=GS C8Z4M8/99-236      DE Sir2p
#=GS C8Z4M8/99-236      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS A6ZXT3/99-236      AC A6ZXT3
#=GS A6ZXT3/99-236      OS Saccharomyces cerevisiae YJM789
#=GS A6ZXT3/99-236      DE Nuclear NAD-dependent deacetylase
#=GS A6ZXT3/99-236      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS G2WCB9/99-236      AC G2WCB9
#=GS G2WCB9/99-236      OS Saccharomyces cerevisiae Kyokai no. 7
#=GS G2WCB9/99-236      DE K7_Sir2p
#=GS G2WCB9/99-236      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS Q2UZW1/51-184      AC Q2UZW1
#=GS Q2UZW1/51-184      OS [Candida] glabrata
#=GS Q2UZW1/51-184      DE NAD-dependent histone deacetylase SIR2
#=GS Q2UZW1/51-184      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces; [Candida] glabrata; 
#=GF SQ 25
4iaoB01/31-166             --SNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGS----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
P53685/42-182              NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
Q6FWI7/51-184              PEKAALL-PKIPKKSPVSIGMNPENGKYVLPNYSKDESLNARKFLKYYGLRKFLDTYLPEELNSLYIYSLIKLLGFEIRDKELLSSLYRFFHP-----------VKSSDQFK---------LEYEDFTDPLEKKEAVKLIKDLQKAINRVLATRI
4iaoA01/29-166             SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGS----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
P06700/99-236              SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGS----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
Q757M7/71-222              -VAGEYV-PKKP-EQPIMLTKDSNSGKYVFPPISKEDSLNARYFLKYHGSAQFLDSYLPEDLNSLYVFHLIKLLGFQLKDRELLTAVQKAVQNDVTSGVSSVVGTNPMVERVSPPQLSASTPSGDGYDDPLEKKHAVRLIKDLQKAMNKVLSTRI
R9XDV4/71-222              -VTGEYV-PNKP-EQPIMLTKDANSGKYVFPPISKEDSLNARYFLKYHGSAQFLDSYLPEDLNSLYVFHLIKLLGFQLKDRELLTAVQKAVQNDITSGVSSIVGTNPMVERVSPPQLSASTPSSDGYDDPLEKKHAVRLIKDLQKAMNKVLSTRI
H0GN55/14-154              NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
A0A0L8VI24/12-152          NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
N1P426/42-182              NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
A6ZNE2/42-182              NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
G2WMG6/42-182              NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
C7GK35/42-182              NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
C8ZHP7/42-182              NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
B5VRI4/42-182              NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
B3LIZ2/42-182              NNATKKL-KTRL-TYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNIT------------SNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRL
A0A0L8VWP1/99-236          SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGS----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
B3LGU0/99-236              SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGS----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
B5VFM5/99-236              SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGS----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
N1P5V5/99-236              SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGS----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
H0GDU1/99-236              SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGG----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
C8Z4M8/99-236              SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGG----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
A6ZXT3/99-236              SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEVLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGS----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
G2WCB9/99-236              SMSNDVLKPETP-KGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVH------------INSQERVQDLGS----AISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRL
Q2UZW1/51-184              PEKAALL-PKIPKKSPVSIGKNPENGKYVLPNYSKDESLNARKFLKYYGLRKFLDTYLPEELNSLYIYSLIKLLGFEIRDKELLSSLYRFFHP-----------VKSSDQFK---------LEYEDFTDPLEKKEAVKLIKDLQKAINRVLATRI
#=GC scorecons             33554371544605395665864459574495569575699949995564559974799566996988569999996789659545666465000000000000475444444545112163535555999599669799999979898995997
#=GC scorecons_70          ______*________*_**_**___*_*__*__**_*_****_***__*___***_***_********_***********__*____**_*______________*______________________***_**_****************_***
#=GC scorecons_80          ______*________*____*____*_*__*___*____***_***______***_***___**_***__******_***__*______________________*______________________***_**__*_*************_***
#=GC scorecons_90          _______________*____*____*____*___*____***_***______**___**___**_***__******__**__*_____________________________________________***_**__*_******_*_****_**_
//