# STOCKHOLM 1.0 #=GF ID 3.90.70.80/FF/000021 #=GF DE Ubiquitin thioesterase OTU1 #=GF AC 3.90.70.80/FF/000021 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 73.120 #=GS 3c0rC00/1-177 AC P43558 #=GS 3c0rC00/1-177 OS Saccharomyces cerevisiae S288C #=GS 3c0rC00/1-177 DE Ubiquitin thioesterase OTU1 #=GS 3c0rC00/1-177 DR CATH; 3c0r; C:92-266; #=GS 3c0rC00/1-177 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS 3c0rC00/1-177 DR GO; GO:0004843; GO:0005634; GO:0005737; GO:0006355; GO:0016579; #=GS 3c0rC00/1-177 DR EC; 3.4.19.12; #=GS Q38A95/90-263 AC Q38A95 #=GS Q38A95/90-263 OS Trypanosoma brucei brucei TREU927 #=GS Q38A95/90-263 DE Uncharacterized protein #=GS Q38A95/90-263 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; #=GS Q38A95/90-263 DR GO; GO:0005737; GO:0031981; GO:0097014; #=GS 3c0rA00/1-177 AC P43558 #=GS 3c0rA00/1-177 OS Saccharomyces cerevisiae S288C #=GS 3c0rA00/1-177 DE Ubiquitin thioesterase OTU1 #=GS 3c0rA00/1-177 DR CATH; 3c0r; A:92-266; #=GS 3c0rA00/1-177 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS 3c0rA00/1-177 DR GO; GO:0004843; GO:0005634; GO:0005737; GO:0006355; GO:0016579; #=GS 3c0rA00/1-177 DR EC; 3.4.19.12; #=GS 3by4A00/1-174 AC P43558 #=GS 3by4A00/1-174 OS Saccharomyces cerevisiae S288C #=GS 3by4A00/1-174 DE Ubiquitin thioesterase OTU1 #=GS 3by4A00/1-174 DR CATH; 3by4; A:92-263; #=GS 3by4A00/1-174 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS 3by4A00/1-174 DR GO; GO:0004843; GO:0005634; GO:0005737; GO:0006355; GO:0016579; #=GS 3by4A00/1-174 DR EC; 3.4.19.12; #=GS P43558/90-263 AC P43558 #=GS P43558/90-263 OS Saccharomyces cerevisiae S288C #=GS P43558/90-263 DE Ubiquitin thioesterase OTU1 #=GS P43558/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS P43558/90-263 DR GO; GO:0004843; GO:0005634; GO:0005737; GO:0006355; GO:0016579; #=GS P43558/90-263 DR EC; 3.4.19.12; #=GS E9BUY5/211-381 AC E9BUY5 #=GS E9BUY5/211-381 OS Leishmania donovani BPK282A1 #=GS E9BUY5/211-381 DE Uncharacterized protein #=GS E9BUY5/211-381 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; #=GS A0A1G4IGJ9/90-263 AC A0A1G4IGJ9 #=GS A0A1G4IGJ9/90-263 OS Trypanosoma equiperdum #=GS A0A1G4IGJ9/90-263 DE OTU-like cysteine protease, putative #=GS A0A1G4IGJ9/90-263 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma equiperdum; #=GS Q4Q0F8/206-380 AC Q4Q0F8 #=GS Q4Q0F8/206-380 OS Leishmania major #=GS Q4Q0F8/206-380 DE Uncharacterized protein #=GS Q4Q0F8/206-380 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania major species complex; Leishmania major; #=GS E9AU37/90-264 AC E9AU37 #=GS E9AU37/90-264 OS Leishmania mexicana MHOM/GT/2001/U1103 #=GS E9AU37/90-264 DE Uncharacterized protein #=GS E9AU37/90-264 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania mexicana; #=GS A0A3L6KWA4/90-263 AC A0A3L6KWA4 #=GS A0A3L6KWA4/90-263 OS Trypanosoma brucei equiperdum #=GS A0A3L6KWA4/90-263 DE OTU-like cysteine protease #=GS A0A3L6KWA4/90-263 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei equiperdum; #=GS D0A3Y1/90-263 AC D0A3Y1 #=GS D0A3Y1/90-263 OS Trypanosoma brucei gambiense DAL972 #=GS D0A3Y1/90-263 DE Uncharacterized protein #=GS D0A3Y1/90-263 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei gambiense; #=GS A4IE15/211-381 AC A4IE15 #=GS A4IE15/211-381 OS Leishmania infantum #=GS A4IE15/211-381 DE Uncharacterized protein #=GS A4IE15/211-381 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; #=GS H0GFK1/90-263 AC H0GFK1 #=GS H0GFK1/90-263 OS Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7 #=GS H0GFK1/90-263 DE Otu1p #=GS H0GFK1/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae x Saccharomyces kudriavzevii; #=GS A0A0L8VR40/90-263 AC A0A0L8VR40 #=GS A0A0L8VR40/90-263 OS Saccharomyces sp. 'boulardii' #=GS A0A0L8VR40/90-263 DE OTU1p Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p #=GS A0A0L8VR40/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces sp. 'boulardii'; #=GS A0A0L8RJV8/129-303 AC A0A0L8RJV8 #=GS A0A0L8RJV8/129-303 OS Saccharomyces eubayanus #=GS A0A0L8RJV8/129-303 DE OTU1-like protein #=GS A0A0L8RJV8/129-303 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces eubayanus; #=GS N1P319/90-263 AC N1P319 #=GS N1P319/90-263 OS Saccharomyces cerevisiae CEN.PK113-7D #=GS N1P319/90-263 DE Otu1p #=GS N1P319/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS N1P319/90-263 DR EC; 3.4.19.12; #=GS B3LUG7/90-263 AC B3LUG7 #=GS B3LUG7/90-263 OS Saccharomyces cerevisiae RM11-1a #=GS B3LUG7/90-263 DE De-ubiquitylation enzyme family #=GS B3LUG7/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS C8Z7N8/90-263 AC C8Z7N8 #=GS C8Z7N8/90-263 OS Saccharomyces cerevisiae EC1118 #=GS C8Z7N8/90-263 DE Otu1p #=GS C8Z7N8/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS A7A1Z5/90-263 AC A7A1Z5 #=GS A7A1Z5/90-263 OS Saccharomyces cerevisiae YJM789 #=GS A7A1Z5/90-263 DE De-ubiquitylation enzyme of the OTU family #=GS A7A1Z5/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS B5VHY3/90-263 AC B5VHY3 #=GS B5VHY3/90-263 OS Saccharomyces cerevisiae AWRI1631 #=GS B5VHY3/90-263 DE YFL044Cp-like protein #=GS B5VHY3/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS G2WD97/90-263 AC G2WD97 #=GS G2WD97/90-263 OS Saccharomyces cerevisiae Kyokai no. 7 #=GS G2WD97/90-263 DE K7_Otu1p #=GS G2WD97/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS C7GY70/90-263 AC C7GY70 #=GS C7GY70/90-263 OS Saccharomyces cerevisiae JAY291 #=GS C7GY70/90-263 DE Otu1p #=GS C7GY70/90-263 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GF SQ 22 3c0rC00/1-177 XKRVLKSTEXSIGGSGENVLSVHPVLDDNSCLFHAIAYGIFKQDSVR--DLREXVSKEVLNNPVKFND-AILDKPNKDYAQWILKXESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTXNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSFNTH Q38A95/90-263 -RYV-----PPVDGKWHFVRRVCP--SDNSCLFHAAAYVLRNKSRVDGPSLRKECADIVQAYPNVFNEKTILDRPNREYVDFIRNPNAWGGAIELMVLSFLTQTEIVALDLTSSNVLHFGEDNNYTVRAYVVFNGQHYDAIAMN---PMFN-SPQESEDQVLFSSTDAEVLNRARRFVADEAKKLR--------- 3c0rA00/1-177 XKRVLKSTEXSIGGSGENVLSVHPVLDDNSCLFHAIAYGIFKQDSVR--DLREXVSKEVLNNPVKFND-AILDKPNKDYAQWILKXESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTXNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSFNTH 3by4A00/1-174 MKRVLKSTEMSIGGSGENVLSVHPVLDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- P43558/90-263 PKRVLKSTEMSIGGSGENVLSVHPVLDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- E9BUY5/211-381 ---------PPAPERAHLTRRRCP--ADNSCLFHACAYVLRDKSRTEGPQLRQECVQAVLDHPEMFNVNTLGMDP-LAYASWLSEKDTWGGAIELEILSFLYKTEIFALDLQSVTLQRFGTGMGYTVRAFLVYTGNHYDCIAMN---PVYN-PTSEREDQTLFSSRDENVLARAKRFVAEEGQKMKE-------- A0A1G4IGJ9/90-263 -RYV-----PPVDGKWHFVRRVCP--SDNSCLFHAAAYVLRNKSRVDGPSLRKECADIVQAYPNVFNEKTILDRPNREYVDFIRNPNAWGGAIELMVLSFLTQTEIVALDLTSSNVLHFGEDNNYTVRAYVVFNGQHYDAIAMN---PMFN-SPQESEDQVLFSSTDAEVLNRARRFVADEAKKLR--------- Q4Q0F8/206-380 ERYV-----PPAPERAHLTRRRCP--ADNSCLFHACAYVLRDKSRTEGPQLRQECVQAVLDHPEMFNVNTLGMDP-LAYASWLSQKDTWGGAIELEILSFLYKTEMFALDLQSVTVQRFGTGLGYTVRAFLVYTGNHYDCIAMN---PVYN-SASEREDQTLFSSRDENVLVRAKRFVAEEGQKMKE-------- E9AU37/90-264 ERYV-----PPAPERAHLTRRRCP--ADNSCLFHACAYVLRDKSRTEGPQLRQECVKAVLDHPEMFNENTLGMDP-LAYASWLSEKDTWGGAIELEILSFLYKTEIFALDLQSVTLQRFGTGMGYTVRAFLVYTGNHYDCIAMN---PAYN-SSSEREDQTLFSSRDENVLARAKRFVAEEGQKMKE-------- A0A3L6KWA4/90-263 -RYV-----PPVDGKWHFVRRVCP--SDNSCLFHAAAYVLRNKSRVDGPSLRKECADIVQAYPNVFNEKTILDRPNREYVDFIRNPNAWGGAIELMVLSFLTQTEIVALDLTSSNVLHFGEDNNYTVRAYVVFNGQHYDAIAMN---PMFN-SPQESEDQVLFSSTDAEVLNRARRFVADEAKKLR--------- D0A3Y1/90-263 -RYV-----PPVDGKWHFVRRVCP--SDNSCLFHAAAYVLRNKSRVDGPSLRKECADIVQAYPNVFNEKTILDRPNREYVDFIRNPNAWGGAIELMVLSFLTQTEIVALDLTSSNVLHFGEDNNYTVRAYVVFNGQHYDAIAMN---PMFN-SPQESEDQVLFSSTDAEVLNRARRFVADEAKKLR--------- A4IE15/211-381 ---------PPAPERAHLTRRRCP--ADNSCLFHACAYVLRDKSRTEGPQLRQECVQAVLDHPEMFNVNTLGMDP-LAYASWLSEKDTWGGAIELEILSFLYKTEIFALDLQSVTLQRFGTGMGYTVRAFLVYTGNHYDCIAMN---PVYN-PTSEREDQTLFSSRDENVLARAKRFVAEEGQKMKE-------- H0GFK1/90-263 PKRVLKSTEMSIGGSGENVLSVHPVPDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- A0A0L8VR40/90-263 PKRVLKSTEMSIGGSGENVLSVHPVPDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- A0A0L8RJV8/129-303 PKRVLKSTEMSIGGGGENVLSVHPVPDDNSCLFHAIAYCIFKQDNVR--ALREMVSKEVLSNPVKFSD-AILDKPNREYAQWILKMESWGGAIEIGIISDTLAVAIYVVDIDAVKIEKFNED-KFDNYILVLFNGIHYDSLTKNEFKTVFDKKNQPESDDVLTAA-------------LQLASNLKQTGYSF--- N1P319/90-263 PKRVLKSTEMSIGGSGENVLSVHPVLDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- B3LUG7/90-263 PKRVLKSTEMSIGGSGENVLSVHPVPDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- C8Z7N8/90-263 PKRVLKSTEMSIGGSGENVLSVHPVPDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- A7A1Z5/90-263 PKRVLKSTEMSIGGSGENVLSVHPVPDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- B5VHY3/90-263 PKRVLKSTEMSIGGSGENVLSVHPVPDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- G2WD97/90-263 PKRVLKSTEMSIGGSGENVLSVHPVPDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- C7GY70/90-263 PKRVLKSTEMSIGGSGENVLSVHPVPDDNSCLFHAIAYGIFKQDSVR--DLREMVSKEVLNNPVKFND-AILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNED-KFDNYILILFNGIHYDSLTMNEFKTVFN-KNQPESDDVLTAA-------------LQLASNLKQTGYSF--- #=GC scorecons 153622222465464454645559214999999994994645655652249954555496559449851675559445964674535599999964769454455856696466564595661475555566769499956679222667804465459569566121122122122255464677322222000 #=GC scorecons_70 ___*_________*____*____*___********_**_*__*__*____**______*___*__**__**___*___**_**_____*******_***______*__***__*____*__*__*______****_***_****____***_______*_**___________________*__**_________ #=GC scorecons_80 _______________________*___********_**____________**______*___*__**_______*___*_________******__*_*______*___*________*_____*_______*_*_***____*_____**_______*__*______________________**_________ #=GC scorecons_90 _______________________*___********_**____________**______*___*__**_______*___*_________******____*______*___*________*_______________*_***____*______*_______*__*_________________________________ //