# STOCKHOLM 1.0
#=GF ID 3.50.50.80/FF/000007
#=GF DE Ubiquitin-activating enzyme E1
#=GF AC 3.50.50.80/FF/000007
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 93.521
#=GS Q55C16/9-127      AC Q55C16
#=GS Q55C16/9-127      OS Dictyostelium discoideum
#=GS Q55C16/9-127      DE Ubiquitin-like modifier-activating enzyme 1
#=GS Q55C16/9-127      DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium discoideum; 
#=GS Q55C16/9-127      DR GO; GO:0005813; 
#=GS Q55C16/9-127      DR EC; 6.2.1.45; 
#=GS Q57XC5/1-118      AC Q57XC5
#=GS Q57XC5/1-118      OS Trypanosoma brucei brucei TREU927
#=GS Q57XC5/1-118      DE Ubiquitin-activating enzyme E1, putative
#=GS Q57XC5/1-118      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; 
#=GS Q57XC5/1-118      DR GO; GO:0004839; GO:0005654; GO:0005737; GO:0006464; 
#=GS Q9NF77/2-116      AC Q9NF77
#=GS Q9NF77/2-116      OS Leishmania major
#=GS Q9NF77/2-116      DE Putative ubiquitin-activating enzyme e1
#=GS Q9NF77/2-116      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania major species complex; Leishmania major; 
#=GS Q9NF77/2-116      DR GO; GO:0005654; GO:0005737; 
#=GS T1ELT8/1-117      AC T1ELT8
#=GS T1ELT8/1-117      OS Helobdella robusta
#=GS T1ELT8/1-117      DE Uncharacterized protein
#=GS T1ELT8/1-117      DR ORG; Eukaryota; Metazoa; Annelida; Clitellata; Hirudinea; Hirudinida; Glossiphoniiformes; Glossiphoniidae; Helobdella; Helobdella robusta; 
#=GS A7SBV9/1-108      AC A7SBV9
#=GS A7SBV9/1-108      OS Nematostella vectensis
#=GS A7SBV9/1-108      DE Predicted protein
#=GS A7SBV9/1-108      DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; 
#=GS Q550P6/28-155     AC Q550P6
#=GS Q550P6/28-155     OS Dictyostelium discoideum
#=GS Q550P6/28-155     DE Uncharacterized protein
#=GS Q550P6/28-155     DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium discoideum; 
#=GS A9TU56/19-137     AC A9TU56
#=GS A9TU56/19-137     OS Physcomitrella patens
#=GS A9TU56/19-137     DE Predicted protein
#=GS A9TU56/19-137     DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrella; Physcomitrella patens; 
#=GS A9T3V0/19-137     AC A9T3V0
#=GS A9T3V0/19-137     OS Physcomitrella patens
#=GS A9T3V0/19-137     DE Predicted protein
#=GS A9T3V0/19-137     DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrella; Physcomitrella patens; 
#=GS C4M7T9/1-119      AC C4M7T9
#=GS C4M7T9/1-119      OS Entamoeba histolytica
#=GS C4M7T9/1-119      DE Ubiquitin-activating enzyme, putative
#=GS C4M7T9/1-119      DR ORG; Eukaryota; Entamoebidae; Entamoeba; Entamoeba histolytica; 
#=GS F7C1J2/46-169     AC F7C1J2
#=GS F7C1J2/46-169     OS Monodelphis domestica
#=GS F7C1J2/46-169     DE Uncharacterized protein
#=GS F7C1J2/46-169     DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Didelphimorphia; Didelphidae; Didelphinae; Monodelphis; Monodelphis domestica; 
#=GS B0EFY1/1-119      AC B0EFY1
#=GS B0EFY1/1-119      OS Entamoeba dispar SAW760
#=GS B0EFY1/1-119      DE Ubiquitin-activating enzyme E1, putative
#=GS B0EFY1/1-119      DR ORG; Eukaryota; Entamoebidae; Entamoeba; Entamoeba dispar; 
#=GS F0ZL08/16-142     AC F0ZL08
#=GS F0ZL08/16-142     OS Dictyostelium purpureum
#=GS F0ZL08/16-142     DE Uncharacterized protein
#=GS F0ZL08/16-142     DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium purpureum; 
#=GS A4I0A5/2-116      AC A4I0A5
#=GS A4I0A5/2-116      OS Leishmania infantum
#=GS A4I0A5/2-116      DE Putative ubiquitin-activating enzyme e1
#=GS A4I0A5/2-116      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; 
#=GS E9AW70/2-119      AC E9AW70
#=GS E9AW70/2-119      OS Leishmania mexicana MHOM/GT/2001/U1103
#=GS E9AW70/2-119      DE Putative ubiquitin-activating enzyme e1
#=GS E9AW70/2-119      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania mexicana; 
#=GS A0A3L6L699/1-118  AC A0A3L6L699
#=GS A0A3L6L699/1-118  OS Trypanosoma brucei equiperdum
#=GS A0A3L6L699/1-118  DE Ubiquitin-activating enzyme E1
#=GS A0A3L6L699/1-118  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei equiperdum; 
#=GS E9BG91/2-116      AC E9BG91
#=GS E9BG91/2-116      OS Leishmania donovani BPK282A1
#=GS E9BG91/2-116      DE Ubiquitin-activating enzyme e1, putative
#=GS E9BG91/2-116      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; 
#=GS A0A175JW95/1-119  AC A0A175JW95
#=GS A0A175JW95/1-119  OS Entamoeba histolytica
#=GS A0A175JW95/1-119  DE Ubiquitin-activating enzyme putative
#=GS A0A175JW95/1-119  DR ORG; Eukaryota; Entamoebidae; Entamoeba; Entamoeba histolytica; 
#=GS M2RVU6/1-119      AC M2RVU6
#=GS M2RVU6/1-119      OS Entamoeba histolytica KU27
#=GS M2RVU6/1-119      DE Ubiquitin-activating enzyme E1, putative
#=GS M2RVU6/1-119      DR ORG; Eukaryota; Entamoebidae; Entamoeba; Entamoeba histolytica; 
#=GS B0EMB5/1-119      AC B0EMB5
#=GS B0EMB5/1-119      OS Entamoeba dispar SAW760
#=GS B0EMB5/1-119      DE Ubiquitin-activating enzyme E1, putative
#=GS B0EMB5/1-119      DR ORG; Eukaryota; Entamoebidae; Entamoeba; Entamoeba dispar; 
#=GS F0ZAP3/9-128      AC F0ZAP3
#=GS F0ZAP3/9-128      OS Dictyostelium purpureum
#=GS F0ZAP3/9-128      DE Ubiquitin activating enzyme E1
#=GS F0ZAP3/9-128      DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium purpureum; 
#=GF SQ 20
Q55C16/9-127              -QEPKIDDALYSRQLYALSHETMKKITSTSVL------------VVGLQGLGIEIVKDLSLAGVKSVTLYDKELVEIKDLSSQFYFSPEQVG-KVGRADACFQKVVDLNNYVRIDVHNGELSDEFLKK-------FNVVV
Q57XC5/1-118              MTSEEQRRQLYNRQEYVVGTETQAKYGCTDVL------------VVGACGLGAEIIKNLTLTGVRSIKVLDNGLATLQDLGTNFFLTPADMG-K-PRAEVVAARAQELNRFVSVTAVDVPLH-EVIPA-------VHVVV
Q9NF77/2-116              LSEEEQKRQLYSRQEYVVGSETQAKYGSTHVL------------VVGATGLSAEIIKNVVLTGVKSVKVLDDAVVTIEDLGTNFFLRPDDVG-K-ARGAAVAQAAKELNRFVEVSSVSGDPL-LHIPA-------VH---
T1ELT8/1-117              --MSEIDEGLYSRQLYVLGKNAMKKLCDGDVL------------ICGMGGPGIEVAKNLALAGVGKIVIHDLKELTWKDLSSQFLAEESDIG-K-NRAVVSRQKLSELNPHVNVLAHVEVLNDDFIKS-------FTAVV
A7SBV9/1-108              ----------------MLGDQAMQKMAHASVF------------LSGVGGLGVEIAKNLTLAGIKSITLHDTRAASMADLGSQFFLREDDVTSSRNRAVASAGRVAELNPYVSVHTQTDALDENNLDVLKN----YQCVI
Q550P6/28-155             YRDNSLDDSLYSRQRYVLGDFAMSKLSKGDVF------------LSGLGGVGVEIAKNIILAGIKSITLHDTKEASIYDLSSQFYINPEHVDQKLNRAIISQSHLQELNPYVKVNTITNLSLSDLILNNSNSLLQFKCII
A9TU56/19-137             ALSKEANELWYSRLIYTLGRGAVNLLNQSRVL------------VLGCKGLGAEVAKNLVLSGVQGLGLVDDEVVVLADLGANFCLSEADVG-R-NRAVATAQKLKEMYPSADIVTLSSVAVESSLGS-------YGFIV
A9T3V0/19-137             APVKEMSELRYSRLIHTLGRDAVNALSQARVL------------VLGCKGSGVEVAKNLVLSGVQGLGLVDDEVVVLADLGAHFLLSEGDVG-R-NRAVATAQKLKEMYPSVNIVTLSSVSVESALGS-------YGCVV
C4M7T9/1-119              -MTQQIDEAVLSRQLFTIGKDAQIKMMNTKVL------------IAGLNGMGAEITKNVLLMSVKSVGLLDNRNACLADLGTNFFLRKEHIG-H-CISESTYKQFQELNNNVPVRVEKRELTDETLYND------YDIIV
F7C1J2/46-169             -NEADIDEGLYSRQLPVQG------LMPGPLLTLTPTPSNPYWSISGQLGPGGDSGQNIILGGVKAVTLHDQGAAQWADLSSQFYLREEDVG-K-NRAEVSQPRLAELNAYVPVCSYTGPLTEDFLSS-------FQVVV
B0EFY1/1-119              -MAQQIDEAVLSRQLFTIGKDAQIKMMNTKVL------------IAGLNGMGAEITKNVLLMSVKSVGLLDNRNACLADLGTNFFLRKEHIG-H-CISESTHKQFQELNNSVPVRVEKRELTDESLYND------YDIIV
F0ZL08/16-142             FRDNNLDDSLYSRQRYVLGDFAMSKLSKGDIF------------ISGIGGLGVEIAKNLILAGIKSITLHDCKLVSKYDLSSQFYLSHNQIG-KENRAVASHTNLQELNPYVKVNTFTESSLSELIKTNKNYFLQFKCII
A4I0A5/2-116              LSEEEQKRQLYSRQEYVVGSETQAKYGSTHVL------------VVGATGLSAEIIKNVVLTGVKSVKVLDDAVVTIEDLGTNFFLRPDDVG-K-ARGAAVAQAAKELNRFVEVSPVSGDPL-LHIPA-------VH---
E9AW70/2-119              LSEEEQKRQLYNRQEYVVGSETQAKYGSTHVL------------VVGATGLGAEIIKNVVLTGVKSVKVLDDAVVAIEDLGTNFFLQPDDLG-K-SRGAAVAQAAKELNRFVEVSSVSGDPL-SHIPA-------VHVVI
A0A3L6L699/1-118          MTSEEQRRQLYNRQEYVVGTETQAKYGCTDVL------------VVGACGLGAEIIKNLTLTGVRSIKVLDNGLATLQDLGTNFFLTPADMG-K-PRAEVVAARAQELNRFVSVTAVDVPLH-EVIPA-------VHVVV
E9BG91/2-116              LSEEEQKRQLYSRQEYVVGSETQAKYGSTHVL------------VVGATGLSAEIIKNVVLTGVKSVKVLDDAVVTIEDLGTNFFLRPDDVG-K-ARGAAVAQAAKELNRFVEVSSVSGDPL-LHIPA-------VH---
A0A175JW95/1-119          -MTQQIDEAVLSRQLFTIGKDAQIKMMNTKVL------------IAGLNGMGAEITKNVLLMSVKSVGLLDNRNACLADLGTNFFLRKEHIG-H-CISESTYKQFQELNNNVPVRVEKRELTDETLYND------YDIIV
M2RVU6/1-119              -MTQQIDEAVLSRQLFTIGKDAQIKMMNTKVL------------IAGLNGMGAEITKNVLLMSVKSVGLLDNRNACLADLGTNFFLRKEHIG-H-CISESTYKQFQELNNNVPVRVEKRELTDETLYND------YDIIV
B0EMB5/1-119              -MTQQIDEAVLSRQLFTIGKDAQIKMMNTKVL------------IAGLNGMGAEITKNVLLMSVKSVGLLDNRNACLADLGTNFFLRKEHIG-H-CISESTYKQFQELNNSVPVRVEKRELTDESLYND------YDIIV
F0ZAP3/9-128              EQEVKIDDALYSRQLYVLSHEAMKKILSTSIL------------VVGLQGLGIEIVKDLVLAGVKSVTLYDNELVQIQDLSSQFYFSPDQVG-KVSRSKACVQKVVDLNNYVRIESYEGELTDEYLKK-------FNVVV
#=GC scorecons            02334344355676355573454364335377000000000000649339575874886494776664649443534499655966444567050465454344448874483734333353343624000000054355
#=GC scorecons_70         ___________***____*_____*_____**____________*_*__*_*_**_**__*_*****_*_*_______***__***____**______________***__*_*___________*______________
#=GC scorecons_80         ____________*_____*___________**______________*__*_*_**_**__*__*______*_______**___*_______*______________***__*_*__________________________
#=GC scorecons_90         ______________________________________________*__*___*__*___*_________*_______**___*______________________**___*____________________________
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