# STOCKHOLM 1.0 #=GF ID 3.40.50.720/FF/000663 #=GF DE Multifunctional enzyme siroheme synthase CYSG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase #=GF AC 3.40.50.720/FF/000663 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 45.651 #=GS P95077/6-129 AC P95077 #=GS P95077/6-129 OS Mycobacterium tuberculosis CDC1551 #=GS P95077/6-129 DE Uroporphyrinogen III methyltransferase #=GS P95077/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; Mycobacterium tuberculosis; #=GS P95077/6-129 DR GO; GO:0005618; GO:0005886; #=GS Q9L1C9/6-132 AC Q9L1C9 #=GS Q9L1C9/6-132 OS Streptomyces coelicolor A3(2) #=GS Q9L1C9/6-132 DE Putative uroporphyrin-III methyltransferase #=GS Q9L1C9/6-132 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group; Streptomyces coelicolor; #=GS I6X5I7/6-129 AC I6X5I7 #=GS I6X5I7/6-129 OS Mycobacterium tuberculosis H37Rv #=GS I6X5I7/6-129 DE Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatas... #=GS I6X5I7/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; Mycobacterium tuberculosis; #=GS D6ENV4/6-132 AC D6ENV4 #=GS D6ENV4/6-132 OS Streptomyces lividans TK24 #=GS D6ENV4/6-132 DE Uroporphyrin-III methyltransferase #=GS D6ENV4/6-132 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces lividans; #=GS A0A1D8SL58/6-132 AC A0A1D8SL58 #=GS A0A1D8SL58/6-132 OS Streptomyces olivaceus #=GS A0A1D8SL58/6-132 DE Uroporphyrinogen-III C-methyltransferase #=GS A0A1D8SL58/6-132 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces olivaceus; #=GS A0A1X0K906/6-129 AC A0A1X0K906 #=GS A0A1X0K906/6-129 OS Mycobacterium shinjukuense #=GS A0A1X0K906/6-129 DE Uroporphyrinogen-III C-methyltransferase #=GS A0A1X0K906/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium shinjukuense; #=GS G0TFE6/6-129 AC G0TFE6 #=GS G0TFE6/6-129 OS Mycobacterium canettii CIPT 140010059 #=GS G0TFE6/6-129 DE Putative multifunctional enzyme siroheme synthase CYSG: uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase #=GS G0TFE6/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; Mycobacterium canettii; #=GS A0A1R3Y2D0/6-129 AC A0A1R3Y2D0 #=GS A0A1R3Y2D0/6-129 OS Mycobacterium tuberculosis variant bovis AF2122/97 #=GS A0A1R3Y2D0/6-129 DE POSSIBLE MULTIFUNCTIONAL ENZYME SIROHEME SYNTHASE CYSG: UROPORPHYRIN-III C-METHYLTRANSFERASE (UROGEN III METHYLASE) (SUMT) (UROPORPHYRINOGEN III METHYLASE) (UROM) + PRECORRIN-2 OXIDASE + FERROCHELATASE #=GS A0A1R3Y2D0/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; Mycobacterium tuberculosis; #=GS A5U6J9/6-129 AC A5U6J9 #=GS A5U6J9/6-129 OS Mycobacterium tuberculosis H37Ra #=GS A5U6J9/6-129 DE Uroporphyrinogen III methyltransferase #=GS A5U6J9/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; Mycobacterium tuberculosis; #=GS A0A045IEG0/6-129 AC A0A045IEG0 #=GS A0A045IEG0/6-129 OS Mycobacterium tuberculosis #=GS A0A045IEG0/6-129 DE Multifunctional enzyme siroheme synthase CYSG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase #=GS A0A045IEG0/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; Mycobacterium tuberculosis; #=GS A0A0H3M9R7/6-129 AC A0A0H3M9R7 #=GS A0A0H3M9R7/6-129 OS Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 #=GS A0A0H3M9R7/6-129 DE Possible multifunctional enzyme siroheme synthase cysG: uroporphyrin-iii c-methyltransferase + precorrin-2 oxidase + ferrochelatase #=GS A0A0H3M9R7/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; Mycobacterium tuberculosis; #=GS A0A0H3LH47/6-129 AC A0A0H3LH47 #=GS A0A0H3LH47/6-129 OS Mycobacterium tuberculosis str. Erdman = ATCC 35801 #=GS A0A0H3LH47/6-129 DE Multifunctional uroporphyrinogen IIImethylase/precorrin-2 oxidase/ferrochelatase #=GS A0A0H3LH47/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; Mycobacterium tuberculosis; #=GS A0A328GDZ2/6-129 AC A0A328GDZ2 #=GS A0A328GDZ2/6-129 OS Mycobacterium tuberculosis variant pinnipedii #=GS A0A328GDZ2/6-129 DE Uroporphyrinogen-III C-methyltransferase #=GS A0A328GDZ2/6-129 DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; Mycobacterium tuberculosis; #=GF SQ 13 P95077/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGG Q9L1C9/6-132 AYPVGLRLAGRRVVVLGGGQVAQRRLPALVAAGADIRLVSPEATPSVEAMADAGEITWEQRPYAEGDLADAWYALIATSDTAANDAASAEGERHRVWCVRSDDADRATAWTPATGHSEGVTVAVLTT- I6X5I7/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGG D6ENV4/6-132 AYPVGLRLAGRRVVVLGGGQVAQRRLPALVAAGADIRLVSPEATPSVEAMADAGEITWEQRPYAEGDLADAWYALIATSDTAANDAASAEGERHRVWCVRSDDADRATAWTPATGHSEGVTVAVLTT- A0A1D8SL58/6-132 AYPVGLRLTGRRVVVLGGGQVAQRRLPALIAAGADIRLVSPEATPSVEAMADTGEITWERRPYTEGDLAGAWYVLIATSDAEAAEAASAEAERHRVWCVRSDDADRATAWTPATGHSEGVTVAVLTT- A0A1X0K906/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIARTVTPAVEAM---QHLTLALRDYRDGDLDGAWYAIAATDDAQVNVAVVAEAERRRIFCVRADVAVEGTAVTPATFGYAGLSVGVLAGG G0TFE6/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGG A0A1R3Y2D0/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGG A5U6J9/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGG A0A045IEG0/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGG A0A0H3M9R7/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGG A0A0H3LH47/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGG A0A328GDZ2/6-129 -YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGG #=GC scorecons 19599999796699969995999999959795999666658459959999111558944394946999569997659959645749559969969659995949455994999634559659599652 #=GC scorecons_70 _*_****************_*******_***_*******_*__**_****_____**___*_*_****_******_**_**__*_*__********_***_*_*___**_***_____**_*_***__ #=GC scorecons_80 _*_*******__***_***_*******_***_***_____*__**_****_____**___*_*__***__****__**_*_____*__**_**_*__***_*_*___**_***_____*__*_**___ #=GC scorecons_90 _*_*****_*__***_***_*******_*_*_***________**_****_____**___*_*__***__***___**_*_____*__**_**_*__***_*_*___**_***_____*__*_**___ //