# STOCKHOLM 1.0
#=GF ID 3.40.50.720/FF/000593
#=GF DE Dihydrofolate reductase
#=GF AC 3.40.50.720/FF/000593
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 82.472
#=GS Q9Z569/97-285       AC Q9Z569
#=GS Q9Z569/97-285       OS Streptomyces coelicolor A3(2)
#=GS Q9Z569/97-285       DE Putative dehydrogenase
#=GS Q9Z569/97-285       DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group; Streptomyces coelicolor; 
#=GS Q9FC67/100-287      AC Q9FC67
#=GS Q9FC67/100-287      OS Streptomyces coelicolor A3(2)
#=GS Q9FC67/100-287      DE Putative dehydrogenase
#=GS Q9FC67/100-287      DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group; Streptomyces coelicolor; 
#=GS Q9RTQ5/98-282       AC Q9RTQ5
#=GS Q9RTQ5/98-282       OS Deinococcus radiodurans R1
#=GS Q9RTQ5/98-282       DE 2-hydroxyacid dehydrogenase, putative
#=GS Q9RTQ5/98-282       DR ORG; Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae; Deinococcus; Deinococcus radiodurans; 
#=GS A0A2K3E609/111-284  AC A0A2K3E609
#=GS A0A2K3E609/111-284  OS Chlamydomonas reinhardtii
#=GS A0A2K3E609/111-284  DE Uncharacterized protein
#=GS A0A2K3E609/111-284  DR ORG; Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas; Chlamydomonas reinhardtii; 
#=GS A8HPR9/63-236       AC A8HPR9
#=GS A8HPR9/63-236       OS Chlamydomonas reinhardtii
#=GS A8HPR9/63-236       DE Predicted protein
#=GS A8HPR9/63-236       DR ORG; Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas; Chlamydomonas reinhardtii; 
#=GS A0A3Q8VSB3/97-286   AC A0A3Q8VSB3
#=GS A0A3Q8VSB3/97-286   OS Streptomyces sp. KPB2
#=GS A0A3Q8VSB3/97-286   DE Dihydrofolate reductase
#=GS A0A3Q8VSB3/97-286   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. KPB2; 
#=GS A0A397QC74/97-285   AC A0A397QC74
#=GS A0A397QC74/97-285   OS Streptomyces sp. 19
#=GS A0A397QC74/97-285   DE Phosphoglycerate dehydrogenase-like enzyme
#=GS A0A397QC74/97-285   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. 19; 
#=GS A0A1H2CYE8/97-285   AC A0A1H2CYE8
#=GS A0A1H2CYE8/97-285   OS Streptomyces sp. 2114.2
#=GS A0A1H2CYE8/97-285   DE Phosphoglycerate dehydrogenase
#=GS A0A1H2CYE8/97-285   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. 2114.2; 
#=GS A0A2P8A6P6/97-285   AC A0A2P8A6P6
#=GS A0A2P8A6P6/97-285   OS Streptomyces sp. 111WW2
#=GS A0A2P8A6P6/97-285   DE Glyoxylate/hydroxypyruvate reductase B
#=GS A0A2P8A6P6/97-285   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. 111WW2; 
#=GS A0A3E0GLE6/97-285   AC A0A3E0GLE6
#=GS A0A3E0GLE6/97-285   OS Streptomyces sp. 2221.1
#=GS A0A3E0GLE6/97-285   DE Phosphoglycerate dehydrogenase-like enzyme
#=GS A0A3E0GLE6/97-285   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. 2221.1; 
#=GS A0A0K2AZ56/97-285   AC A0A0K2AZ56
#=GS A0A0K2AZ56/97-285   OS Streptomyces ambofaciens ATCC 23877
#=GS A0A0K2AZ56/97-285   DE Putative dehydrogenase
#=GS A0A0K2AZ56/97-285   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces ambofaciens; 
#=GS A0A429NMG5/97-285   AC A0A429NMG5
#=GS A0A429NMG5/97-285   OS Streptomyces sp. WAC08401
#=GS A0A429NMG5/97-285   DE Dihydrofolate reductase
#=GS A0A429NMG5/97-285   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. WAC08401; 
#=GS A0A1D8SVB0/93-281   AC A0A1D8SVB0
#=GS A0A1D8SVB0/93-281   OS Streptomyces olivaceus
#=GS A0A1D8SVB0/93-281   DE Dihydrofolate reductase
#=GS A0A1D8SVB0/93-281   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces olivaceus; 
#=GS A0A1S6J6Q1/97-285   AC A0A1S6J6Q1
#=GS A0A1S6J6Q1/97-285   OS Streptomyces pactum
#=GS A0A1S6J6Q1/97-285   DE Dihydrofolate reductase
#=GS A0A1S6J6Q1/97-285   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces pactum; 
#=GS M3E773/100-287      AC M3E773
#=GS M3E773/100-287      OS Streptomyces gancidicus BKS 13-15
#=GS M3E773/100-287      DE Dehydrogenase
#=GS M3E773/100-287      DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces gancidicus; 
#=GS A0A3Q8VZC7/100-287  AC A0A3Q8VZC7
#=GS A0A3Q8VZC7/100-287  OS Streptomyces sp. KPB2
#=GS A0A3Q8VZC7/100-287  DE Dihydrofolate reductase
#=GS A0A3Q8VZC7/100-287  DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. KPB2; 
#=GF SQ 16
Q9Z569/97-285               --EASTAELTLALILASLRGIPD----FVRAQDRGEWL-----GGFRPALADRTVLIVGYGSIGAAIEDRLVPFEVAPVVRVARSARTTERGPVHPLTELPRLLPQADVVILSTPLTEATRGLAGAEFLARMKDGALLVNVARGPVVDTKALLAELESGRL-TAALDVTDPEPLPPGHPLWHAPGIVVSPHAGGPTSAFLP
Q9FC67/100-287              --APSTAELALTLILASLRGIPE----SVRAQDGGAWG-----PEVFPSLYGRSVLVVGYGAVGSALEELLVPFGCA-VTRVAGADRDAPRGPVRSAAHLPRLVSDADVVVLSTPLTPQTRQLFDAGMLARMKDGALLVNVARGAVVDTDALLKETHEGRL-RAALDVTDPEPLPPGHPLRETPGVLITPHVGAFTSSLWP
Q9RTQ5/98-282               --DRAVAVHVVAGMLAASRGLHR----FRDAQQRGEWVRTSLADTGLSTLDGQKVVLWGYGHIGKIVEELLAPFGAQVYGLTSKTEP----------DLVDYRLAEADWVVLLLPSTERTRGIVNAERLTALKPGVWLSNQGRGDLIVTDDLLAALDSGHLGGAVLDVTDPEPLLAGHPLWDRENVVITPHIASITSDLLE
A0A2K3E609/111-284          YNSHSVAEVALMMILMLSRKVDEARAVFARRERIGEPV-----GG---ELHGKTLGVVGMGKIGSCLAEAARGLGMQVLGVTSRSSR----------AELEALLAASHVVALHCPLSPATRGLIGRAELALMRPGALLLNCARGSVVDREALWEALQSGRLGGVGLDTHWVEPAPRDDPLYSHPRVLALPHL---------
A8HPR9/63-236               YNSHSVAEVALMMILMLSRKVDEARAVFARRERIGEPV-----GG---ELHGKTLGVVGMGKIGSCLAEAARGLGMQVLGVTSRSSR----------AELEALLAASHVVALHCPLSPATRGLIGRAELALMRPGALLLNCARGSVVDREALWEALQSGRLGGVGLDTHWVEPAPRDDPLYSHPRVLALPHL---------
A0A3Q8VSB3/97-286           --EASTAELTLALILASLRGIPD----FVRAQDRGEWL----GGGFRLALADRTVLIVGYGSIGAAIEDRLVPFEVAPVVRVARSARATERGPVHPLTELPDLLPQADVVVLATPLTEATRSLVDATFLARMKDGALLVNVARGPVVDTKALLAELESGRL-TAALDVTDPEPLPPGHPLWNAPGTVVSPHAGGPTSAFLP
A0A397QC74/97-285           --EASTAELTLALILASLRGIPD----FVRAQDRGEWL-----GGFRPALADRTVLIVGYGSIGAAIEDRLVPFEVAPVVRVARSARTTERGPVHPLTELPRLLPQADVVILSTPLTEATRGLAGAEFLARMKDGALLVNVARGPVVDTKALLAELESGRL-TAALDVTDPEPLPPGHPLWHAPGIVVSPHAGGPTSAFLP
A0A1H2CYE8/97-285           --EASTAELTLALILASLRGIPD----FVRAQDRGEWL-----GGFRPALADRTVLIVGYGSIGAAIEDRLVPFEVAPVVRVARSARTTERGPVHPLTELPRLLPQADVVILSTPLTEATRGLAGAEFLARMKDGALLVNVARGPVVDTKALLAELESGRL-TAALDVTDPEPLPPGHPLWHAPGIVVSPHAGGPTSAFLP
A0A2P8A6P6/97-285           --EASTAELTLALILASLRGIPD----FVRAQDRGEWL-----GGFRPALADRTVLIVGYGSIGAAIEDRLVPFEVAPVVRVARSARTTERGPVHPLTELPRLLPQADVVILSTPLTEATRGLAGAEFLARMKDGALLVNVARGPVVDTKALLAELESGRL-TAALDVTDPEPLPPGHPLWHAPGIVVSPHAGGPTSAFLP
A0A3E0GLE6/97-285           --EASTAELTLALILASLRGIPD----FVRAQDRGEWL-----GGFRPALADRTVLIVGYGSIGAAIEDRLVPFEVAPVVRVARSARTTERGPVHPLTELPRLLPQADVVILSTPLTEATRGLAGAEFLARMKDGALLVNVARGPVVDTKALLAELESGRL-TAALDVTDPEPLPPGHPLWHAPGIVVSPHAGGPTSAFLP
A0A0K2AZ56/97-285           --EASTAELTLTLILASLRGVPD----FVRAQDRGEWL-----GGFRPALADRKVLIVGYGSIGAAIEDRLVPFEVAPVVRVARSARTTARGPVHPLTELPALLPEADVVILSTPLTEATRGLADADFLARMKDGALLGNVARGPVVDTKALLTELESGRL-TAALDVTDPEPLPPGHPLWQAPGVLVSPHAGGPTSAFLP
A0A429NMG5/97-285           --EASTAELTLALILASLRGVPD----FVRAQGRGEWL-----GGFRPALADRKVLIVGYGSIGAAIEDRLVPFEVAPVVRVARSARTTARGPVHPLTELPALLPEADVVVLSTPLTEETRGLVDAEFLARMKDGALLVNVARGPVVDTKALLTELESGRI-TAALDVTDPEPLPPGHPLWHAPGVLVSPHAGGPTSAFLP
A0A1D8SVB0/93-281           --EASTAELTLTLILASLRGVPD----FVRAQDRGEWL-----GGFRPALADRTVLIVGYGSIGAAIEDRLVPFEVAPVVRVARSARATERGPVHPLTDLPALLPRADVVVLSTPLTEATRGLVDAEFLARMKDGALLVNVARGPVVDTKALLTELENGRL-TAALDVTDPEPLPTDHPLWHAPGIVVSPHAGGPTSAFLP
A0A1S6J6Q1/97-285           --EASTAELTLALILASLRGIPD----FVRAQDRGEWL-----GGFRPALADRKVLVVGYGSIGAAIEDRLVPFEVAPVVRVARSARTTARGPVHPLTELPALLPEADVVVVSTPLTEATRGLVDADFLTRMKDGALLVNVARGPVVDTKALLAELESGRL-TAALDVTDPEPLPPGHPLWQAPGVLVSPHAGGPTSAFLP
M3E773/100-287              --APSTAELALALILASLRGIPE----SVRAQDGGAWR-----PEVFPSLYGRSVLIVGYGAVGSALEDLLVPFGCA-VTRVAGTDRDAPRGPVRSAAHLPRLVADADVVVLSVPLTPQTRQLFDAGMLAGMKDGALLVNVARGAVVDTDALLKETHEGRL-RAALDVTDPEPLPPGHPLRETPGVLITPHVGAFTSSLWP
A0A3Q8VZC7/100-287          --APSTAELALTLILASLRGIPE----SVRAQDGGAWR-----PEVFPSLYGRSVLVVGYGAVGSALEELLVPFGCA-VTRVAGTDRDAPRGPVRSAAHLPRLVADADVVVLSVPLTPQTRQLFDAGMLARMKDGALLVNVARGAVVDTDALLKETHEGRL-RAALDVTDPEPLPPGHPLRETPGVLITPHVGAFTSSLWP
#=GC scorecons              004475975575589655966560000657675496540000055223493664746795947955667365676453544566647221333322255754775466795844976559967456439748759779594799478765796456569780465996656996756699444757654994432553333
#=GC scorecons_70           ____*_**__*__***__***______*_***__**_____________*__*_*_***_*_**___**_*_**____________*____________*__**__****_*__***__**_*__*__**_**_****_*_***_****_**___*__***__*_****_*****_****___*_**__**__________
#=GC scorecons_80           ____*_**__*__**___*__________*____*______________*________*_*_**______________________*____________*___*_____*_*__**___**_*_____**_**_****_*_***_**___**______***____**____**_*___**___*_____**__________
#=GC scorecons_90           ______*_______*___*_______________*______________*________*_*__*_____________________________________________*_*__*____**_______*_____*__*_*__**__*____*______*_*____**____**_____**_________**__________
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