# STOCKHOLM 1.0 #=GF ID 3.40.50.2300/FF/000253 #=GF DE Extracellular calcium-sensing receptor #=GF AC 3.40.50.2300/FF/000253 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 96.545 #=GS A7RX43/199-334_462-479 AC A7RX43 #=GS A7RX43/199-334_462-479 OS Nematostella vectensis #=GS A7RX43/199-334_462-479 DE Predicted protein #=GS A7RX43/199-334_462-479 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS W4ZBX7/167-303_440-448 AC W4ZBX7 #=GS W4ZBX7/167-303_440-448 OS Strongylocentrotus purpuratus #=GS W4ZBX7/167-303_440-448 DE Uncharacterized protein #=GS W4ZBX7/167-303_440-448 DR ORG; Eukaryota; Metazoa; Echinodermata; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; Strongylocentrotus; Strongylocentrotus purpuratus; #=GS B3S2J5/220-354_483-494 AC B3S2J5 #=GS B3S2J5/220-354_483-494 OS Trichoplax adhaerens #=GS B3S2J5/220-354_483-494 DE Uncharacterized protein #=GS B3S2J5/220-354_483-494 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS A7S0L3/181-317 AC A7S0L3 #=GS A7S0L3/181-317 OS Nematostella vectensis #=GS A7S0L3/181-317 DE Predicted protein #=GS A7S0L3/181-317 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7S1X6/186-322_459-481 AC A7S1X6 #=GS A7S1X6/186-322_459-481 OS Nematostella vectensis #=GS A7S1X6/186-322_459-481 DE Predicted protein #=GS A7S1X6/186-322_459-481 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7SD73/163-299_429-435 AC A7SD73 #=GS A7SD73/163-299_429-435 OS Nematostella vectensis #=GS A7SD73/163-299_429-435 DE Predicted protein #=GS A7SD73/163-299_429-435 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7RR90/186-323_454-465 AC A7RR90 #=GS A7RR90/186-323_454-465 OS Nematostella vectensis #=GS A7RR90/186-323_454-465 DE Predicted protein #=GS A7RR90/186-323_454-465 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7RR89/139-275_408-420 AC A7RR89 #=GS A7RR89/139-275_408-420 OS Nematostella vectensis #=GS A7RR89/139-275_408-420 DE Predicted protein #=GS A7RR89/139-275_408-420 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7RZI9/188-324_457-474 AC A7RZI9 #=GS A7RZI9/188-324_457-474 OS Nematostella vectensis #=GS A7RZI9/188-324_457-474 DE Predicted protein #=GS A7RZI9/188-324_457-474 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7RMV4/154-299_426-445 AC A7RMV4 #=GS A7RMV4/154-299_426-445 OS Nematostella vectensis #=GS A7RMV4/154-299_426-445 DE Predicted protein #=GS A7RMV4/154-299_426-445 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7RSA2/185-321_447-466 AC A7RSA2 #=GS A7RSA2/185-321_447-466 OS Nematostella vectensis #=GS A7RSA2/185-321_447-466 DE Predicted protein #=GS A7RSA2/185-321_447-466 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7S0L2/181-317_442-461 AC A7S0L2 #=GS A7S0L2/181-317_442-461 OS Nematostella vectensis #=GS A7S0L2/181-317_442-461 DE Predicted protein #=GS A7S0L2/181-317_442-461 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS B3RUD6/167-301_432-442 AC B3RUD6 #=GS B3RUD6/167-301_432-442 OS Trichoplax adhaerens #=GS B3RUD6/167-301_432-442 DE Uncharacterized protein #=GS B3RUD6/167-301_432-442 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS B3S610/166-300_433-453 AC B3S610 #=GS B3S610/166-300_433-453 OS Trichoplax adhaerens #=GS B3S610/166-300_433-453 DE Uncharacterized protein #=GS B3S610/166-300_433-453 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS A7S0D3/205-343_497-519 AC A7S0D3 #=GS A7S0D3/205-343_497-519 OS Nematostella vectensis #=GS A7S0D3/205-343_497-519 DE Predicted protein #=GS A7S0D3/205-343_497-519 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7S0J8/156-290_435-455 AC A7S0J8 #=GS A7S0J8/156-290_435-455 OS Nematostella vectensis #=GS A7S0J8/156-290_435-455 DE Predicted protein #=GS A7S0J8/156-290_435-455 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS B3S462/177-313_445-455 AC B3S462 #=GS B3S462/177-313_445-455 OS Trichoplax adhaerens #=GS B3S462/177-313_445-455 DE Uncharacterized protein #=GS B3S462/177-313_445-455 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS B3RWY5/139-275_402-421 AC B3RWY5 #=GS B3RWY5/139-275_402-421 OS Trichoplax adhaerens #=GS B3RWY5/139-275_402-421 DE Uncharacterized protein #=GS B3RWY5/139-275_402-421 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS B3S157/187-322_446-466 AC B3S157 #=GS B3S157/187-322_446-466 OS Trichoplax adhaerens #=GS B3S157/187-322_446-466 DE Uncharacterized protein #=GS B3S157/187-322_446-466 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS A0A369SLR2/220-354_483-494 AC A0A369SLR2 #=GS A0A369SLR2/220-354_483-494 OS Trichoplax sp. H2 #=GS A0A369SLR2/220-354_483-494 DE Extracellular calcium-sensing receptor #=GS A0A369SLR2/220-354_483-494 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax sp. H2; #=GS A0A369SI03/215-349_480-490 AC A0A369SI03 #=GS A0A369SI03/215-349_480-490 OS Trichoplax sp. H2 #=GS A0A369SI03/215-349_480-490 DE Metabotropic glutamate receptor 8 #=GS A0A369SI03/215-349_480-490 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax sp. H2; #=GS A0A369RPI5/204-338_471-491 AC A0A369RPI5 #=GS A0A369RPI5/204-338_471-491 OS Trichoplax sp. H2 #=GS A0A369RPI5/204-338_471-491 DE Extracellular calcium-sensing receptor #=GS A0A369RPI5/204-338_471-491 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax sp. H2; #=GS A0A369S5E3/233-369_501-511 AC A0A369S5E3 #=GS A0A369S5E3/233-369_501-511 OS Trichoplax sp. H2 #=GS A0A369S5E3/233-369_501-511 DE Metabotropic glutamate receptor #=GS A0A369S5E3/233-369_501-511 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax sp. H2; #=GS A0A369SCE0/206-342_469-488 AC A0A369SCE0 #=GS A0A369SCE0/206-342_469-488 OS Trichoplax sp. H2 #=GS A0A369SCE0/206-342_469-488 DE Extracellular calcium-sensing receptor #=GS A0A369SCE0/206-342_469-488 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax sp. H2; #=GS A0A369SRG8/208-343_467-487 AC A0A369SRG8 #=GS A0A369SRG8/208-343_467-487 OS Trichoplax sp. H2 #=GS A0A369SRG8/208-343_467-487 DE Extracellular calcium-sensing receptor #=GS A0A369SRG8/208-343_467-487 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax sp. H2; #=GF SQ 25 A7RX43/199-334_462-479 FQSHAMVDIIMHYEWSCVALIGTDD-VYGRSGVNTFVEAG-KASNLCIA-SMDLFPVHD---------YQEKIKEIIIKLKGMVHVDIIVLYSLSAQAVNIFDEALEQGMTGKTWIASDGWARSPL-VRQSRYIPII---QGTIGLEF--RDVKDVLNIQLHGKE---LNAVNVG------------ W4ZBX7/167-303_440-448 FQARAMAHLANHFGFHTVALLGNDEGAYGVSGVYVFEDEA-SKHNICIA-YKKIFGVSD---------DRSDFERIVTDLRQIPDVRVIVAFANEAPMNQLLTYFAENNVTGYMWIGSDGWGASKT-VLDPKISRVT---SGMIGVFP--HTETDFYNLQPKY------------------------ B3S2J5/220-354_483-494 FQGRAVTAVIHYFGWNYTAVLWEDD-DYGNSLVEEFQRSA-KEKNVCIS-KVILFPKRP---------TASQLQSIIKELRAL-KVTVVFIASNAKMAHEYFIQATIANFTGITYIAPISWSQSSS-IISEIDSDII---GGTIGLTL--GSSKNIVNLQPNGKN-V-------------------- A7S0L3/181-317 EQSKAMADIIEHFKWAYVAAIAHDG-SYGQYGVRALEREAYDRKTFCIS-FVEFFTRSG---------YKGKIETIVRKIKRASNIKVIVFWSNFDQADVFLEEALKQKLNDRTFLLSEAMATFGM-QIMRKYTSVL---GGSLAILP--HEYR--------------------------------- A7S1X6/186-322_459-481 ---------IDKFEWNYVAAVAMEH-SYGIYGIRALEREALQRQTFCIG-FTEYIPPQD---------YSLQIPGIVQKLKHSKEVKVVILWIEDSVARVLMHEAARQGVQYRVWILSDSLATKTP-DFLGSDFIYL---GVYLGIQP--RQFRDEKYEKHLKSG-ISYSKVKVGTWNKTRDSRLQI A7SD73/163-299_429-435 QQAKALADIIDYFEWKYVTVIGVDT-SYGRYGVMGLENEAQERGTFCIA-QVSYFPSTG---------YQTKIASLVTKIKTANDVNVIVLWGDPTTSIAFLEEVRKQGVTGKTWLAPEGWSEATS-LFKPKYMPII---GGFVGTKL--RDYDDLVNLHP-------------------------- A7RR90/186-323_454-465 YQAKAMADLIERFNWSYIGAVVVDH-SYGRYGIRALEQESYDRKSFCIA-ATEFLPRSG---------FEKKLGVVISTLASKKNIKVIVLWTTETLGKNFLKEAKKQGLTHRTWILSEALATYKAKGFFSEYLSPY---DHYFGIQP--KLWEEVVSFKTFEDG-T-------------------- A7RR89/139-275_408-420 NQAKSIVDIIEYFNWSYVAAAAVDH-SYGRYGMRALEKEAEERKTFCLA-FTEYFTRTG---------YKNKVYDIVLRLKNNPNIKVVVLWSTEEPARRFLQEAIRQNLEGRTFLISESLATNEQ-EFFHKFSTVI---DGCLGTVP--YYRNQIINAQKVSAD-RM------------------- A7RZI9/188-324_457-474 EQAKAMASIIEHFGWTYVAVLALDT-TYGQYGVRALQRVSFRRKTFCIA-LTEFFTETG---------YNGQFMHIITKLKLLKNTKVVVLWADHESAKAFLYEAERRELFGRTFLMSEAMSTVDA-GVLARHEAVL---RGALGVVP--HKFRDFINFQERGGD---YAIVKIG------------ A7RMV4/154-299_426-445 QQAKAMVDIIEHFGWKYVAAVAVDH-SYGRYGVRALEKEAYNRGSFCIA-FVDYFTRSGELIGQNRSSYMGKITSIIQKLKRETNIRVIVFWSSYEPAKRFLEEASAQGMTGRTFLMSEAMATIAQ-DLLQRHVDVL---NGSIGLMP--HRYRDVVHFRSSETT-GPFSVQIVG------------ A7RSA2/185-321_447-466 EQSKAMADIIDHFNWSYVAAVAHDG-SYGQHGVRALEREAYNRQTFCIA-FVEFFTTSG---------YKGKVEEIVRKIKRQTSVKVIVFWSNYYQTHAFLSEATKQGLTDRTFLLSEAMATFGT-QVIRRYSSVL---GNSLAIMP--HQFPDVMNFRRKDNN-SEYYLENIG------------ A7S0L2/181-317_442-461 RQSEAMADIIEHFKWAYVAAIAHDG-SYGQYGVRALEREAYDRKTFCIS-FVEFFTRSG---------YKGKVETIVRKLLLKPELKVIVFWSNYDQTDAFLAEATKQNLTDRTFLLSEAMATFGI-QILKKYSSVL---GGSLAILP--HDYRDIMNFRKEDDC-DGYCIKNVG------------ B3RUD6/167-301_432-442 QQARAIADLIYGFGWTYIATVTVDD-IYSRLFMDLIQRRL-RLKSICVA-KDLYFPQTN---------NTQRIQSIISQLADLSNVSAIILIAQEKEALSVLKEANNQGLTGKIWIGTESWSDSA--ELLKLSRDIV---GGLLGVVP--RSQPSIINLQFDENN---------------------- B3S610/166-300_433-453 YQVSALIDIIKHFDWNYISIIAIDD-SYGRQGVSEINKQT-RHNEICTA-VVEYISDPS---------DRSTISRILQRIELFPKAKAIILFTTEFDAVNIIQEAEKRNLTGLIFIGTDAWSDSL--KFTRLDPKVI---GGMLGVSL--DGKNTIVNLQPDNVDKNRMKFVKIG------------ A7S0D3/205-343_497-519 ---------VAYYGWSYVSVVATDE-DYGRLGIEAFKQEV-KSRNVCIS-VDELFHPNNNLPE-----TKASIKSIVTKLKNDKKATVVVLFCESPNALAVLEEAEQQGLHGKTWIGAEAWGDKS--TVLDFKNSTV---GGMLGVLP--WKGRIETFEEHMATSPHGHSFVTIGYWSWT-TRQLQL A7S0J8/156-290_435-455 YQAKAIADLLAAFQWAYVSVVASDD-AYGRAGMDALKEEL-KKRDICLA-IDAIFHHEM---------YKSELHQIITSLKSKPRAKVIVLWCQRPNAIGFLQVATELQLTQRTWIGTETWGDSY--LLESLSQDIV---GGLVGVVP--HLIKSIKSLQVDASKPAKMKFVEIG------------ B3S462/177-313_445-455 YQAQAIVDIVKYFGWDYIAVVSTND-QYGNQLRAKIVTLA-SEYQICIA-INAQFPSQF---------HDQIISDIVNRLVNNVKVKTIILICSEAEAKVLLKEAQYQNLTGRMWLGSDAWGNSP--VIARTYSDVV---IGMIGVTLLQSKQKDIFQLQLTKDS---------------------- B3RWY5/139-275_402-421 NQAKALVKLVKYFGWNYVALVAVTD-SYGDALASSFSAMA-STVGICIP-IHRIISTLD---------GKNQIRNIVQDIAKNDKVNVILLMVTLTEAKLFIEELYNQNVTGKTLVGCDAWIGD---KLLRIVNHIYFDQQGVIGLTF--SPNYSIANIQKHPTT-GRFYLRAVG------------ B3S157/187-322_446-466 QQARAIAQLIRYFNWTYVSTIAVDT-AYGRQGIQLFHEAA-AALGICTSPVSEIFSASN---------PKSELPRIIQKLKQQSNATVIVFYSDEYNAMLLLNEADKQNLVGRTWIASESWGDSS--YITRMPPGVI---GGMLGVVP--QTTSVVVNLQPDRQPFGRMKYKIVG------------ A0A369SLR2/220-354_483-494 FQGRAVTAVIHYFGWNYTAVLWEDD-DYGNSLVEEFQRSA-KEKNVCIS-KVILFPKRP---------TASQLQSIIKELRAL-KVTVVFIASNAKMAHEYFIQATIANFTGITYIAPISWSQSSS-IISEIDSDII---GGTIGLTL--GSSKNIVNLQPNGKN-V-------------------- A0A369SI03/215-349_480-490 QQARAIADLIYGFGWTYIATVTVDD-IYSRLFMDLIQRRL-RLKSICVA-KDLYFPQTN---------NTQRIQSIISQLADLSNVSAIILIAQEKEALSVLKEANNQGLTGKIWIGTESWSDSA--ELLKLSRDIV---GGLLGVVP--RSQPSIINLQFDENN---------------------- A0A369RPI5/204-338_471-491 YQVSALIDIIKHFDWNYISIIAIDD-SYGRQGVSEINKQT-RHNEICTA-VVEYISDPS---------DRSTISRILQRIELFPKAKAIILFTTEFDAVNIIQEAEKRNLTGLIFIGTDAWSDSL--KFTRLDPKVI---GGMLGVSL--DGKNTIVNLQPDNVDKNRMKFVKIG------------ A0A369S5E3/233-369_501-511 YQAQAIVDIVKYFGWDYIAVVSTND-QYGNQLRAKIVTLA-SEYQICIA-INAQFPSQF---------HDQIISDIVNRLVNNVKVKTIILICSEAEAKVLLKEAQYQNLTGRMWLGSDAWGNSP--VIARTYSDVV---IGMIGVTLLQSKQKDIFQLQLAKDS---------------------- A0A369SCE0/206-342_469-488 NQAKALVKLVKYFGWNYVALVAVTD-SYGDALASSFSAMA-STVGICIP-IHRIISTLD---------GKNQIRNIVQDIAKNDKVNVILLMVTLTEAKLFIEELYNQNVTGKTLVGCDAWIGD---KLLRIVNHIYFDQQGVIGLTF--SPNYSIANIQKHPTT-GRFYLRAVG------------ A0A369SRG8/208-343_467-487 QQARAIAQLIRYFNWTYVSTIAVDT-AYGRQGIQLFHEAA-AALGICTSPVSEIFSASN---------PKSELPRIIQKLKQQSNATVIVFYSDEYNAMLLLNEADKQNLVGRTWIASESWGDSS--YITRMPPGVI---GGMLGVVP--QTTSVVVNLQPDRQPFGRMKYKIVG------------ #=GC scorecons 2744744457358484766465374049843453354435033345965033446433300000000034346338634643224546766343323733563773365656565645655444200243433335400047367535003323343546322220111111122000000000000 #=GC scorecons_70 _*__*____*__*_*_***____*___**_________________**______*____________________**__*_______**________*___*_**__________*_________________________*__*__________________________________________ #=GC scorecons_80 _*__________*_*_*__________**_________________*____________________________*____________*____________________________________________________*__*__________________________________________ #=GC scorecons_90 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