# STOCKHOLM 1.0 #=GF ID 3.40.50.150/FF/000268 #=GF DE Histidine protein methyltransferase 1 homolog #=GF AC 3.40.50.150/FF/000268 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 62.590 #=GS O95568/144-355 AC O95568 #=GS O95568/144-355 OS Homo sapiens #=GS O95568/144-355 DE Histidine protein methyltransferase 1 homolog #=GS O95568/144-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS O95568/144-355 DR GO; GO:0005515; GO:0031072; GO:0032991; #=GS Q9VQK8/90-297 AC Q9VQK8 #=GS Q9VQK8/90-297 OS Drosophila melanogaster #=GS Q9VQK8/90-297 DE FI02048p #=GS Q9VQK8/90-297 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; #=GS Q9VQK8/90-297 DR GO; GO:0005634; GO:0005737; GO:0008757; #=GS Q9CZ09/129-344 AC Q9CZ09 #=GS Q9CZ09/129-344 OS Mus musculus #=GS Q9CZ09/129-344 DE Histidine protein methyltransferase 1 homolog #=GS Q9CZ09/129-344 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Mus; Mus; Mus musculus; #=GS Q9CZ09/129-344 DR GO; GO:0031072; GO:0032991; #=GS A0A024R8Y7/144-355 AC A0A024R8Y7 #=GS A0A024R8Y7/144-355 OS Homo sapiens #=GS A0A024R8Y7/144-355 DE Chromosome 1 open reading frame 156, isoform CRA_a #=GS A0A024R8Y7/144-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS F7FUD2/144-356 AC F7FUD2 #=GS F7FUD2/144-356 OS Callithrix jacchus #=GS F7FUD2/144-356 DE Uncharacterized protein #=GS F7FUD2/144-356 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix; Callithrix jacchus; #=GS Q4KM84/128-344 AC Q4KM84 #=GS Q4KM84/128-344 OS Rattus norvegicus #=GS Q4KM84/128-344 DE Histidine protein methyltransferase 1 homolog #=GS Q4KM84/128-344 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Rattus; Rattus norvegicus; #=GS A0A096N363/143-356 AC A0A096N363 #=GS A0A096N363/143-356 OS Papio anubis #=GS A0A096N363/143-356 DE Uncharacterized protein #=GS A0A096N363/143-356 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Papio; Papio anubis; #=GS G1RYG2/140-355 AC G1RYG2 #=GS G1RYG2/140-355 OS Nomascus leucogenys #=GS G1RYG2/140-355 DE Uncharacterized protein #=GS G1RYG2/140-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hylobatidae; Nomascus; Nomascus leucogenys; #=GS A0A2J8SAZ7/144-355 AC A0A2J8SAZ7 #=GS A0A2J8SAZ7/144-355 OS Pongo abelii #=GS A0A2J8SAZ7/144-355 DE METTL18 isoform 1 #=GS A0A2J8SAZ7/144-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Ponginae; Pongo; Pongo abelii; #=GS A0A2R8ZP28/144-355 AC A0A2R8ZP28 #=GS A0A2R8ZP28/144-355 OS Pan paniscus #=GS A0A2R8ZP28/144-355 DE Uncharacterized protein #=GS A0A2R8ZP28/144-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan paniscus; #=GS G8F371/143-355 AC G8F371 #=GS G8F371/143-355 OS Macaca fascicularis #=GS G8F371/143-355 DE Uncharacterized protein #=GS G8F371/143-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca fascicularis; #=GS A0A0D9SA72/142-355 AC A0A0D9SA72 #=GS A0A0D9SA72/142-355 OS Chlorocebus sabaeus #=GS A0A0D9SA72/142-355 DE Uncharacterized protein #=GS A0A0D9SA72/142-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Chlorocebus; Chlorocebus sabaeus; #=GS G3RIK4/144-355 AC G3RIK4 #=GS G3RIK4/144-355 OS Gorilla gorilla gorilla #=GS G3RIK4/144-355 DE Methyltransferase like 18 #=GS G3RIK4/144-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Gorilla; Gorilla gorilla; Gorilla gorilla gorilla; #=GS A0A2K5XML1/143-355 AC A0A2K5XML1 #=GS A0A2K5XML1/143-355 OS Mandrillus leucophaeus #=GS A0A2K5XML1/143-355 DE Uncharacterized protein #=GS A0A2K5XML1/143-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Mandrillus; Mandrillus leucophaeus; #=GS H2Q0K6/144-355 AC H2Q0K6 #=GS H2Q0K6/144-355 OS Pan troglodytes #=GS H2Q0K6/144-355 DE METTL18 isoform 1 #=GS H2Q0K6/144-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan troglodytes; #=GS F7CK58/143-355 AC F7CK58 #=GS F7CK58/143-355 OS Macaca mulatta #=GS F7CK58/143-355 DE Histidine protein methyltransferase 1 homolog #=GS F7CK58/143-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; #=GS A0A2K6B0I1/143-355 AC A0A2K6B0I1 #=GS A0A2K6B0I1/143-355 OS Macaca nemestrina #=GS A0A2K6B0I1/143-355 DE Uncharacterized protein #=GS A0A2K6B0I1/143-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca nemestrina; #=GS I7GIV6/33-245 AC I7GIV6 #=GS I7GIV6/33-245 OS Macaca fascicularis #=GS I7GIV6/33-245 DE Macaca fascicularis brain cDNA clone: QflA-22953, similar to human hypothetical protein MGC9084 (MGC9084), mRNA, RefSeq: NM_033418.1 #=GS I7GIV6/33-245 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca fascicularis; #=GS B4I2U6/90-298 AC B4I2U6 #=GS B4I2U6/90-298 OS Drosophila sechellia #=GS B4I2U6/90-298 DE GM18388 #=GS B4I2U6/90-298 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila sechellia; #=GS B4NXC7/90-298 AC B4NXC7 #=GS B4NXC7/90-298 OS Drosophila yakuba #=GS B4NXC7/90-298 DE Uncharacterized protein #=GS B4NXC7/90-298 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila yakuba; #=GS B3NAP7/92-299 AC B3NAP7 #=GS B3NAP7/92-299 OS Drosophila erecta #=GS B3NAP7/92-299 DE Uncharacterized protein #=GS B3NAP7/92-299 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila erecta; #=GS B4Q918/90-296 AC B4Q918 #=GS B4Q918/90-296 OS Drosophila simulans #=GS B4Q918/90-296 DE GD23200 #=GS B4Q918/90-296 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila simulans; #=GF SQ 22 O95568/144-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQ-LYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKII----- Q9VQK8/90-297 -EQSHLVNLDLRKSEENHSDLISGVYEGGAKIWECTEDLLLYLSEKYEDSFWKEKRVLDLGCGCGLLGIYAMKHGAR-VDFQDYNKDVLEYITYPNILLNL---DDSLSEDE-KLKFLDNSTT--------LYSGDWSHFAELSRDVA----KYDLILTSETIYNIANQQKLLDTFAGRLKSDGVILVAAKSHYFGVGGGLEQFSENIRLGNVFQSESVWQADENL- Q9CZ09/129-344 -EKFPGENI-VSKSFSSHSDLIPGVYEGGLKIWECTFDLLTYFTK--AKVKFAGQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIDEVTLPNVVANVPLQDDSNGKNEPDGKRQRKSEVGREICKCRLFSGEWAEFCKLVL-REKLFVKYDLILTSETIYNPDYYSTLHETFLRLLSRSGRVLLASKAHYFGVGGGVHLFQKFVEEKGVFETRTLEV------ A0A024R8Y7/144-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQ-LYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKII----- F7FUD2/144-356 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTN--AKVKFAGKKVLDLGCGSGLLGMTAFKRGAKEVHFQDYNSMVIDEVTLPNVVANSILEDEENDVNEPDVKRCRTSKVIQEPYQCRFFSGEWSDFCKLVLSSENLFVKYDLILTSETIYNPDYYSNLHQTFLGLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFETRILKII----- Q4KM84/128-344 KEKFPGENI-VSQSFSSHSDLIPGVYEGGLKIWECTFDLMTYFTK--AKVKFAGQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIDEVTLPNVVANVPLQGDSNGINEPAGKRQRKSEVAQETCKCRLFSGEWAEFCKLVL-SEKLFVKYDLILTSETIYNPDYYSTLHETLLRLLSRNGRVLLASKAHYFGVGGGVHLFQKFVEEKGVFETRTLEV------ A0A096N363/143-356 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTLANVVANSTLEDEENDVNEPDLKRCRKPKVTQELYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFIEERDVFKTRILKITD---- G1RYG2/140-355 ---FHGENI-VAKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQELYKCRFFSGEWSEFYKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKII----- A0A2J8SAZ7/144-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQ-LYKCRFFSGEWSEFCKLVLSSEKLFVKYDLVLTSETIYNPDYYSNLHETFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFNTRILKII----- A0A2R8ZP28/144-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQ-LYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKII----- G8F371/143-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTLANVVANSTLEDEENDVNKPDLKRCKKPKVTQELYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFIEERDVFKTRILKII----- A0A0D9SA72/142-355 -----GENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTLANVVANSNLEDEENDVNEPDLKRCRKPKVTQELYKCRFFSGEWSEFCKLILSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFIEERDVFKTRILKII----- G3RIK4/144-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAHFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQ-LYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRILLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKII----- A0A2K5XML1/143-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTLANVVANSTLEDEENDVNEPDLKRCKKPKVTQELYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFIEERDVFKTRILKII----- H2Q0K6/144-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQ-LYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKII----- F7CK58/143-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTLANVVANSTLEDEENDVNKPDLKRCKKPKVTQELYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFIEERDVFKTRILKII----- A0A2K6B0I1/143-355 ------ENI-VSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTFANVVANSTLEDEENDVNKPDLKRCKKPKVTQELYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFIEERDVFKTRILKII----- I7GIV6/33-245 ------ENI-VSKRFSSHSDLITGVYEGGLKIWECTFDLLAYFTK--AKVKFAGKKVLDLGCGSGLLGITAFKGGAKEIHFQDYNSMVIDEVTLANVVANSTLEDEENDVNKPDLKRCKKPKVTQELYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFIEERDVFKTRILKII----- B4I2U6/90-298 -EQSHLVNLDLRKSEEKHSDLISGVYEGGAKIWECTEDLLLYLSEKYEDSFWKEKRVLDLGCGCGLLGIYAMKHGAR-VDFQDYNKDVLEYITYPNILLNV---DDSLSEDE-KLKFLDNSTT--------LYSGDWSHFAELTRDVE----KYDLILTSETIYNIANQQKLLDTFAGRLKSDGVILVAAKSHYFGVGGGLEQFSENIRLGNAFQSESVWQADENLK B4NXC7/90-298 -EQSQLVNLDLRKSEEKHSDLISGVYEGGAKIWECTEDLLLYLSEKYEDSFWKDKRVLDLGCGCGLLGVYAMKHGAQ-VDFQDYNKDVLEYITYPNIVLNL---EDSLSEDE-KLKFLDKSTT--------LYSGDWTNFAELSRNEE----KYDLILTSETIYNIENQQKLLDTFAGRLKSEGVVLVAAKSHYFGVGGGLEQFSERIRLGNVFQSESVWQAEENLK B3NAP7/92-299 --QSHLVNLDLRKSEEKHSDLISGVYEGGAKIWECTEDLLLYLSEKYENSFWKEKSVLDLGCGCGLLGIYAMKHGAL-VDFQDYNKDVLEYITYPNIMLNL---DDSLSEDE-KLKFLDKSTT--------LYSGDWTHFAELTRDEE----KYDVILTSETIYNINNQQKLLETFAGRLKSEGVVLVAAKSHYFGVGGGLEQFSESIRLGNVFQSESVWQAEENLK B4Q918/90-296 -EQSHLVNLDLRKSEEKHSDLISGVYEGGAKIWECTEDLLLYLSEKYEDSFWKEKRVLDLGCGCGLLGIYAMKHGAR-VDFQDYNKDVLEYITYPNILLNV---DDSLSEDE-KLKFLDNSTT--------LYSGDWSHFAELTRDVE----KYDLILTSETIYNIANQQKLLDTFAGRLKSDGVILVAAKSHYFGVGGGLEQFSEIIRLGNVFQSESVWQADEN-- #=GC scorecons 01111159616588455999995999999599999949985866511555455586999999969999849595975275999995496747957976594222775454672559445665522122222679979659569544472222999889999999955555595598554955594796969699999999655956475455895655644411100 #=GC scorecons_70 _______**_*_**___*****_******_******_***_**___________*********_*****_*_*_**__*_*****__***_**_****_*____**____**___*___*___________*******_*__*____*____*************______*__**___*___*_****_*_*********__*___*____**____*________ #=GC scorecons_80 _______*____**___*****_******_******_***_*____________*_*******_*****_*_*_**____*****__*____*__*___*____*______*___*________________***_*__*__*____*____*************______*__**___*___*_**_*_*_********___*___*____**_____________ #=GC scorecons_90 _______*____**___*****_******_******_***_*____________*_*******_*****_*_*_*_____*****__*____*__*___*_______________*_________________**_*__*__*_________*************______*__**___*___*__*_*_*_********___*________**_____________ //