The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
TPP-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Pyruvate decarboxylase isozyme

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
15 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P26263 (/IDA)
(5 more)
Branched-chain-2-oxoacid decarboxylase activity GO:0047433
Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2).
9 P06169 (/IMP) P06169 (/IMP) P06169 (/IMP) P06169 (/IMP) P06169 (/IMP) P16467 (/IMP) P16467 (/IMP) P16467 (/IMP) P16467 (/IMP)
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
4 P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI)
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
4 P26263 (/IMP) P26263 (/IMP) P26263 (/IMP) P26263 (/IMP)
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
1 Q09737 (/ISO)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aromatic amino acid family catabolic process to alcohol via Ehrlich pathway GO:0000949
The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
13 P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P26263 (/IGI)
(3 more)
L-phenylalanine catabolic process GO:0006559
The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
13 P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P26263 (/IGI)
(3 more)
Tryptophan catabolic process GO:0006569
The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
13 P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P26263 (/IGI)
(3 more)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
11 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) Q6FJA3 (/IDA)
(1 more)
Glycolytic fermentation to ethanol GO:0019655
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose.
9 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA)
Ethanol metabolic process GO:0006067
The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
4 P26263 (/IMP) P26263 (/IMP) P26263 (/IMP) P26263 (/IMP)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
4 P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI)
Glycolytic fermentation to ethanol GO:0019655
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose.
4 P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
1 Q09737 (/ISO)
Glycolytic fermentation to ethanol GO:0019655
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose.
1 Q09737 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P16467 (/HDA) P16467 (/HDA) P16467 (/HDA) P16467 (/HDA) P26263 (/HDA)
(3 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P16467 (/HDA) P16467 (/HDA) P16467 (/HDA) P16467 (/HDA) Q09737 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) Q6FJA3 (/IDA) Q6FJA3 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 G8BHF2 (/IDA) P83779 (/IDA) P83779 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P83779 (/IDA) P83779 (/IDA)
Yeast-form cell wall GO:0030445
The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.
2 P83779 (/IDA) P83779 (/IDA)
Hyphal cell wall GO:0030446
The cell wall surrounding a fungal hypha.
2 P83779 (/IDA) P83779 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
2 P83779 (/IDA) P83779 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q09737 (/HDA)
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