# STOCKHOLM 1.0
#=GF ID 3.40.430.10/FF/000009
#=GF DE Dihydrofolate reductase
#=GF AC 3.40.430.10/FF/000009
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 85.579
#=GS 3ix9B00/22-190    AC Q54801
#=GS 3ix9B00/22-190    OS Streptococcus pneumoniae TIGR4
#=GS 3ix9B00/22-190    DE Dihydrofolate reductase
#=GS 3ix9B00/22-190    DR CATH; 3ix9; B:2-167; 
#=GS 3ix9B00/22-190    DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS 3ix9B00/22-190    DR GO; GO:0005515; 
#=GS 3ix9B00/22-190    DR EC; 1.5.1.3; 
#=GS O85255/2-168      AC O85255
#=GS O85255/2-168      OS Streptococcus pneumoniae
#=GS O85255/2-168      DE Dihydrofolate reductase
#=GS O85255/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS O85255/2-168      DR GO; GO:0004146; 
#=GS 3ix9A00/22-190    AC Q54801
#=GS 3ix9A00/22-190    OS Streptococcus pneumoniae TIGR4
#=GS 3ix9A00/22-190    DE Dihydrofolate reductase
#=GS 3ix9A00/22-190    DR CATH; 3ix9; A:2-167; 
#=GS 3ix9A00/22-190    DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS 3ix9A00/22-190    DR GO; GO:0005515; 
#=GS 3ix9A00/22-190    DR EC; 1.5.1.3; 
#=GS 3tqbA00/1-160     AC Q83AB2
#=GS 3tqbA00/1-160     OS Coxiella burnetii RSA 493
#=GS 3tqbA00/1-160     DE Dihydrofolate reductase
#=GS 3tqbA00/1-160     DR CATH; 3tqb; A:1-160; 
#=GS 3tqbA00/1-160     DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae; Coxiella; Coxiella burnetii; 
#=GS 3tqaA00/1-160     AC Q83AB2
#=GS 3tqaA00/1-160     OS Coxiella burnetii RSA 493
#=GS 3tqaA00/1-160     DE Dihydrofolate reductase
#=GS 3tqaA00/1-160     DR CATH; 3tqa; A:1-160; 
#=GS 3tqaA00/1-160     DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae; Coxiella; Coxiella burnetii; 
#=GS 3tq9A00/1-160     AC Q83AB2
#=GS 3tq9A00/1-160     OS Coxiella burnetii RSA 493
#=GS 3tq9A00/1-160     DE Dihydrofolate reductase
#=GS 3tq9A00/1-160     DR CATH; 3tq9; A:1-160; 
#=GS 3tq9A00/1-160     DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae; Coxiella; Coxiella burnetii; 
#=GS 3tq8A00/1-178     AC Q83AB2
#=GS 3tq8A00/1-178     OS Coxiella burnetii RSA 493
#=GS 3tq8A00/1-178     DE Dihydrofolate reductase
#=GS 3tq8A00/1-178     DR CATH; 3tq8; A:1-173; 
#=GS 3tq8A00/1-178     DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae; Coxiella; Coxiella burnetii; 
#=GS Q54801/2-168      AC Q54801
#=GS Q54801/2-168      OS Streptococcus pneumoniae TIGR4
#=GS Q54801/2-168      DE Dihydrofolate reductase
#=GS Q54801/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS Q54801/2-168      DR GO; GO:0005515; 
#=GS Q54801/2-168      DR EC; 1.5.1.3; 
#=GS Q7NHQ9/1-155      AC Q7NHQ9
#=GS Q7NHQ9/1-155      OS Gloeobacter violaceus PCC 7421
#=GS Q7NHQ9/1-155      DE Dihydrofolate reductase
#=GS Q7NHQ9/1-155      DR ORG; Bacteria; Cyanobacteria; Gloeobacteria; Gloeobacterales; Gloeobacteraceae; Gloeobacter; Gloeobacter violaceus; 
#=GS Q83AB2/1-161      AC Q83AB2
#=GS Q83AB2/1-161      OS Coxiella burnetii RSA 493
#=GS Q83AB2/1-161      DE Dihydrofolate reductase
#=GS Q83AB2/1-161      DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae; Coxiella; Coxiella burnetii; 
#=GS B7VPW7/27-183     AC B7VPW7
#=GS B7VPW7/27-183     OS Vibrio tasmaniensis LGP32
#=GS B7VPW7/27-183     DE Dihydrofolate reductase type I (Trimethoprim resistance)
#=GS B7VPW7/27-183     DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; Vibrio tasmaniensis; 
#=GS B7VPW7/27-183     DR GO; GO:0004146; 
#=GS A0A0B7L9Q4/2-168  AC A0A0B7L9Q4
#=GS A0A0B7L9Q4/2-168  OS Streptococcus pneumoniae
#=GS A0A0B7L9Q4/2-168  DE Dihydrofolate reductase
#=GS A0A0B7L9Q4/2-168  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A0A0B7L9Q4/2-168  DR EC; 1.5.1.3; 
#=GS M5K663/2-168      AC M5K663
#=GS M5K663/2-168      OS Streptococcus pneumoniae PCS8106
#=GS M5K663/2-168      DE Dihydrofolate reductase
#=GS M5K663/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS M5K663/2-168      DR EC; 1.5.1.3; 
#=GS M5JWL8/2-168      AC M5JWL8
#=GS M5JWL8/2-168      OS Streptococcus pneumoniae PCS8203
#=GS M5JWL8/2-168      DE Dihydrofolate reductase
#=GS M5JWL8/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS M5JWL8/2-168      DR EC; 1.5.1.3; 
#=GS A0A0U0GZ11/2-168  AC A0A0U0GZ11
#=GS A0A0U0GZ11/2-168  OS Streptococcus pneumoniae
#=GS A0A0U0GZ11/2-168  DE Dihydrofolate reductase
#=GS A0A0U0GZ11/2-168  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A5M941/2-168      AC A5M941
#=GS A5M941/2-168      OS Streptococcus pneumoniae SP14-BS69
#=GS A5M941/2-168      DE Dihydrofolate reductase
#=GS A5M941/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS G6JC27/2-168      AC G6JC27
#=GS G6JC27/2-168      OS Streptococcus pneumoniae GA47502
#=GS G6JC27/2-168      DE Dihydrofolate reductase
#=GS G6JC27/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS J1NV80/2-168      AC J1NV80
#=GS J1NV80/2-168      OS Streptococcus pneumoniae 2070335
#=GS J1NV80/2-168      DE Dihydrofolate reductase
#=GS J1NV80/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS Q93V28/2-168      AC Q93V28
#=GS Q93V28/2-168      OS Streptococcus pneumoniae
#=GS Q93V28/2-168      DE Dihydrofolate reductase
#=GS Q93V28/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS Q7CRB0/2-168      AC Q7CRB0
#=GS Q7CRB0/2-168      OS Streptococcus pneumoniae R6
#=GS Q7CRB0/2-168      DE Dihydrofolate reductase
#=GS Q7CRB0/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS Q9R930/2-168      AC Q9R930
#=GS Q9R930/2-168      OS Streptococcus pneumoniae
#=GS Q9R930/2-168      DE Dihydrofolate reductase
#=GS Q9R930/2-168      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A0A0H2ZQQ1/2-168  AC A0A0H2ZQQ1
#=GS A0A0H2ZQQ1/2-168  OS Streptococcus pneumoniae D39
#=GS A0A0H2ZQQ1/2-168  DE Dihydrofolate reductase
#=GS A0A0H2ZQQ1/2-168  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A9KH09/1-161      AC A9KH09
#=GS A9KH09/1-161      OS Coxiella burnetii Dugway 5J108-111
#=GS A9KH09/1-161      DE Dihydrofolate reductase
#=GS A9KH09/1-161      DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae; Coxiella; Coxiella burnetii; 
#=GF SQ 23
3ix9B00/22-190            TKKIVAIWAQDEEGVIGKDNRLPWYLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFHDVQSVLDWYSAQEKNLYIVGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPAEFDLSLFETVSSKFYTKDEKNPYDFTIQYRKRKEVL-------------E
O85255/2-168              TKKIVAIWAQDEEGVIGKDNRLPWYLPAELQHFKETTLNHAILMGRVTFDGI----GRRLLPQRETLILTRNSEEKID-GVTTFQDVQSVLDWYQAQEKNLYILGGKQIFQAFEPYLDEVIVTQIHARVEGDTYFPEEFDLSLFETVSSKSYTKDEKNPYDFTIQYRKRKEV---------------
3ix9A00/22-190            TKKIVAIWAQDEEGVIGKDNRLPWYLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFHDVQSVLDWYSAQEKNLYIVGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPAEFDLSLFETVSSKFYTKDEKNPYDFTIQYRKRKEVL-------------E
3tqbA00/1-160             M-IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSI----GKP-LPHRRNIVITQQKNLIIE-GCDIFYSLDDALSAL-TKEPEVIIIGGARIFKEALPKADKMILTIINHSFEGDVYFPEWNDK-EWKITSQIKHERDEKNPYPFQFLELRR------------------
3tqaA00/1-160             M-IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSI----GKP-LPHRRNIVITQQKNLIIE-GCDIFYSLDDALSAL-TKEPEVIIIGGARIFKEALPKADKMILTIINHSFEGDVYFPEWNDK-EWKITSQIKHERDEKNPYPFQFLELRR------------------
3tq9A00/1-160             M-IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSI----GKP-LPHRRNIVITQQKNLIIE-GCDIFYSLDDALSAL-TKEPEVIIIGGARIFKEALPKADKMILTIINHSFEGDVYFPEWNDK-EWKITSQIKHERDEKNPYPFQFLELRR------------------
3tq8A00/1-178             M-IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSI----GKP-LPHRRNIVITQQKNLIIE-GCDIFYSLDDALSAL-TKEPEVIIIGGARIFKEALPKADKMILTIINHSFEGDVYFPEWNDK-EWKITSQIKHERDEKNPYPFQFLELRRLENLYFQGHHHHHHHHHH
Q54801/2-168              TKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
Q7NHQ9/1-155              M-ELIAVVAMDSRRLIGRGDGLPWHCPEDLSAFKALTWGQPLLMGRRTFESILARRGKP-LPEREHYVLTARRGPSFP-TVRYICSPDQALA---LPVERLFVIGGASVYAQTADQLDTLYLSLIPGLHTGDVFLPDLGNRWAVEIIEK--------------FQTFKRWRLL------------RS
Q83AB2/1-161              M-IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSI----GKP-LPHRRNIVITQQKNLIIE-GCDIFYSLDDALSAL-TKEPEVIIIGGARIFKEALPKADKMILTIINHSFEGDVYFPEWNDK-EWKITSQIKHERDEKNPYPFQFLELRRL-----------------
B7VPW7/27-183             L-KLSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESM----GK--LPNRKYAVISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKHISGDIFFPELPRDLTLVFEQR------FSSNIDYTYQIWQKG-----------------
A0A0B7L9Q4/2-168          TKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
M5K663/2-168              TKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
M5JWL8/2-168              TKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
A0A0U0GZ11/2-168          TKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFGPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
A5M941/2-168              TKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFGPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
G6JC27/2-168              TKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFGPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
J1NV80/2-168              TKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQDQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
Q93V28/2-168              TKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQDQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
Q7CRB0/2-168              TKKIVAIWAQDEEGLIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQDQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
Q9R930/2-168              TKKIVAIWAQDEEGLIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQDQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
A0A0H2ZQQ1/2-168          TKKIVAIWAQDEEGLIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGM----GRRLLPKRETLILTRNPEEKID-GVATFQDVQSVLDWYQDQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV---------------
A9KH09/1-161              M-IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSI----GKP-LPHRRNIVITQQKNLIIE-GCDIFYSLDDALSAL-TKEPEVIIIGGARIFKEALPKADKMILTIINHSFEGDVYFPEWNDK-EWKITSQIKHERDEKNPYPFQFLELRRL-----------------
#=GC scorecons            5147557494755569965658997677774699459755576899499766000097419959545768554534660754474555569534144645557799558854436459556674954446995889733742345556432434666666464553468222000000000000000
#=GC scorecons_70         ___*__*_*_*___****_*_*********_***__**___*****_***_*____**__**_*___***______*__*___*______*______*____****__**____*__*__*_*_*____***_****__*_______*________****_*_____**__________________
#=GC scorecons_80         ___*__*_*_*____**____***__*__*__**__*____*_***_***______*___**_*_____*_____________*______*___________*_**__**_______*____*_*_____**_****_______________________________*__________________
#=GC scorecons_90         ________*______**____***________**__*______***_**_______*___**_*__________________________*_____________**__*________*______*_____**__**________________________________*__________________
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