# STOCKHOLM 1.0
#=GF ID 3.40.1190.10/FF/000016
#=GF DE Folylpolyglutamate synthase
#=GF AC 3.40.1190.10/FF/000016
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 89.880
#=GS X2JDF2/55-348      AC X2JDF2
#=GS X2JDF2/55-348      OS Drosophila melanogaster
#=GS X2JDF2/55-348      DE Folylpolyglutamate synthase
#=GS X2JDF2/55-348      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; 
#=GS X2JDF2/55-348      DR GO; GO:0004326; GO:0005737; GO:0005739; GO:0046901; 
#=GS Q38AL2/45-317      AC Q38AL2
#=GS Q38AL2/45-317      OS Trypanosoma brucei brucei TREU927
#=GS Q38AL2/45-317      DE Folylpolyglutamate-dihydrofolate synthetase, putative
#=GS Q38AL2/45-317      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; 
#=GS Q38AL2/45-317      DR GO; GO:0005739; 
#=GS Q9VYL1/84-377      AC Q9VYL1
#=GS Q9VYL1/84-377      OS Drosophila melanogaster
#=GS Q9VYL1/84-377      DE Folylpolyglutamate synthase
#=GS Q9VYL1/84-377      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; 
#=GS Q9VYL1/84-377      DR GO; GO:0004326; GO:0005737; GO:0005739; GO:0046901; 
#=GS Q8MRU3/84-377      AC Q8MRU3
#=GS Q8MRU3/84-377      OS Drosophila melanogaster
#=GS Q8MRU3/84-377      DE Folylpolyglutamate synthase
#=GS Q8MRU3/84-377      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; 
#=GS Q8MRU3/84-377      DR GO; GO:0004326; GO:0005737; GO:0005739; GO:0046901; 
#=GS E3L2Y2/31-319      AC E3L2Y2
#=GS E3L2Y2/31-319      OS Puccinia graminis f. sp. tritici CRL 75-36-700-3
#=GS E3L2Y2/31-319      DE Folylpolyglutamate synthase
#=GS E3L2Y2/31-319      DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia; Puccinia graminis; 
#=GS A9V8L2/2-289       AC A9V8L2
#=GS A9V8L2/2-289       OS Monosiga brevicollis
#=GS A9V8L2/2-289       DE Folylpolyglutamate synthase
#=GS A9V8L2/2-289       DR ORG; Eukaryota; Choanoflagellida; Salpingoecidae; Monosiga; Monosiga brevicollis; 
#=GS A4ICG7/56-350      AC A4ICG7
#=GS A4ICG7/56-350      OS Leishmania infantum
#=GS A4ICG7/56-350      DE Folylpolyglutamate synthetase
#=GS A4ICG7/56-350      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; 
#=GS A0A1G4IJA9/45-317  AC A0A1G4IJA9
#=GS A0A1G4IJA9/45-317  OS Trypanosoma equiperdum
#=GS A0A1G4IJA9/45-317  DE Folylpolyglutamate synthase, putative
#=GS A0A1G4IJA9/45-317  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma equiperdum; 
#=GS Q4Q1G0/52-346      AC Q4Q1G0
#=GS Q4Q1G0/52-346      OS Leishmania major
#=GS Q4Q1G0/52-346      DE Folylpolyglutamate synthetase
#=GS Q4Q1G0/52-346      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania major species complex; Leishmania major; 
#=GS E9AT38/52-346      AC E9AT38
#=GS E9AT38/52-346      OS Leishmania mexicana MHOM/GT/2001/U1103
#=GS E9AT38/52-346      DE Folylpolyglutamate synthetase
#=GS E9AT38/52-346      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania mexicana; 
#=GS A0A3Q8IJ59/56-350  AC A0A3Q8IJ59
#=GS A0A3Q8IJ59/56-350  OS Leishmania donovani
#=GS A0A3Q8IJ59/56-350  DE Folylpolyglutamate synthetase
#=GS A0A3Q8IJ59/56-350  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; 
#=GS A0A180GUY9/32-324  AC A0A180GUY9
#=GS A0A180GUY9/32-324  OS Puccinia triticina 1-1 BBBD Race 1
#=GS A0A180GUY9/32-324  DE Folylpolyglutamate synthase
#=GS A0A180GUY9/32-324  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia; Puccinia triticina; 
#=GS E9BTY3/56-350      AC E9BTY3
#=GS E9BTY3/56-350      OS Leishmania donovani BPK282A1
#=GS E9BTY3/56-350      DE Folylpolyglutamate synthetase
#=GS E9BTY3/56-350      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; 
#=GS B4IGH5/87-375      AC B4IGH5
#=GS B4IGH5/87-375      OS Drosophila sechellia
#=GS B4IGH5/87-375      DE Folylpolyglutamate synthase
#=GS B4IGH5/87-375      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila sechellia; 
#=GS B4NUC1/87-375      AC B4NUC1
#=GS B4NUC1/87-375      OS Drosophila simulans
#=GS B4NUC1/87-375      DE Folylpolyglutamate synthase
#=GS B4NUC1/87-375      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila simulans; 
#=GF SQ 15
X2JDF2/55-348              -SDNNNKDTNAAFELAIKQLNSLQSND---AAIRNSMSNSRVDTKADTIKYLERSGLPLETVEQLSFIHVAGTKGKGSTCALTESLLRHQ--GFRTGFFSSPHILFTNERIRIDGQLLSKDKFTEQFWKVYNRLWDLREHDH----DM-----PAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTNIVRNVRTVGITSLGLEHTELLGRTLPEIAWQKAGIIKTGSHVFT--HVTQPECLEVIRQRTKEHSATLY-EVPPTEDYFRSKAYAPIWQTFSNL-IRLNGSLAIQLAQDWLSQSG-----KQQHTPNE
Q38AL2/45-317              -----PTYRNRTLA------------------------NTSGKSAELVGLLVERLNMR-RCLDTLRFVHVAGTKGKGTTASYTAALLEAY--GLKVGLFTSPHVKDVRERIMVNNEVLPMDTFVHYFFQVVDCFVELAGADKEVTWDLPAP--CSFFCLMFLVSLVAFAGESVDVAVVEVGIGGSRDPTNIIIPE-ASVITALGIDHTEILGDTVEEIALQKAGIMKPGVVCYAAPQGDHPSTRRVLKDYAEGVDSPLV-----FADDVAVPTDGWPCLSIGGEHAVENSRLALLAARSVMGIPLTQPLDDVE-----
Q9VYL1/84-377              SSDNNNKDTNAAFELAIKQLNSLQSND---AAIRNSMSNSRVDTKADTIKYLERSGLPLETVEQLSFIHVAGTKGKGSTCALTESLLRHQ--GFRTGFFSSPHILFTNERIRIDGQLLSKDKFTEQFWKVYNRLWDLREHDH----DM-----PAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTNIVRNVRTVGITSLGLEHTELLGRTLPEIAWQKAGIIKTGSHVFT--HVTQPECLEVIRQRTKEHSATLY-EVPPTEDYFRSKAYAPIWQTFSNL-IRLNGSLAIQLAQDWLSQSG-----KQQHTPN-
Q8MRU3/84-377              SSDNNNKDTNAAFELAIKQLNSLQSND---AAIRNSMSNSRVDTKADTIKYLERSGLPLETVEQLSFIHVAGTKGKGSTCALTESLLRHQ--GYRTGFFSSPHILFTNERIRIDGQLLSKDKFTEQFWKVYSRLWDLREHDH----DM-----PAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTNIVRNVRTVGITSLGLEHTELLGRTLPEIAWQKAGIIKTGSHVFT--HVTQPECLEVIRQRTKEHSATLY-EVPPTEDYFRSKAYAPIWQTFSNL-IRLNGSLAIQLAQDWLSQSG-----KQQHTPN-
E3L2Y2/31-319              -----------GYEEAIVALNSLQSNASVLAAIQAAGPQPSERVFGQTNYYLRRLGYKPKDLNILNAIHISGTKGKGSTAAFCSSLLNTINPSAKVGLFTSPHLVAVRERIRINGKPISEEMFSKYFWELWERFEDGNGEPARP--DLPIR--PAYFRYLTYMAYHAFIAERVDATVFEVGVGGLLDPTNLIPSPIVTGVSSLGIDHVNVLGHSIAEIAGHKGGIFKPGVPALTV-QQQYPETINVLRARALELKSS------SFTIIPRRPDLDQLKIGLAGSHQKHNASFAIALVNTFLGSPR-LPHSYF------
A9V8L2/2-289               ---------SRSYQEAVEALNTFH-NAAELEKQRKSGGRDLTRSLPETRDYMRRLNITNEDLARMRIIHVAGSKGKGSTAAMCDALLRQQ--GFSTGLFTSPHLIEVRERIRVNGAPLSRAEFASTFWELYDALDATPPAD-----DILNF--PTYFRATFLMALLAFKRLKLDAIILEVGIGGLYDATNVVLEPWVCGITRLGLEHTSILGNTLTEIAHQKAGIMKENVPCFS--QPQEPTAWRALEEAATQHRPKFLLQTDPLPPVAMHGHIPPLNLGIAGAHQFFNAGLAVQLVRYWTRRYR-------GTAP--
A4ICG7/56-350              --AGVPKRRHRSFKDAMEVV----------ERMTGRRPNRCPDGFETTKRFIDRLGFA-PILERIRFVHVAGTKGKGTTSAYTAALLQAY--GFKVGLFTSPHLTDLRERTVIDGRLLDENTYAQYFFEFLDKYEALQYSDSQLDRDIASPSRANFFRFIFLLSLYIFEQEGVEVAVMEVGIGGRIDSTNTIPSE-VSIITSLGYDHMEILGNTIQEIASEKAGIMKSGVVCFAAPQTDHPETRLVLEKHARKVGAPLV-----LLDQNVLPIRSWPKLAIGGVHAIEDSKLALMAARCVASIPPILPLDEVEKSV--
A0A1G4IJA9/45-317          -----PTYRNRTLA------------------------NTSGKSAELVGLLVERLNMR-RCLDTLRFVHVAGTKGKGTTASYTAALLEAY--GLKVGLFTSPHVKDVRERIMVNNEVLPMDTFVHYFFQVVDCFVELAGADKEVTWDLPAP--CSFFCLMFLVSLVAFAGESVDVAVVEVGIGGSRDPTNIIIPE-ASVITALGIDHTEILGDTVEEIALQKAGIMKPGVVCYAAPQGDHPSTRRVLKDYAEGVDSPLV-----FADDVAVPTDGWPCLSIGGEHAVENSRLALLAARSVMGIPLTQPLDDVE-----
Q4Q1G0/52-346              -AAGVSKRRHRSFKDAMEVV----------ERMTGRRPNRCPDGFETTKRFIDRLGFA-PILERIRFVHVAGTKGKGTTSAYTAALLQAY--GFKVGLFTSPHLTDLRERTVVDGRLLDENAYAQYFFDFLDKYEALQYSDSQLDRDIASPSRANFFRFIFLLSLYIFEQEGVGVAVMEVGIGGRIDSTNTIPSE-VSIITSLGYDHMDILGNTIQEIASEKAGIMKPGVVCFAAPQTDHPETRSVLEKHARKVGAPLV-----LLDQNVLPIRSWPKLAIGGAHAIEDSKLALMAARRVASIPPILPLDEVEKS---
E9AT38/52-346              -TAGVSKRRHRSFKDAMEVV----------VRMTGRRPNRCPDGFETTKRFIDRLGFA-PILERIRFVHVAGTKGKGTTSAYTAALLQAY--GFKVGLFTSPHLTDLRERTVVDGRLLDENTYAQYFFEFLDKYEALQYSDSQLDRDIASPSRANFFRFIFLLSLYIFEQEGVEVAVMEAGIGGRIDSTNTIPSE-VSIITSLGYDHMEILGNTIQEIASEKAGIMKPGVVCFAAPQVDHPETRPVLEKHARKIGTPLV-----LLDRNMLPIHSWPKLAIGGVHAIEDSKLALMAARRIANIPPILPLDEVEKS---
A0A3Q8IJ59/56-350          --AGVPKRRHRSFKDAMEVV----------ERMTGRRPNRCPDGFETTKRFIDRLGFA-PILERIRFVHVAGTKGKGTTSAYTAALLQAY--GFKVGLFTSPHLTDLRERTVIDGRLLDENTYAQYFFEFLDKYEALQYSDSQLDRDIASPSRANFFRFIFLLSLYIFEQEGVEVAVMEVGIGGRIDSTNTIPSE-VSIITSLGYDHMEILGNTIQEIASEKAGIMKSGVVCFAAPQTDHPETRLVLEKHARKVGAPLV-----LLDQNVLPIRSWPKLAIGGVHAIEDSKLALMAARCVASIPPILPLDEVEKSV--
A0A180GUY9/32-324          ------------YDEAILALNSLQSNASVLAAIQAAGPQPSEQVFGQTTYYLRRLGYKPKDLNGLNAIHISGTKGKGSTAAFCSSLLNTINPSAKVGLFTSPHLVAVRERIRINGKPISEELFAKYFWQLWERFDDGNGEPVRT--DLPIR--PAYFRYLTYMAYHTFLAERVDASVLEVGVGGLLDPTNLIPSPIVTGVSSLGIDHVNVLGHSIAEIAGHKGGIFKPGVPALTV-QQHYPETIGVLRERAHELKAS------SFTIIPRRPDLEELEIGLAGSHQKHNAAFAIALVNTFLGSPR-RPPSYSQHAPA-
E9BTY3/56-350              --AGVPKRRHRSFKDAMEVV----------ERMTGRRPNRCPDGFETTKRFIDRLGFA-PILERIRFVHVAGTKGKGTTSAYTAALLQAY--GFKVGLFTSPHLTDLRERTVIDGRLLDENTYAQYFFEFLDKYEALQYSDSQLDRDIASPSRANFFRFIFLLSLYIFEQEGVEVAVMEVGIGGRIDSTNTIPSE-VSIITSLGYDHMEILGNTIQEIASEKAGIMKSGVVCFAAPQTDHPETRLVLEKHARKVGAPLV-----LLDQNVLPIRSWPKLAIGGVHAIEDSKLALMAARCVASIPPILPLDEVEKSV--
B4IGH5/87-375              ----NNKDTDAAFELAIKQLNSLQSND---AAIRNSMKNARVDTKADTIKYLERSGLPLETVERLSFIHVAGTKGKGSTCALTESLLRHQ--GVRTGFFSSPHILFTNERIRIDGQLLAKDKFTEQFWKVYSRLWDRREHDH----DM-----PAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTNIVRNVRTVGITSLGLEHTELLGCTLPEIAWQKAGIIKTGSHVFT--HVTQSECLEVIRQRAKENSATLY-EVPPTEDYFRSEAYAPIWQTFSNL-IRLNGSLAIQLAEDWLSQSG-----KHQHTP--
B4NUC1/87-375              ----NNKDTDAAFELAIKQLNSLQSND---AAIRNSMKNARVDTKADTIKYLERSGLPLETVERLSFIHVAGTKGKGSTCALTESLLRHQ--GVRTGFFSSPHILFTNERIRIDGQLLAKDKFTEQFWKVYSRLWDRREHDH----DM-----PAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTNIVRNVRTVGITSLGLEHTELLGCTLPEIAWQKAGIIKTGSHVFT--HVTQPECLEVIRQRAKENSATLY-EVPPTEDYFRSEAYAPIWQTFSNL-IRLNGSLAIQLAEDWLSQSG-----KHQHTP--
#=GC scorecons             001112323334642643242222121000334333236343543437336559564414365464679779899996947564699444007465969699963346996476745744537545955535553544336311019521200557955555655459347487658598979933949957444154477699479566994764999359799594854465217345865338654574534545301001435334343343434455634433654796356533453531132233433200
#=GC scorecons_70          ____________*__*______________________*________*__*__*_*_____*__*__**********_*_*_*__**_____*_*_*******_____***_***__*____*___*_____________*_____*________**_____*____*__*_***_*_******__*_**_*_______*****_**___**_*__***__****_*_*___*___*___**___**___*_____________________________________*__**___*_____________________
#=GC scorecons_80          _______________________________________________*_____*______________*********_*_*____**_____*___*_*_***_____**__*_*__*____*___*___________________*________**__________*__*_*___*_******__*_**_________**_**__*___**_*__***__****_*_*___________*____*____*________________________________________**_________________________
#=GC scorecons_90          _____________________________________________________*______________*__******_*______**_________*_*_***_____**________________*___________________*_________*__________*____*___*_***_**__*_**____________**__*___**____***__*_**_*_____________*____*______________________________________________*_________________________
//