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CATH Superfamily 3.40.1010.10

Tetrapyrrole methylase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cobalt-precorrin-4 Transmethylase; Domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Putative diphthine synthase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Diphthine methyl ester synthase. [EC: 2.1.1.314]
4 S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine- [translation elongation factor 2] = 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2].
  • This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide.
  • Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98).
  • The relevant histidine of elongation factor 2 is His(715) in mammals and His(699) in yeast.
 94 A0A0L8VLQ7 A0A0L8VLQ7 A0A0L8VLQ7 A0A0L8VLQ7 A0A0L8VLQ7 A0A0L8VLQ7 A0A0L8VLQ7 A0A0L8VLQ7 A0A0L8VLQ7 A0A2R9AF90
(84 more...)
Diphthine synthase. [EC: 2.1.1.98]
3 S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine- [translation elongation factor 2] = 3 S-adenosyl-L-homocysteine + diphthine-[translation elongation factor 2].
  • This archaeal enzyme produces the trimethylated product diphthine, which is converted into diphthamide by EC 6.3.1.14.
  • Different from the eukaryotic enzyme, which produces diphthine methyl ester (cf. EC 2.1.1.314).
  • In the archaeon Pyrococcus horikoshii the enzyme acts on His(600) of elongation factor 2.
 1 O58456
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