# STOCKHOLM 1.0 #=GF ID 3.30.70.890/FF/000015 #=GF DE Diphosphomevalonate decarboxylase #=GF AC 3.30.70.890/FF/000015 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 95.094 #=GS 2hkeB02/176-371 AC Q388P2 #=GS 2hkeB02/176-371 OS Trypanosoma brucei brucei TREU927 #=GS 2hkeB02/176-371 DE Diphosphomevalonate decarboxylase #=GS 2hkeB02/176-371 DR CATH; 2hke; B:176-371; #=GS 2hkeB02/176-371 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; #=GS 2hkeB02/176-371 DR GO; GO:0004163; GO:0005524; GO:0005654; GO:0005737; GO:0005929; GO:0016301; GO:0016310; #=GS Q4QE40/177-370 AC Q4QE40 #=GS Q4QE40/177-370 OS Leishmania major #=GS Q4QE40/177-370 DE Diphosphomevalonate decarboxylase #=GS Q4QE40/177-370 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania major species complex; Leishmania major; #=GS Q4QE40/177-370 DR GO; GO:0005654; GO:0005737; GO:0005929; #=GS Q388J2/181-371 AC Q388J2 #=GS Q388J2/181-371 OS Trypanosoma brucei brucei TREU927 #=GS Q388J2/181-371 DE Diphosphomevalonate decarboxylase #=GS Q388J2/181-371 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; #=GS Q388J2/181-371 DR GO; GO:0005737; #=GS Q9U2A1/150-326 AC Q9U2A1 #=GS Q9U2A1/150-326 OS Caenorhabditis elegans #=GS Q9U2A1/150-326 DE Diphosphomevalonate decarboxylase #=GS Q9U2A1/150-326 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis elegans; #=GS Q9U294/201-377 AC Q9U294 #=GS Q9U294/201-377 OS Caenorhabditis elegans #=GS Q9U294/201-377 DE Diphosphomevalonate decarboxylase #=GS Q9U294/201-377 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis elegans; #=GS W4Z112/126-319 AC W4Z112 #=GS W4Z112/126-319 OS Strongylocentrotus purpuratus #=GS W4Z112/126-319 DE Diphosphomevalonate decarboxylase #=GS W4Z112/126-319 DR ORG; Eukaryota; Metazoa; Echinodermata; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; Strongylocentrotus; Strongylocentrotus purpuratus; #=GS 2hkeA02/176-371 AC Q388P2 #=GS 2hkeA02/176-371 OS Trypanosoma brucei brucei TREU927 #=GS 2hkeA02/176-371 DE Diphosphomevalonate decarboxylase #=GS 2hkeA02/176-371 DR CATH; 2hke; A:176-371; #=GS 2hkeA02/176-371 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; #=GS 2hkeA02/176-371 DR GO; GO:0004163; GO:0005524; GO:0005654; GO:0005737; GO:0005929; GO:0016301; GO:0016310; #=GS A2EGU1/182-335 AC A2EGU1 #=GS A2EGU1/182-335 OS Trichomonas vaginalis #=GS A2EGU1/182-335 DE Diphosphomevalonate decarboxylase #=GS A2EGU1/182-335 DR ORG; Eukaryota; Trichomonadida; Trichomonadidae; Trichomonas; Trichomonas vaginalis; #=GS A0A1D6HN88/165-371 AC A0A1D6HN88 #=GS A0A1D6HN88/165-371 OS Zea mays #=GS A0A1D6HN88/165-371 DE Diphosphomevalonate decarboxylase #=GS A0A1D6HN88/165-371 DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Liliopsida; Petrosaviidae; Poales; Poaceae; Panicoideae; Andropogoneae; Tripsacinae; Zea; Zea mays; #=GS W5LZA1/191-384 AC W5LZA1 #=GS W5LZA1/191-384 OS Lepisosteus oculatus #=GS W5LZA1/191-384 DE Diphosphomevalonate decarboxylase #=GS W5LZA1/191-384 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; Lepisosteus; Lepisosteus oculatus; #=GS B7QEF4/194-345 AC B7QEF4 #=GS B7QEF4/194-345 OS Ixodes scapularis #=GS B7QEF4/194-345 DE Diphosphomevalonate decarboxylase #=GS B7QEF4/194-345 DR ORG; Eukaryota; Metazoa; Arthropoda; Chelicerata; Arachnida; Acari; Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes; Ixodes scapularis; #=GS F6Z0U1/189-379 AC F6Z0U1 #=GS F6Z0U1/189-379 OS Ciona intestinalis #=GS F6Z0U1/189-379 DE Diphosphomevalonate decarboxylase #=GS F6Z0U1/189-379 DR ORG; Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona; Ciona intestinalis; #=GS A0A1G4IB58/180-371 AC A0A1G4IB58 #=GS A0A1G4IB58/180-371 OS Trypanosoma equiperdum #=GS A0A1G4IB58/180-371 DE Diphosphomevalonate decarboxylase #=GS A0A1G4IB58/180-371 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma equiperdum; #=GS A4HXM8/177-370 AC A4HXM8 #=GS A4HXM8/177-370 OS Leishmania infantum #=GS A4HXM8/177-370 DE Diphosphomevalonate decarboxylase #=GS A4HXM8/177-370 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; #=GS A0A3L6KXM2/180-371 AC A0A3L6KXM2 #=GS A0A3L6KXM2/180-371 OS Trypanosoma brucei equiperdum #=GS A0A3L6KXM2/180-371 DE Diphosphomevalonate decarboxylase #=GS A0A3L6KXM2/180-371 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei equiperdum; #=GS E9BDI3/177-370 AC E9BDI3 #=GS E9BDI3/177-370 OS Leishmania donovani BPK282A1 #=GS E9BDI3/177-370 DE Diphosphomevalonate decarboxylase #=GS E9BDI3/177-370 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; #=GS A8XYB1/188-369 AC A8XYB1 #=GS A8XYB1/188-369 OS Caenorhabditis briggsae #=GS A8XYB1/188-369 DE Diphosphomevalonate decarboxylase #=GS A8XYB1/188-369 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis briggsae; #=GS Q388P2/180-371 AC Q388P2 #=GS Q388P2/180-371 OS Trypanosoma brucei brucei TREU927 #=GS Q388P2/180-371 DE Diphosphomevalonate decarboxylase #=GS Q388P2/180-371 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; #=GS Q388P2/180-371 DR GO; GO:0004163; GO:0005524; GO:0005654; GO:0005737; GO:0005929; GO:0016301; GO:0016310; #=GS A0A3S7WUN8/177-370 AC A0A3S7WUN8 #=GS A0A3S7WUN8/177-370 OS Leishmania donovani #=GS A0A3S7WUN8/177-370 DE Diphosphomevalonate decarboxylase #=GS A0A3S7WUN8/177-370 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; #=GS A0A3Q0K2A5/191-381 AC A0A3Q0K2A5 #=GS A0A3Q0K2A5/191-381 OS Ciona intestinalis #=GS A0A3Q0K2A5/191-381 DE Diphosphomevalonate decarboxylase #=GS A0A3Q0K2A5/191-381 DR ORG; Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona; Ciona intestinalis; #=GS A0A1R3MKD7/806-1012 AC A0A1R3MKD7 #=GS A0A1R3MKD7/806-1012 OS Zea mays #=GS A0A1R3MKD7/806-1012 DE Diphosphomevalonate decarboxylase MVD2 #=GS A0A1R3MKD7/806-1012 DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Liliopsida; Petrosaviidae; Poales; Poaceae; Panicoideae; Andropogoneae; Tripsacinae; Zea; Zea mays; #=GS A0A1R3MKD5/776-982 AC A0A1R3MKD5 #=GS A0A1R3MKD5/776-982 OS Zea mays #=GS A0A1R3MKD5/776-982 DE Diphosphomevalonate decarboxylase MVD2 #=GS A0A1R3MKD5/776-982 DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Liliopsida; Petrosaviidae; Poales; Poaceae; Panicoideae; Andropogoneae; Tripsacinae; Zea; Zea mays; #=GF SQ 22 2hkeB02/176-371 DETHWPEIQVMCAVLKGAQKDVSSTKGMQQSLKTSPLMKKRISETVPERMKIASRAIKARDFATFAEIAMLESDDLQEIC-ATTEPKITYATEDSYAMIRLVKAYNAKKGRTALAYTFDAGANCFLFVL-KEDLPEAVAMLMEHFPTPFEKFFFG---------DRELLEKVKVVS-----LPDEYKKLI--DHPKKPFEMLLQSPVGCGVKYL Q4QE40/177-370 DEKYWPEVQVMCAVLKGEKKDVSSTSGMQQSLKTSSMMRERIESIVPARMSAVKEAIQQRDFNQFAAIAMADSDDLQEIC-RTTKPPIQYATDDSYAMIRLIRAFNAKKGYNVMAYTFDAGANCFMFTL-KQDLPEVVVMLRAHFPTSWDKLLFH---------DADLLEKCKAYQ-----LPASFEGLI--DYPKKSFEMLLQSPMGQGI--V Q388J2/181-371 -----PEIQVMCAVLKGAQKDVSSTKGMQQSLKTSPLMKKRISETVPERMKIASRAIKARDFATFAEIAMLESDDLQEIC-ATTEPKITYATEDSYAMIRLVKAYNAKKGRTALAYTFDAGANCFLFVL-KEDLPEAVAMLMEHFPTPFEKFFFG---------DRELLEKVKVVS-----LPDEYKKLI--DHPKKPFEMLLQSPVGCGVKYL Q9U2A1/150-326 ------DLYCIILVFDDGRKKVGSSEGMRRSRETSQLLKHRIESIVPQRIQQIQEAYTSRNFEQLARVIMADSNQFHAVC-MDSTPPIRYLNEASWQLIDTVEEFNI--GGIRAAYTFDAGPNACVIVQ-KENASQFLKAVLQTIQVPSEDLQVI---------GKELAEQFD--------VPAEPTTK---------CSKLIMSPMGGGPQ-E Q9U294/201-377 ------DLYCIILVFDDGRKKVGSSEGMRRSRETSQLLKHRIESIVPQRIQQIQEAYTSRNFEQLARVIMADSNQFHAVC-MDSTPPIRYLNEASWQLIDTVEEFNI--GGIRAAYTFDAGPNACVIVQ-KENASQFLKAVLQTIQVPSEDLQVI---------GKELAEQFD--------VPAEPTTK---------CSKLIMSPMGGGPQ-E W4Z112/126-319 DENYWSEMRILILVVVDKNYFFGSEYNGHFSISPHLLGSFKILSITFRYMETMRKAIKDRDYRTFAELTMKDSNQMHAVC-LDTYPPISYMNDTSRSIVQMVHDYNSFHGETKACYTFDAGPNAVLYVL-EENVSEVLSLIHHSFPPSQDNKEYI-----------------RGLDSRIHDIPQGLQCAMKRDPNPGALKYIIHSKVGPGPQ-V 2hkeA02/176-371 DETHWPEIQVMCAVLKGAQKDVSSTKGMQQSLKTSPLMKKRISETVPERMKIASRAIKARDFATFAEIAMLESDDLQEIC-ATTEPKITYATEDSYAMIRLVKAYNAKKGRTALAYTFDAGANCFLFVL-KEDLPEAVAMLMEHFPTPFEKFFFG---------DRELLEKVKVVS-----LPDEYKKLI--DHPKKPFEMLLQSPVGCGVKYL A2EGU1/182-335 ----WEDFVVFSVIVSSKKKDVLSTKGMQSTVETVPWIHWRAQEVVPKRISDAKKFINEKDFASLAEIIMRESNELHANC-LATFPPIKYLNDESFKVVSAIHQLNDDHKINIAAYSFDAGPNPFVFTT-KEHEKAVLDKLHEIGIEESSITRAT---------------------------PCEG---------------------------I A0A1D6HN88/165-371 DETHWNDLVIIIAVVSSKQKETSSTSGMRDSVETSPLLQYRAQTVVPGRVLKMEEAIKNRDFESFAKLTCADSNQFHAVC-LDTSPPIFYMNDTSHRIISLVEKWNHSEGTPQVAYTFDAGPNAVLIAQNRKTAAHLLQKLLYYFPPQDNDLSSYLVGDKSILGVAGLHSMKDVEA-----LPAPPETKIPDQKFKGDVSYFICSRLGAGPK-V W5LZA1/191-384 AESHWPELRVLILVVSAERKLVGSTAGMQTSVETSPLLKFKKPLVVPAHPPVEGHCVVLDEFARRAANTFGKAIALGSSCLLTTHYNISVTNECSVKTTISLVNLNR-NANNKVAYTFDAGPNAVIYTL-QQHLEQFVELLKHFFPPETNGEQFV-----------------KGLPVRPASLSEELKASIGMDPTPKGISYIISTKVGPGPC-M B7QEF4/194-345 PENHWPEMRXXFDV----KKDTGSTQGMELSMLTSSLLEYRATKVVPQRMKDITEAIVNRNFHKFAEITMQESNQLHAVC-LDTYPPIRYMNLVSWDIVHLVHRYNRYYGTNKLAYSFDAGPNACLFML-EDSLSEVLSIVQHAFPSSLGNSDFF-----------------RG---------------------------------------A F6Z0U1/189-379 DETHWPELRVFILVVSSKQKSFGSTVGMQRSVETSALLKHRIENIVPHRIKVLKQAVLEKDFCLFAEICMKESNQLHAIC-MDTFPPLRYLNNVSEKIMNFVYSYNERCGSTRVAYTFDAGPNAFLFTL-APFAEDLANQIYQVFPPSKDCTDTF----------FKTTEEFSFPNGKI--VPDVTDC--------GLIEYVICTKPGPGPQ-I A0A1G4IB58/180-371 ----WPEIQVMCAVLKGAQKDVSSTKGMQQSLKTSPLMKKRISETVPERMKIASRAIKARDFATFAEIAMLESDDLQEIC-ATTEPKITYATEDSYAMIRLVKAYNAKKGRTALAYTFDAGANCFLFVL-KEDLPEAVAMLMEHFPTPFEKFFFG---------DRELLEKVKVVS-----LPDEYKKLI--DHPKKPFEMLLQSPVGCGVKYL A4HXM8/177-370 DEKYWPEVQVMCAVLKGEKKDVPSTAGMQQSLKTSPMMQERIASIVPARMNAVKEAIRHRDFNKFAAIAMADSDDLQEIC-RTTEPRIQYATEDSYAMIRLIRAFNAKKGYNAMAYTFDAGANCFMFTL-KQDLPEVVVMLRAHFPTSWDKMCFH---------DADLLEECKAYQ-----LPASFEGLI--DYPKKSLEMLLQSPVGQGI--V A0A3L6KXM2/180-371 ----WPEIQVMCAVLKGAQKDVSSTKGMQQSLKTSPLMKKRISETVPERMKIASRAIKARDFATFAEIAMLESDDLQEIC-ATTEPKITYATEDSYAMIRLVKAYNAKKGRTALAYTFDAGANCFLFVL-KEDLPEAVAMLMEHFPTPFEKFFFG---------DRELLEKVKVVS-----LPDEYKKLI--DHPKKPFEMLLQSPVGCGVKYL E9BDI3/177-370 DEKYWPEVQVMCAVLKGEKKDVPSTAGMQQSLKTSPMMQERIASIVPARMNAVKEAIRHRDFNKFAAIAMADSDDLQEIC-RTTEPRIQYATEDSYAMIRLIRAFNAKKGYNAMAYTFDAGANCFMFTL-KQDLPEVVVMLRAHFPTSWDKMCFH---------DADLLEECKAYQ-----LPASFEGLI--DYPKKSLEMLLQSPVGQGI--V A8XYB1/188-369 -SENWPDLYCIILVFNDERKKVGSSEGMRRTRETSTLLKHRIEYVVPERIEQVKKAYESRNFQDLARVIMADSNQFHAVC-LDSIPPIRYLNESSWRLIELVEKFNQ--QEVKAAYTFDAGPNACVIVQ-KYDVPAFIRTLLQDIIIPSEDLKSV---------EEELKVSFD--------CPSESNSPI-------LCSKLIVSPMGGGP--- Q388P2/180-371 ----WPEIQVMCAVLKGAQKDVSSTKGMQQSLKTSPLMKKRISETVPERMKIASRAIKARDFATFAEIAMLESDDLQEIC-ATTEPKITYATEDSYAMIRLVKAYNAKKGRTALAYTFDAGANCFLFVL-KEDLPEAVAMLMEHFPTPFEKFFFG---------DRELLEKVKVVS-----LPDEYKKLI--DHPKKPFEMLLQSPVGCGVKYL A0A3S7WUN8/177-370 DEKYWPEVQVMCAVLKGEKKDVPSTAGMQQSLKTSPMMQERIASIVPARMNAVKEAIRHRDFNKFAAIAMADSDDLQEIC-RTTEPRIQYATEDSYAMIRLIRAFNAKKGYNAMAYTFDAGANCFMFTL-KQDLPEVVVMLRAHFPTSWDKMCFH---------DADLLEECKAYQ-----LPASFEGLI--DYPKKSLEMLLQSPVGQGI--V A0A3Q0K2A5/191-381 DETHWPELRVFILVVSSKQKSFGSTVGMQRSVETSALLKHRIENIVPHRIKVLKQAVLEKDFCLFAEICMKESNQLHAIC-MDTFPPLRYLNNVSEKIMNFVYSYNERCGSTRVAYTFDAGPNAFLFTL-APFAEDLANQIYQVFPPSKDCTDTF----------FKTTEEFSFPNGKI--VPDVTDC--------GLIEYVICTKPGPGPQ-I A0A1R3MKD7/806-1012 DETHWNDLVIIIAVVSSKQKETSSTSGMRDSVETSPLLQYRAQTVVPGRVLKMEEAIKNRDFESFAKLTCADSNQFHAVC-LDTSPPIFYMNDTSHRIISLVEKWNHSEGTPQVAYTFDAGPNAVLIAQNRKTAAHFLQKLLYYFPPQDNDLSSYLVGDKSILGDAGLHSMKDVEA-----LPAPPDTKIPDQKFKGDVSYFICSRLGAGPK-V A0A1R3MKD5/776-982 DETHWNDLVIIIAVVSSKQKETSSTSGMRDSVETSPLLQYRAQTVVPGRVLKMEEAIKNRDFESFAKLTCADSNQFHAVC-LDTSPPIFYMNDTSHRIISLVEKWNHSEGTPQVAYTFDAGPNAVLIAQNRKTAAHFLQKLLYYFPPQDNDLSSYLVGDKSILGDAGLHSMKDVEA-----LPAPPDTKIPDQKFKGDVSYFICSRLGAGPK-V #=GC scorecons 2323647535444853435845496388637458757553853358837533445763377833694546468656655904573858384653934563573459322734448979999695565550544445453363436644253324300000000022342322421200000473333223002112223434525446263204 #=GC scorecons_70 ____*_*______*_____*___**_**__*__**_*___*____**_*______*___***__**___*_**__**__*___*_*_*_*_*__*___*__*___*___*____*********_________________*___**____________________________________*________________________*_*____ #=GC scorecons_80 ______*______*_____*___*__**__*__**_____*____**_*______*___*_*___*______*______*___*_*_*_*____*______*___*________*******_*___________________________________________________________*_______________________________ #=GC scorecons_90 _____________*_____*___*__**_____*______*____**______________*___*______*______*_____*_*_*____*__________*________**_****_*___________________________________________________________________________________________ //