# STOCKHOLM 1.0
#=GF ID 3.30.572.10/FF/000011
#=GF DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GF AC 3.30.572.10/FF/000011
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 29.475
#=GS P07382/228-520      AC P07382
#=GS P07382/228-520      OS Leishmania major
#=GS P07382/228-520      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS P07382/228-520      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania major species complex; Leishmania major; 
#=GS P07382/228-520      DR GO; GO:0005737; 
#=GS P07382/228-520      DR EC; 1.5.1.3; 2.1.1.45; 
#=GS Q582G3/240-527      AC Q582G3
#=GS Q582G3/240-527      OS Trypanosoma brucei brucei TREU927
#=GS Q582G3/240-527      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS Q582G3/240-527      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; 
#=GS Q582G3/240-527      DR GO; GO:0004146; GO:0005737; GO:0005739; GO:0006545; GO:0009165; GO:0010608; GO:0046105; 
#=GS Q27783/240-527      AC Q27783
#=GS Q27783/240-527      OS Trypanosoma brucei brucei
#=GS Q27783/240-527      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS Q27783/240-527      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; 
#=GS Q27783/240-527      DR EC; 1.5.1.3; 2.1.1.45; 
#=GS A0A3P3YY75/232-521  AC A0A3P3YY75
#=GS A0A3P3YY75/232-521  OS Leishmania braziliensis MHOM/BR/75/M2904
#=GS A0A3P3YY75/232-521  DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS A0A3P3YY75/232-521  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Viannia; Leishmania braziliensis species complex; Leishmania braziliensis; 
#=GS A0A1G4IK32/240-527  AC A0A1G4IK32
#=GS A0A1G4IK32/240-527  OS Trypanosoma equiperdum
#=GS A0A1G4IK32/240-527  DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS A0A1G4IK32/240-527  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma equiperdum; 
#=GS P16126/229-520      AC P16126
#=GS P16126/229-520      OS Leishmania amazonensis
#=GS P16126/229-520      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS P16126/229-520      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania amazonensis; 
#=GS P16126/229-520      DR EC; 1.5.1.3; 2.1.1.45; 
#=GS A0A3S5H5T0/228-520  AC A0A3S5H5T0
#=GS A0A3S5H5T0/228-520  OS Leishmania donovani
#=GS A0A3S5H5T0/228-520  DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS A0A3S5H5T0/228-520  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; 
#=GS A0A088S2I0/232-521  AC A0A088S2I0
#=GS A0A088S2I0/232-521  OS Leishmania panamensis
#=GS A0A088S2I0/232-521  DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS A0A088S2I0/232-521  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Viannia; Leishmania guyanensis species complex; Leishmania panamensis; 
#=GS Q8MQV3/228-520      AC Q8MQV3
#=GS Q8MQV3/228-520      OS Leishmania infantum
#=GS Q8MQV3/228-520      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS Q8MQV3/228-520      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; 
#=GS E9AKW4/232-520      AC E9AKW4
#=GS E9AKW4/232-520      OS Leishmania mexicana MHOM/GT/2001/U1103
#=GS E9AKW4/232-520      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS E9AKW4/232-520      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania mexicana; 
#=GS A4H4P8/232-521      AC A4H4P8
#=GS A4H4P8/232-521      OS Leishmania braziliensis
#=GS A4H4P8/232-521      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS A4H4P8/232-521      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Viannia; Leishmania braziliensis species complex; Leishmania braziliensis; 
#=GS E9B8U9/228-520      AC E9B8U9
#=GS E9B8U9/228-520      OS Leishmania donovani BPK282A1
#=GS E9B8U9/228-520      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS E9B8U9/228-520      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; 
#=GF SQ 12
P07382/228-520              VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETSAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKEERQYLEDYELTDMEVIDYVPHPAIKMEMAV
Q582G3/240-527              ---NSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFGADYISCKEDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVS--NGELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEMAV
Q27783/240-527              ---NSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFGADYISCKVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVS--NGELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEMAV
A0A3P3YY75/232-521          ---NHEERQYLELIDRIMKTGIAKEDRTGVGILSLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTANKEMDLGPVYGFQWRHFGAQYKGFEANYDGEGVDQIKSIVETIKVNPNDRRLLLTAWNPCALHEMALPPCHLLAQFYVNTDAKELSCMLYQRSCDMGLGVPFNIASYALLTILMAKATGLRPGELVHTLGDAHVYRNHIDALKVQLERTPNAFPTLVFKREREFLEDYELSDMEVIDYAPYPPIKMEMAV
A0A1G4IK32/240-527          ---NSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFGADYISCKEDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVS--NGELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEMAV
P16126/229-520              -PRNHEERQYLELIDRIMKTGIAKEDRTGVGTLSLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENTEMDLGPVYGFQWRHFGAEYRGLEANYDGEGVDQIKFIVETIKANPNDRRLLFTAWNPCALHKMALPPCHLLAQFYVNTEKSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRSHIDALKAQLERVPHAFPTLVFKEERQFLEDYELMDMEVIDYVPHPPIKMEMAV
A0A3S5H5T0/228-520          VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDMEVIDYVPHPPIKMEMAV
A0A088S2I0/232-521          ---NHEERQYLELIDRIMKTGIVKEDRTGVGILSLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTANKEMDLGPVYGFQWRHFGAQYKGFEANYDGEGVDQIKSIVETIKVNPNDRRLLLTAWNPCALHEMALPPCHLLAQFYVNTDAKELSCMLYQRSCDMGLGVPFNIASYALLTILMAKATGLRPGELVHTLGDAHVYRNHIDALKVQLERTPNAFPTLVFKREREFLEDYELSDMEVIDYAPYPPIKMEMAV
Q8MQV3/228-520              VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDMEVIDYVPHPPIKMEMAV
E9AKW4/232-520              ----HEERQYLELIDRIMKTGIAKEDRTGVGTLSLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENTEMDLGPVYGFQWRHFGAEYRGLEANYDGEGVDQIKFIVETIKANPNDRRLLFTAWNPCALHKMALPPCHLLAQFYVNTEKSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRSHIGALKAQLERVPHAFPTLVFKEERQFLEDYELMDMEVIDYVPHPAIKMDMAV
A4H4P8/232-521              ---NHEERQYLELIDRIMKTGIAKEDRTGVGILSLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTANKEMDLGPVYGFQWRHFGAQYKGFEANYDGEGVDQIKSIVETIKVNPNDRRLLLTAWNPCALHEMALPPCHLLAQFYVNTDAKELSCMLYQRSCDMGLGVPFNIASYALLTILMAKATGLRPGELVHTLGDAHVYRNHIDALKVQLERTPNAFPTLVFKREREFLEDYELSDMEVIDYAPYPPIKMEMAV
E9B8U9/228-520              VPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDMEVIDYVPHPPIKMEMAV
#=GC scorecons              00075995999697699655955949999997399999999999969999999999999999999999999999896996996999999999959999999955499999999999999999694646565796999994499666449969996649999959955999999966999996324499999999999999999999999999995969996999999999999999995797564739969695699568995776899976459699999497949598999
#=GC scorecons_70           ___*_**_***_**_***__*__*_*******_**********************************************_**_**********_********___*****************_*_____*_**_*****__**__*__********_*****_**__**************_____****************************_*****_*****************_***___*_**_***__**_****_*********__*******_***_*_*****
#=GC scorecons_80           ___*_**_***_*__**___*__*_******__************_******************************_**_**_**********_********___*****************_*________*_*****__**_____**_***___*****_**__*******__*****_____****************************_*_***_*****************_**______**_*_*__**__***____*****___*_*****_*_*_*_*****
#=GC scorecons_90           _____**_***_*__**___*__*_******__************_******************************_**_**_**********_********___*****************_*________*_*****__**_____**_***___*****_**__*******__*****_____****************************_*_***_*****************__*______**_*_*__**__***____****____*_*****_*_*_*_*****
//