# STOCKHOLM 1.0
#=GF ID 3.30.565.10/FF/000097
#=GF DE DNA topoisomerase 2
#=GF AC 3.30.565.10/FF/000097
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 80.722
#=GS P34534/50-296          AC P34534
#=GS P34534/50-296          OS Caenorhabditis elegans
#=GS P34534/50-296          DE Putative DNA topoisomerase 2, mitochondrial
#=GS P34534/50-296          DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis elegans; 
#=GS P34534/50-296          DR EC; 5.6.2.3; 
#=GS P90520/94-134_165-371  AC P90520
#=GS P90520/94-134_165-371  OS Dictyostelium discoideum
#=GS P90520/94-134_165-371  DE DNA topoisomerase 2, mitochondrial
#=GS P90520/94-134_165-371  DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium discoideum; 
#=GS P90520/94-134_165-371  DR GO; GO:0005739; 
#=GS P90520/94-134_165-371  DR EC; 5.6.2.3; 
#=GS B8C981/10-266          AC B8C981
#=GS B8C981/10-266          OS Thalassiosira pseudonana
#=GS B8C981/10-266          DE DNA topoisomerase 2
#=GS B8C981/10-266          DR ORG; Eukaryota; Bacillariophyta; Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales; Thalassiosiraceae; Thalassiosira; Thalassiosira pseudonana; 
#=GS A2E5K0/20-266          AC A2E5K0
#=GS A2E5K0/20-266          OS Trichomonas vaginalis
#=GS A2E5K0/20-266          DE DNA topoisomerase 2
#=GS A2E5K0/20-266          DR ORG; Eukaryota; Trichomonadida; Trichomonadidae; Trichomonas; Trichomonas vaginalis; 
#=GS A0D9B8/13-251          AC A0D9B8
#=GS A0D9B8/13-251          OS Paramecium tetraurelia
#=GS A0D9B8/13-251          DE DNA topoisomerase 2
#=GS A0D9B8/13-251          DR ORG; Eukaryota; Ciliophora; Intramacronucleata; Oligohymenophorea; Peniculida; Parameciidae; Paramecium; Paramecium tetraurelia; 
#=GS A0A081A4L9/116-374     AC A0A081A4L9
#=GS A0A081A4L9/116-374     OS Phytophthora parasitica P1976
#=GS A0A081A4L9/116-374     DE DNA topoisomerase 2
#=GS A0A081A4L9/116-374     DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora parasitica; 
#=GS F0ZB94/89-362          AC F0ZB94
#=GS F0ZB94/89-362          OS Dictyostelium purpureum
#=GS F0ZB94/89-362          DE DNA topoisomerase 2
#=GS F0ZB94/89-362          DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium purpureum; 
#=GS A0A0W8DMU8/1-247       AC A0A0W8DMU8
#=GS A0A0W8DMU8/1-247       OS Phytophthora nicotianae
#=GS A0A0W8DMU8/1-247       DE DNA topoisomerase 2
#=GS A0A0W8DMU8/1-247       DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora nicotianae; 
#=GS H3GJQ6/117-375         AC H3GJQ6
#=GS H3GJQ6/117-375         OS Phytophthora ramorum
#=GS H3GJQ6/117-375         DE DNA topoisomerase 2
#=GS H3GJQ6/117-375         DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora ramorum; 
#=GS A0C0L0/13-251          AC A0C0L0
#=GS A0C0L0/13-251          OS Paramecium tetraurelia
#=GS A0C0L0/13-251          DE DNA topoisomerase 2
#=GS A0C0L0/13-251          DR ORG; Eukaryota; Ciliophora; Intramacronucleata; Oligohymenophorea; Peniculida; Parameciidae; Paramecium; Paramecium tetraurelia; 
#=GS A0C7Z3/1-239           AC A0C7Z3
#=GS A0C7Z3/1-239           OS Paramecium tetraurelia
#=GS A0C7Z3/1-239           DE DNA topoisomerase 2
#=GS A0C7Z3/1-239           DR ORG; Eukaryota; Ciliophora; Intramacronucleata; Oligohymenophorea; Peniculida; Parameciidae; Paramecium; Paramecium tetraurelia; 
#=GS W2L2M6/116-374         AC W2L2M6
#=GS W2L2M6/116-374         OS Phytophthora parasitica
#=GS W2L2M6/116-374         DE DNA topoisomerase 2
#=GS W2L2M6/116-374         DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora parasitica; 
#=GS V9F0Y7/116-374         AC V9F0Y7
#=GS V9F0Y7/116-374         OS Phytophthora parasitica P1569
#=GS V9F0Y7/116-374         DE DNA topoisomerase 2
#=GS V9F0Y7/116-374         DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora parasitica; 
#=GS W2RA79/116-374         AC W2RA79
#=GS W2RA79/116-374         OS Phytophthora parasitica INRA-310
#=GS W2RA79/116-374         DE DNA topoisomerase 2
#=GS W2RA79/116-374         DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora parasitica; 
#=GS W2WXT7/116-374         AC W2WXT7
#=GS W2WXT7/116-374         OS Phytophthora parasitica CJ01A1
#=GS W2WXT7/116-374         DE DNA topoisomerase 2
#=GS W2WXT7/116-374         DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora parasitica; 
#=GS W2NBB8/116-374         AC W2NBB8
#=GS W2NBB8/116-374         OS Phytophthora parasitica
#=GS W2NBB8/116-374         DE DNA topoisomerase 2
#=GS W2NBB8/116-374         DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora parasitica; 
#=GS W2IYD9/116-374         AC W2IYD9
#=GS W2IYD9/116-374         OS Phytophthora parasitica
#=GS W2IYD9/116-374         DE DNA topoisomerase 2
#=GS W2IYD9/116-374         DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora parasitica; 
#=GS W2GQ67/116-374         AC W2GQ67
#=GS W2GQ67/116-374         OS Phytophthora parasitica
#=GS W2GQ67/116-374         DE DNA topoisomerase 2
#=GS W2GQ67/116-374         DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora parasitica; 
#=GS A0A0W8CH21/116-374     AC A0A0W8CH21
#=GS A0A0W8CH21/116-374     OS Phytophthora nicotianae
#=GS A0A0W8CH21/116-374     DE DNA topoisomerase 2
#=GS A0A0W8CH21/116-374     DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora nicotianae; 
#=GS W2Z717/116-374         AC W2Z717
#=GS W2Z717/116-374         OS Phytophthora parasitica P10297
#=GS W2Z717/116-374         DE DNA topoisomerase 2
#=GS W2Z717/116-374         DR ORG; Eukaryota; Oomycetes; Peronosporales; Peronosporaceae; Phytophthora; Phytophthora parasitica; 
#=GF SQ 20
P34534/50-296                  KSPTEHVLLRPDTYIGGVAMREDQIIWLRDS-------ENRKMIA--------------------------KEVTYPPGLLKIFDEILVNAADNKARDSS---MNRLEVWLDRETAR------ISVWNNGSGLPVEIHPTEG----IYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIK----RRFRQKWYDNMKKCNEAEVVEILDETVK-----DYTKVEFVPDLERF----QIDKL-SDDVIDLIGRRVFEVAATLPRDVDVYLNGQKCDVDGFEDYVKMFNDS-
P90520/94-134_165-371          KTPTEHVLLRPDSYIGTIEKIEDDMWVLSNSMFN----KEKKTIE--------------------------IKATYIPGLLKIYDEILVNAADNKKRDSK---MSFIKVEINPNENS------ISIMNDGKGIPVVMHQTEN----CYVVEMVMGNLMSGSNFNDSELKVVGGRNGFGAKLTNIFSKEFTVETVDKSSG----KKYFQRWSNNMGDRSEPIITPI-GEGES-----DYTKITFKPDLEKF----KIKSLWDDNILQLMERRLYDIAGCN-TELMVTLNGKRLNYN-FQSYVKLYEHH-
B8C981/10-266                  KTPLEHILLRPSMYIGPTEHADPKSCSSTNS--------PWTMQR--------------------------QELSYVPALLKIFDEILVNASDNRLRHPGS--CNHFPSSSDP---------YISITNNGKSIPIQIHRKEN----MYIPELLFGHLLTGSNFNDDQKRLTGGRHGYGAKLTNVFSKQFVVEIGDGHSSKGKIKTYKQVWEDNMSVCHEAEVVSRDKKDADGKGNLDYTRISFIPDLARLTGDRKTEML-PEEEYQLMKRRVVDIAGCSGGKLTVTLNGEEISVSGFEDYANLYRQP-
A2E5K0/20-266                  LTHREHVLTRPDSYIGSIEPRECKMWVCN---------EDGKFEF--------------------------REISYVPGLYKIFDEILVNAADNKQRDPP---LTTIKVEVDPAQNR------ISVWNDGKGISTQKQFSPNDNCEYYIPEFIFSQLLTSSNYNDKQEKVTGGRNGYGAKLANIFSKKFHINIYNADEG----INYQQTITDNMTNIQPPKLKN--GKGKG-----SYTEISFWPDLERF----NLQTI-TKDHVDLIRRRVYDLAGIL-PKVKIFWNGNQVPIKKWEDYCKVYLKED
A0D9B8/13-251                  MTHIEHILQRPDTYIGSIQRTSEQMWIIQNG----------KMIQ--------------------------KEIEYVPGFFKIFDEILVNAADNLQRDSRQHKQSYIKVDIG---NE------ISIKNDGFPIPVEIHKEYQ----IYVPELIFGVFLTGSNFDDTEKRVVGGRNGYGAKLTNVYSTEFTLEVCDGK------SYFKLVWNNNMSNKQIPIIKQI-KKD-------PYVSISYKPDYKRF----GMKEI-ESDTQALLTRRVYDLAGIYGNKISVYLNDEKIKINSFQKYVDLYLPN-
A0A081A4L9/116-374             KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----LRYKQVWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDIAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
F0ZB94/89-362                  KTPTEHVLLRPDSYIGTIEKIEDDMWVLSNSMFN----KKTKTVEKKNAQVSETDNQSSDKSSKNKTFIQPIKATYVPGLLKIYDEILVNAADNKKRDST---MSFIKVEINPNKGT------ISIMNDGKGIPIVMHSTEN----CYVVEMVMGNLMSGSNFNDNELKVVGGRNGFGAKLTNIFSKEFVVETIDKSSG----KKYYQKWSNNMSNREDPIITNI-KEGEQ-----DYTKITFTPDLEKF----KTNSLWDDDILQLMEKRLYDIAGCN-PEVNVYLNGVQLNYD-FEKYVKLYEHH-
A0A0W8DMU8/1-247               ------------MYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----LRYKQVWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDIAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
H3GJQ6/117-375                 KTPLEHVLLRPGMYIGSVEATKDTMWMVPPESSASED-GGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHIDVVVEPGNKANGYRPWISVHNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDSNARLTGGRHGYGAKLTNIFSKEFVVETGDSSMG----LRYKQVWHNNMRTRGEPEITEFKGKDAK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVFDVAGCL-SDVEVTLNGKKVPISGFESYIQAFCHST
A0C0L0/13-251                  MTHIEHILQRPDTYIGSIQRTSEQMWIIQNG----------KMIQ--------------------------KEIEYVPGFFKIFDEILVNAADNLQRDTRQHKQSYIKVDIG---NE------ITIKNDGLPIPVEIHKEYQ----IYVPELIFGVFLTGSNFDDSEKRVVGGRNGYGAKLTNVYSTEFTLEVCDGN------NYFKLVWNNNMSNKQIPTIKQL-KKD-------PYVSISYKPDYKRF----GMKEI-EADTQALLTRRVYDLAGIYGSKINVYLNDEKIKINSFQKYVDLYLPT-
A0C7Z3/1-239                   MSHIEHILNRPDTYIGSVQKMNELMWIVKNG----------KMIQ--------------------------KEIEYVPAFFKIFDDILVNAADNIQRNNQTYKMSSLRVEIG---NQ------ISVKNDGQPIPVEIHKEYQ----LYVPELIFGVSLTGSNFDDTEKRVVGGRNGYGAKLTNVYSSEFSVEVCDGS------NYLKQVWSNNMSNKQIPIIKQM-KKD-------PFVQITYKPDFKRF----GMNEI-EEDTQALLVRRVYDMAGIYGNRINVYLNDEKIPINSFQKYVDLYLPS-
W2L2M6/116-374                 KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----LRYKQVWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDIAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
V9F0Y7/116-374                 KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----SRYKQIWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDVAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
W2RA79/116-374                 KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----LRYKQVWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMQKL-TASMTRVLKKRVYDIAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
W2WXT7/116-374                 KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----LRYKQVWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDVAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
W2NBB8/116-374                 KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----LRYKQVWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDVAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
W2IYD9/116-374                 KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----SRYKQIWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDVAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
W2GQ67/116-374                 KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----LRYKQVWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDIAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
A0A0W8CH21/116-374             KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----LRYKQVWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDIAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
W2Z717/116-374                 KTPLEHVLLRPGMYIGSVEAAKDTMWMTPSESAAKEDEEGLRMKQ--------------------------QAVEYVPALYKIFDEIIVNAVDNKVRDPS---MRHLDVIIEPGNKANGYKPWISVYNDGKGIPVKFHKTEK----VYVPELVLGHLLTGSNFDDTAARLTGGRHGYGAKLTNIFSKEFVVETGDTSTG----LRYKQVWLNNMRTRGEPEITEFTGKDGK-----DFTKVSFSPDLEKF----EMEKL-TASMTRVLKKRVYDIAGCL-SDVEVTLNGKKVPISGFESYIQAFRHS-
#=GC scorecons                 56548868488549996664445377444441111111322663500000000000000000000000000445597967599898969995995397540005446483654224311111198739795688744855540000497787658467779986944375599969899997977967957853845240000347575737994454474744315762300000576576739966780000465460445434664797785985404564847974654654764954573540
#=GC scorecons_70              _*__****_**__***_**_____**_______________**________________________________***_*_**********_**__**__________*_*____________***_***__***__*_________******_*_*********___*__***_**************_**__*__________*_*_*_***_____*_*_____*_________**_***_***_**________*_______**_*****_**_____*_*_***_*_____**_*___*____
#=GC scorecons_80              ____**_*_**__***________*__________________________________________________***_*_******_***_**__**__________*______________***_***__**___*_________*****__*__******_*___*__***_***********_**_**__*______________*_***_____*_*_______________*____*_**___*____________________****_**_______*_**________*__*___*____
#=GC scorecons_90              ____**_*_**__***___________________________________________________________*_*___******_***_**__*__________________________**__*_*__**___*_________*______*_____***_*______***_******_*__*__*__*__*_________________**______________________________**___*____________________*__*_**_______*__*___________*________
//