The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52: DNA polymerase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
16 P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA)
(6 more)
3'-5'-exodeoxyribonuclease activity GO:0008296
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.
16 P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA)
(6 more)
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
14 Q48IT9 (/ISS) Q48IT9 (/ISS) Q48IT9 (/ISS) Q48IT9 (/ISS) Q48IT9 (/ISS) Q882K5 (/ISS) Q882K5 (/ISS) Q8EFZ4 (/ISS) Q9KSP4 (/ISS) Q9KSP4 (/ISS)
(4 more)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-dependent DNA replication GO:0006261
A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
16 P21189 (/IMP) P21189 (/IMP) P21189 (/IMP) P21189 (/IMP) P21189 (/IMP) P21189 (/IMP) P21189 (/IMP) P21189 (/IMP) P21189 (/IMP) P21189 (/IMP)
(6 more)
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
16 P21189 (/IEP) P21189 (/IEP) P21189 (/IEP) P21189 (/IEP) P21189 (/IEP) P21189 (/IEP) P21189 (/IEP) P21189 (/IEP) P21189 (/IEP) P21189 (/IEP)
(6 more)
DNA replication proofreading GO:0045004
Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.
16 P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA) P21189 (/IDA)
(6 more)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
14 Q48IT9 (/ISS) Q48IT9 (/ISS) Q48IT9 (/ISS) Q48IT9 (/ISS) Q48IT9 (/ISS) Q882K5 (/ISS) Q882K5 (/ISS) Q8EFZ4 (/ISS) Q9KSP4 (/ISS) Q9KSP4 (/ISS)
(4 more)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.