# STOCKHOLM 1.0
#=GF ID 3.30.1360.40/FF/000011
#=GF DE DNA topoisomerase 2
#=GF AC 3.30.1360.40/FF/000011
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 84.174
#=GS 2rgrA04/454-555      AC P06786
#=GS 2rgrA04/454-555      OS Saccharomyces cerevisiae S288C
#=GS 2rgrA04/454-555      DE DNA topoisomerase 2
#=GS 2rgrA04/454-555      DR CATH; 2rgr; A:872-973; 
#=GS 2rgrA04/454-555      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS 2rgrA04/454-555      DR GO; GO:0000019; GO:0000795; GO:0003918; GO:0005515; GO:0005634; GO:0005739; GO:0006265; GO:0006271; GO:0006333; GO:0007131; GO:0031055; GO:0042802; GO:0044774; GO:0097046; GO:0097047; 
#=GS 2rgrA04/454-555      DR EC; 5.6.2.3; 
#=GS P08096/925-1027      AC P08096
#=GS P08096/925-1027      OS Schizosaccharomyces pombe 972h-
#=GS P08096/925-1027      DE DNA topoisomerase 2
#=GS P08096/925-1027      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces; Schizosaccharomyces pombe; 
#=GS P08096/925-1027      DR GO; GO:0000070; GO:0000712; GO:0000790; GO:0003677; GO:0003918; GO:0005515; GO:0005524; GO:0005634; GO:0006265; GO:0006325; GO:0007076; GO:0034506; GO:0035327; GO:0051306; GO:0061505; 
#=GS P08096/925-1027      DR EC; 5.6.2.3; 
#=GS A0A1D8PMM1/932-1032  AC A0A1D8PMM1
#=GS A0A1D8PMM1/932-1032  OS Candida albicans SC5314
#=GS A0A1D8PMM1/932-1032  DE DNA topoisomerase 2
#=GS A0A1D8PMM1/932-1032  DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida; Candida albicans; 
#=GS A0A1D8PMM1/932-1032  DR GO; GO:0003918; GO:0009267; GO:0030447; GO:0036170; GO:0036178; GO:0036244; 
#=GS 1bjtA04/464-565      AC P06786
#=GS 1bjtA04/464-565      OS Saccharomyces cerevisiae S288C
#=GS 1bjtA04/464-565      DE DNA topoisomerase 2
#=GS 1bjtA04/464-565      DR CATH; 1bjt; A:872-973; 
#=GS 1bjtA04/464-565      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS 1bjtA04/464-565      DR GO; GO:0000019; GO:0000795; GO:0003918; GO:0005515; GO:0005634; GO:0005739; GO:0006265; GO:0006271; GO:0006333; GO:0007131; GO:0031055; GO:0042802; GO:0044774; GO:0097046; GO:0097047; 
#=GS 1bjtA04/464-565      DR EC; 5.6.2.3; 
#=GS 1bgwA04/464-565      AC P06786
#=GS 1bgwA04/464-565      OS Saccharomyces cerevisiae S288C
#=GS 1bgwA04/464-565      DE DNA topoisomerase 2
#=GS 1bgwA04/464-565      DR CATH; 1bgw; A:873-974; 
#=GS 1bgwA04/464-565      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS 1bgwA04/464-565      DR GO; GO:0000019; GO:0000795; GO:0003918; GO:0005515; GO:0005634; GO:0005739; GO:0006265; GO:0006271; GO:0006333; GO:0007131; GO:0031055; GO:0042802; GO:0044774; GO:0097046; GO:0097047; 
#=GS 1bgwA04/464-565      DR EC; 5.6.2.3; 
#=GS P06786/872-973       AC P06786
#=GS P06786/872-973       OS Saccharomyces cerevisiae S288C
#=GS P06786/872-973       DE DNA topoisomerase 2
#=GS P06786/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS P06786/872-973       DR GO; GO:0000019; GO:0000795; GO:0003918; GO:0005515; GO:0005634; GO:0005739; GO:0006265; GO:0006271; GO:0006333; GO:0007131; GO:0031055; GO:0042802; GO:0044774; GO:0097046; GO:0097047; 
#=GS P06786/872-973       DR EC; 5.6.2.3; 
#=GS P87078/932-1032      AC P87078
#=GS P87078/932-1032      OS Candida albicans
#=GS P87078/932-1032      DE DNA topoisomerase 2
#=GS P87078/932-1032      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida; Candida albicans; 
#=GS P87078/932-1032      DR EC; 5.6.2.3; 
#=GS A0A1D8NG10/965-1066  AC A0A1D8NG10
#=GS A0A1D8NG10/965-1066  OS Yarrowia lipolytica
#=GS A0A1D8NG10/965-1066  DE DNA topoisomerase 2
#=GS A0A1D8NG10/965-1066  DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia; Yarrowia lipolytica; 
#=GS Q755V8/880-981       AC Q755V8
#=GS Q755V8/880-981       OS Eremothecium gossypii ATCC 10895
#=GS Q755V8/880-981       DE DNA topoisomerase 2
#=GS Q755V8/880-981       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium; Eremothecium gossypii; 
#=GS R9XL70/880-981       AC R9XL70
#=GS R9XL70/880-981       OS Saccharomycetaceae sp. 'Ashbya aceri'
#=GS R9XL70/880-981       DE DNA topoisomerase 2
#=GS R9XL70/880-981       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomycetaceae sp. 'Ashbya aceri'; 
#=GS B9WF18/932-1032      AC B9WF18
#=GS B9WF18/932-1032      OS Candida dubliniensis CD36
#=GS B9WF18/932-1032      DE DNA topoisomerase 2
#=GS B9WF18/932-1032      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida; Candida dubliniensis; 
#=GS J6EDE8/941-1042      AC J6EDE8
#=GS J6EDE8/941-1042      OS Saccharomyces kudriavzevii IFO 1802
#=GS J6EDE8/941-1042      DE DNA topoisomerase 2
#=GS J6EDE8/941-1042      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces kudriavzevii; 
#=GS J8PZX9/872-973       AC J8PZX9
#=GS J8PZX9/872-973       OS Saccharomyces arboricola H-6
#=GS J8PZX9/872-973       DE DNA topoisomerase 2
#=GS J8PZX9/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces arboricola; 
#=GS A0A0L8VIX7/872-973   AC A0A0L8VIX7
#=GS A0A0L8VIX7/872-973   OS Saccharomyces sp. 'boulardii'
#=GS A0A0L8VIX7/872-973   DE DNA topoisomerase 2
#=GS A0A0L8VIX7/872-973   DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces sp. 'boulardii'; 
#=GS Q6C7Z9/965-1066      AC Q6C7Z9
#=GS Q6C7Z9/965-1066      OS Yarrowia lipolytica CLIB122
#=GS Q6C7Z9/965-1066      DE DNA topoisomerase 2
#=GS Q6C7Z9/965-1066      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia; Yarrowia lipolytica; 
#=GS A6ZRZ2/872-973       AC A6ZRZ2
#=GS A6ZRZ2/872-973       OS Saccharomyces cerevisiae YJM789
#=GS A6ZRZ2/872-973       DE DNA topoisomerase 2
#=GS A6ZRZ2/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS Q7LMA0/872-973       AC Q7LMA0
#=GS Q7LMA0/872-973       OS Saccharomyces cerevisiae
#=GS Q7LMA0/872-973       DE DNA topoisomerase 2
#=GS Q7LMA0/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS N1NXH6/872-973       AC N1NXH6
#=GS N1NXH6/872-973       OS Saccharomyces cerevisiae CEN.PK113-7D
#=GS N1NXH6/872-973       DE DNA topoisomerase 2
#=GS N1NXH6/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS B3LNU7/872-973       AC B3LNU7
#=GS B3LNU7/872-973       OS Saccharomyces cerevisiae RM11-1a
#=GS B3LNU7/872-973       DE DNA topoisomerase 2
#=GS B3LNU7/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS G2WM16/872-973       AC G2WM16
#=GS G2WM16/872-973       OS Saccharomyces cerevisiae Kyokai no. 7
#=GS G2WM16/872-973       DE DNA topoisomerase 2
#=GS G2WM16/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS C8ZGE3/872-973       AC C8ZGE3
#=GS C8ZGE3/872-973       OS Saccharomyces cerevisiae EC1118
#=GS C8ZGE3/872-973       DE DNA topoisomerase 2
#=GS C8ZGE3/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS C7GUN8/872-973       AC C7GUN8
#=GS C7GUN8/872-973       OS Saccharomyces cerevisiae JAY291
#=GS C7GUN8/872-973       DE DNA topoisomerase 2
#=GS C7GUN8/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E9P8H0/872-973       AC E9P8H0
#=GS E9P8H0/872-973       OS Saccharomyces cerevisiae
#=GS E9P8H0/872-973       DE DNA topoisomerase 2
#=GS E9P8H0/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E9P8G9/872-973       AC E9P8G9
#=GS E9P8G9/872-973       OS Saccharomyces cerevisiae
#=GS E9P8G9/872-973       DE DNA topoisomerase 2
#=GS E9P8G9/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E9P8H4/872-973       AC E9P8H4
#=GS E9P8H4/872-973       OS Saccharomyces cerevisiae
#=GS E9P8H4/872-973       DE DNA topoisomerase 2
#=GS E9P8H4/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E9P8H8/872-973       AC E9P8H8
#=GS E9P8H8/872-973       OS Saccharomyces cerevisiae
#=GS E9P8H8/872-973       DE DNA topoisomerase 2
#=GS E9P8H8/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E9P8H2/872-973       AC E9P8H2
#=GS E9P8H2/872-973       OS Saccharomyces cerevisiae
#=GS E9P8H2/872-973       DE DNA topoisomerase 2
#=GS E9P8H2/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GS E9P8H7/872-973       AC E9P8H7
#=GS E9P8H7/872-973       OS Saccharomyces cerevisiae
#=GS E9P8H7/872-973       DE DNA topoisomerase 2
#=GS E9P8H7/872-973       DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; 
#=GF SQ 28
2rgrA04/454-555              WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
P08096/925-1027              FRGSITKVAPDRYKISGIINQIGENKVEITELPIRFWTQDMKEYLEAGLVGTEKIRKFIVDYESHHGEGNVHFNVTLTEAGMKEALNESLEVKFKLSRTQATS
A0A1D8PMM1/932-1032          WGGDLEPMGPQKFKVSGRIEQIDSNTVEITEIPVKTWTNNVKEFLLSGF-GNEKTQPWIKDMEEHHT-TSIRFVVKLTDAEMQKSLRIGLLERFKLVSSLSLA
1bjtA04/464-565              WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
1bgwA04/464-565              WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
P06786/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
P87078/932-1032              WGGDLEPMGPQKFKVSGRIEQIDSNTVEITEIPVKTWTNNVKEFLLSGF-GNEKTQPWIKDMEEHHT-TSIRFVVKLTDAEMQKSLRIGLLERFKLVSSLSLA
A0A1D8NG10/965-1066          WHGEVEPVGDGRYKVKGLIEQVDERTLCITELPARMWTISMKEFLLSSLIDSKNEKGWIEDFTEDHG-FRVKFNITLSEKEMEKTRQIGLRERFKLISSLSTS
Q755V8/880-981               WNGTMQKIDAQRYRIFGRIEQVGENTVEITELPARTWTTTIKEHLLLALSGNERTKPWVKDMQEQHG-ATIKFVVTLTPEEMERTRKIGFYERFKLISTVSLS
R9XL70/880-981               WNGTMQKIDAHRYRIFGRIEQVGENTVEITELPARTWTTTIKEHLLLALSGNEKTKPWVKDMQEQHG-ATIKFVVTLTPEEMERTRKIGFYERFKLISTVSLS
B9WF18/932-1032              WGGDLEPMGPQKFKVSGRIEQIDSNTVEITEIPVKTWTNNVKEFLLSGF-GNEKTQPWIKDMEEHHT-TSIRFVVKLTDAEMQKSLRIGLLERFKLVSSLSLA
J6EDE8/941-1042              WTGTVEEIERLRYRMYGKIEQVGTNTLEITELPARTWTLTIKEYLLLGLSGSDKIKAWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLVSPISLM
J8PZX9/872-973               WSGTMEEIEPLRYRMYGRIEQVGSNTLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHN-DNIKFIITLSPEEMAKTRKIGFYERFKLIAPISLR
A0A0L8VIX7/872-973           WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
Q6C7Z9/965-1066              WHGEVEPVGDGRYKVKGLIEQVDERTLCITELPARMWTISMKEFLLSSLIDSKNEKGWIEDFTEDHG-FRVKFNITLSEKEMEKTRQIGLRERFKLISSLSTS
A6ZRZ2/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
Q7LMA0/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
N1NXH6/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
B3LNU7/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
G2WM16/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
C8ZGE3/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
C7GUN8/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNILEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
E9P8H0/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNILEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
E9P8G9/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
E9P8H4/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
E9P8H8/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
E9P8H2/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
E9P8H7/872-973               WTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISLM
#=GC scorecons               7494564655377764959797657566999796769945699697467376675657869667594035769576964579476557764789996755764
#=GC scorecons_70            *_*__*_*___***__*_*****_*_*********_**__******_**_**_*_*_**_*_**_*____***_***___**_**__***_*******__**_
#=GC scorecons_80            *_*________**___*_****__*___*****_*_**___**_**__*_*__*___**_*__*_*____*_*___*___**_*___**__*****_*__*__
#=GC scorecons_90            __*_____________*_*_*_______***_*___**___**_*_____________*_*____*______*___*____*__________****_______
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