# STOCKHOLM 1.0
#=GF ID 3.30.1360.170/FF/000001
#=GF DE Flavin-dependent thymidylate synthase
#=GF AC 3.30.1360.170/FF/000001
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 78.381
#=GS P15808/31-259      AC P15808
#=GS P15808/31-259      OS Dictyostelium discoideum
#=GS P15808/31-259      DE Flavin-dependent thymidylate synthase
#=GS P15808/31-259      DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium discoideum; 
#=GS P15808/31-259      DR GO; GO:0006231; GO:0045335; GO:0050797; 
#=GS P15808/31-259      DR EC; 2.1.1.148; 
#=GS O86840/7-246       AC O86840
#=GS O86840/7-246       OS Streptomyces coelicolor A3(2)
#=GS O86840/7-246       DE Flavin-dependent thymidylate synthase
#=GS O86840/7-246       DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group; Streptomyces coelicolor; 
#=GS O86840/7-246       DR EC; 2.1.1.148; 
#=GS Q7NI62/17-255      AC Q7NI62
#=GS Q7NI62/17-255      OS Gloeobacter violaceus PCC 7421
#=GS Q7NI62/17-255      DE Flavin-dependent thymidylate synthase
#=GS Q7NI62/17-255      DR ORG; Bacteria; Cyanobacteria; Gloeobacteria; Gloeobacterales; Gloeobacteraceae; Gloeobacter; Gloeobacter violaceus; 
#=GS D3BLB0/21-267      AC D3BLB0
#=GS D3BLB0/21-267      OS Heterostelium album PN500
#=GS D3BLB0/21-267      DE Thymidylate synthase
#=GS D3BLB0/21-267      DR ORG; Eukaryota; Acytosteliales; Acytosteliaceae; Heterostelium; Heterostelium album; 
#=GS F4PVH9/20-266      AC F4PVH9
#=GS F4PVH9/20-266      OS Cavenderia fasciculata SH3
#=GS F4PVH9/20-266      DE Thymidylate synthase
#=GS F4PVH9/20-266      DR ORG; Eukaryota; Acytosteliales; Cavenderiaceae; Cavenderia; Cavenderia fasciculata; 
#=GS F0ZE99/19-264      AC F0ZE99
#=GS F0ZE99/19-264      OS Dictyostelium purpureum
#=GS F0ZE99/19-264      DE Thymidylate synthase
#=GS F0ZE99/19-264      DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium purpureum; 
#=GS A0A3E0GPE3/7-246   AC A0A3E0GPE3
#=GS A0A3E0GPE3/7-246   OS Streptomyces sp. 2221.1
#=GS A0A3E0GPE3/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A3E0GPE3/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. 2221.1; 
#=GS A0A3E0GPE3/7-246   DR EC; 2.1.1.148; 
#=GS A0A1H2D0X0/7-246   AC A0A1H2D0X0
#=GS A0A1H2D0X0/7-246   OS Streptomyces sp. 2114.2
#=GS A0A1H2D0X0/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A1H2D0X0/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. 2114.2; 
#=GS A0A1H2D0X0/7-246   DR EC; 2.1.1.148; 
#=GS A0A397QCY4/7-246   AC A0A397QCY4
#=GS A0A397QCY4/7-246   OS Streptomyces sp. 19
#=GS A0A397QCY4/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A397QCY4/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. 19; 
#=GS A0A397QCY4/7-246   DR EC; 2.1.1.148; 
#=GS A0A3Q8VRT1/7-246   AC A0A3Q8VRT1
#=GS A0A3Q8VRT1/7-246   OS Streptomyces sp. KPB2
#=GS A0A3Q8VRT1/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A3Q8VRT1/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. KPB2; 
#=GS A0A2A2Z1Q6/7-246   AC A0A2A2Z1Q6
#=GS A0A2A2Z1Q6/7-246   OS Streptomyces sp. SA15
#=GS A0A2A2Z1Q6/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A2A2Z1Q6/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. SA15; 
#=GS A0A454W162/7-246   AC A0A454W162
#=GS A0A454W162/7-246   OS Streptomyces sp. WAC02707
#=GS A0A454W162/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A454W162/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. WAC02707; 
#=GS A0A3R9UHJ1/7-246   AC A0A3R9UHJ1
#=GS A0A3R9UHJ1/7-246   OS Streptomyces sp. WAC08401
#=GS A0A3R9UHJ1/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A3R9UHJ1/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. WAC08401; 
#=GS A0A399CG97/7-246   AC A0A399CG97
#=GS A0A399CG97/7-246   OS Streptomyces sp. SHP22-7
#=GS A0A399CG97/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A399CG97/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. SHP22-7; 
#=GS A0A0F7VV38/7-246   AC A0A0F7VV38
#=GS A0A0F7VV38/7-246   OS Streptomyces leeuwenhoekii
#=GS A0A0F7VV38/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A0F7VV38/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces leeuwenhoekii; 
#=GS A0A0C5G634/7-246   AC A0A0C5G634
#=GS A0A0C5G634/7-246   OS Streptomyces cyaneogriseus subsp. noncyanogenus
#=GS A0A0C5G634/7-246   DE Flavin-dependent thymidylate synthase
#=GS A0A0C5G634/7-246   DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces cyaneogriseus; Streptomyces cyaneogriseus subsp. noncyanogenus; 
#=GS A0A0M8WDH6/14-253  AC A0A0M8WDH6
#=GS A0A0M8WDH6/14-253  OS Streptomyces sp. NRRL WC-3618
#=GS A0A0M8WDH6/14-253  DE Flavin-dependent thymidylate synthase
#=GS A0A0M8WDH6/14-253  DR ORG; Bacteria; Actinobacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces sp. NRRL WC-3618; 
#=GF SQ 17
P15808/31-259              -------HRWEVKVHDHGKVALVDTMPRLAPVGQ------TADFSICQAARVSYGAGTKKVTE-------DKGLIRYLYRHQHTSPFEMVEFKFHCVMPVFIARQWIRHRTA-NVNEYSARYSVLP-DKFYHPSIEEVRKQSTSNRQGG--EEALEPKTAQEFL---DYLDKVEENYKTYNELLEKGLSRELGRIGLP-VSIYTEWYWKIDLHNLFHFLRLRMD-------SHSQKEIRDYANTIFALIRPIVPVACEAFIDYA-----------
O86840/7-246               ---------------DDPKIELRSDITVELVKSA------ATDSDVLFAARVS-TAGEQSLDELKKDPERSKGLINYLMRDRHGSPFEHNSMTFFVSAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYAP--DASRKLVQQGRPGK--YVFVEGTPEQHELVGSAMEDSYRQAYATYQQMLAAGVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMAGEKMEAEWARLMPLTHAAF-------NANGRVAP
Q7NI62/17-255              PGV--------IRVLDQGFIQLVDYMPSDYPFGQVVEGATAGDIAIVAAARVSYGTVTKGTDA-------DRKLIEFLLRHGHTSPLEMVEFKFIVKAPVVMWWQHVRHRIQ-EMNFQSGRYTPYPENEFYLP--EKLRAQDKVNKQGSVLVDFLSSDEERALL--EELRAHYEAGFSLYKKMLAKGVAKEMARLALPGWALYHTAYVKMNAHALMHYLAKRTE-------PDAQYEIRVYAQAMERIFAEKLPWVHDTW--------RNSRGA-
D3BLB0/21-267              YDVMNGSHRWEVKVHDHGKVALVDSMPRLAPVGQ------TADFAIVQAARVSYGAGTKKVTE-------DKGLIRYLYRHQHTSPFEMIEFKFHCVMPVFIARQWIRHRTA-NVNEYSARYSVMP-DKFYHPSAEDVRKQSTSNRQGG--EDATDTKTAQEFL---DYLDQVEANYKTYSELLDKGVSRELARIGLP-VSVYTEWYWKIDLHNLFHFLRLRMD-------SHSQKEIRDYANTIFALIRPIVPVACEAFIDYAFESIKLTRLEI
F4PVH9/20-266              YDVMKGSHRWEVKVHDHGNVALVDTMPRLAPVGQ------TADFAICQAARVSYGAGTKKVTE-------DTGLIRYLYRHQHTSPFEMIEFKFHCVMPIFIARQWIRHRTA-NVNEYSARYSVMP-DKFYHPSVEDVRKQSTSNRQGG--EDQMDTKTAQEFL---DYLDQAEECYKTYNNLLDKGVSRELARIGLP-VSVYTEWYWKIDLHNLFHFLRLRMD-------SHSQKEIRDYANAIFALIRPIVPVACEAFMDYAFESVKLTRLEI
F0ZE99/19-264              -DVMGGSHRWEVKVHDHGSVALVDSMPRLAPVGQ------TADFAICQAARVSYGAGTKKVSE-------DKGLIRYLYRHQHTSPFEMVEFKFHCVMPVFIARQWIRHRTA-NVNEYSARYSVMP-DKFYHPSAEDVRKQSVSNRQGG--EEQLEAKTAQEFL---DYLDKVEENYKTYNNLLEKGLSRELGRIGLP-VSIYTEWYWKIDLHNLFHFLRLRMD-------SHSQKEIRDYANTIFALIKPIVPVACEAFMDYAFESIKLTRLEI
A0A3E0GPE3/7-246           ---------------DDPKIELRSDITVELVKSA------ATDSDVLFAARVS-TAGEQSLDELKKDPERSKGLINYLMRDRHGSPFEHNSMTFFVSAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYAP--DASRKLVQQGRPGK--YVFVEGTPEQHELVGSAMEDSYRQAYATYQQMLAAGVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMAGEKMEAEWARLMPLTHAAF-------NANGRVAP
A0A1H2D0X0/7-246           ---------------DDPKIELRSDITVELVKSA------ATDSDVLFAARVS-TAGEQSLDELKKDPERSKGLINYLMRDRHGSPFEHNSMTFFVSAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYAP--DASRKLVQQGRPGK--YVFVEGTPEQHELVGSAMEDSYRQAYATYQQMLAAGVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMAGEKMEAEWARLMPLTHAAF-------NANGRVAP
A0A397QCY4/7-246           ---------------DDPKIELRSDITVELVKSA------ATDSDVLFAARVS-TAGEQSLDELKKDPERSKGLINYLMRDRHGSPFEHNSMTFFVSAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYAP--DASRKLVQQGRPGK--YVFVEGTPEQHELVGSAMEDSYRQAYATYQQMLAAGVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMAGEKMEAEWARLMPLTHAAF-------NANGRVAP
A0A3Q8VRT1/7-246           ---------------DDPKIELRSDITVELVKSA------ATDSDVLFAARVS-TAGEQSLDELKKDPERSKGLINYLMRDRHGSPFEHNSMTFFVSAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYVP--DTSRKLVQQGRPGK--YVFVEGTPEQHELVGGAMEDSHRQAYATYQKMLAAGVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMEEEWARLMPLTHAAF-------NANGRVAP
A0A2A2Z1Q6/7-246           ---------------DDFKIDLRSDVTVELVKHS------AADSDVLFAARVS-TVGEQSLDELKKDPERSKGLINFLMRDRHGSPFEHNSMTFFISAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYVP--DTSRKLVQQGRPGK--YVFVEGTPEQYELVGHAMEESYRQAYRTYQQMLAQGVAREVARAVLP-VGLFSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMEAEWAELMPLTHAAF-------NANGRVAP
A0A454W162/7-246           ---------------DDFKIDFRSDVTVELVKSS------ATDSDVLFAARVS-TAGEQSLDELRKDPERSKGLINYLMRDRHGSPFEHNSMTFFISAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYVP--APDRKLVQQGRPGK--YVFVEGTPEQHELVSRSMEDSYLQAYRTYQEMLAAGVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMEQEWARLMPLTYAAF-------NANGRVAP
A0A3R9UHJ1/7-246           ---------------DDFKIDFRSDVTVELVKSS------ATDSDVLFAARVS-TAGEQSLDELRKDPERSKGLINYLMRDRHGSPFEHNSMTFFISAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYVP--APDRKLVQQGRPGK--YVFVEGTPEQHELVSRSMEDSYLQAYRTYQEMLAAGVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMEQEWARLMPLTYAAF-------NANGRVAP
A0A399CG97/7-246           ---------------DDFKIDFRSDVTVELVKSS------ATDSDVLFAARVS-TAGEQSLDELRKDPERSKGLINYLMRDRHGSPFEHNSMTFFISAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYVP--APDRKLVQQGRPGK--YVFVEGTPEQHELVSRSMEDSYLQAYRTYQEMLAAGVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMEQEWARLMPLTYAAF-------NANGRVAP
A0A0F7VV38/7-246           ---------------DDFKIDLRSDVTVELVKHS------ASDADVLFAARVS-TVGEQSLDELNKDPERSKGLINFLLRDRHGSPFEHNSMTFFINAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYVP--DESRKLVQQGRPGK--YVFVEGTPAQHELVGRAMEDSYRQAYQTYRQMLAAGVAREVARSVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMEAEWARLMPLTYAAF-------NANGRVAP
A0A0C5G634/7-246           ---------------DDFKIDLRSDVTVELVKHS------ASDADVLFAARVS-TVGEQSLDELNKDPERSKGLINFLLRDRHGSPFEHNSMTFFINAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYVP--DESRKLVQQGRPGK--YVFVEGTPAQHELVGRAMEDSYRQAYQTYRQMLAAGVAREVARSVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMEAEWARLMPLTYAAF-------NANGRVAP
A0A0M8WDH6/14-253          ---------------DEFKIDLRSEVTVELVKHS------AADSDVLFAARVS-TVGDQSLDELGKDPERSTGLINYLMRDRHGSPFEHNSMTFFISAPIFVFREFMRHRVGWSYNEESGRYRELQ-PVFYVP--DTSRKLVQKGRPGK--YVFVEGTPEQHDLVGHAMEDSYRQAYRTYQQMLAQGVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMELEWARLMPLTHAAF-------NANGRVAP
#=GC scorecons             00100001111111195357474546644454440000006594574399999156756455721222225679957949559599795455595445977647646999552549749699445504499391053497544458594003445644557439211444744454847944695597689679449907568544945465659598957955222222274595995446546454454569555577011100034447443
#=GC scorecons_70          _______________*___*_*__________________*_*__*__*****__**_*___*________****_**_*__*_****_____*____****_**_****_____**_*_**_______**_*_____**_____*_*_______*____*__*______*_____*_**__**__**_**_**__**_*__*___*___*_*_*_***_**_________*__*_**______*________*____**___________*___
#=GC scorecons_80          _______________*_____*____________________*_____*****___*_____*_________***_**_*__*_****_____*____*_*__*___***_____*__*_**_______**_*_____**_____*_*____________*__*______*_____*_**___*__**_**__*__**_*__*___*_______*_***_**_________*__*_**_______________*____**___________*___
#=GC scorecons_90          _______________*__________________________*_____*****____________________**__*_*__*_**_*_____*____*________***_____*__*_**_______**_*_____*______*_*_______________*____________*__*___*__*__**__*__**____*___*_______*_***__*____________*_**_______________*_____________________
//