# STOCKHOLM 1.0 #=GF ID 3.20.20.450/FF/000009 #=GF DE Cyclic diguanylate phosphodiesterase #=GF AC 3.20.20.450/FF/000009 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 11.647 #=GS P77473/270-516 AC P77473 #=GS P77473/270-516 OS Escherichia coli K-12 #=GS P77473/270-516 DE Probable cyclic di-GMP phosphodiesterase PdeB #=GS P77473/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS P77473/270-516 DR GO; GO:0005886; GO:0071111; #=GS P77473/270-516 DR EC; 3.1.4.52; #=GS Q32JA2/191-437 AC Q32JA2 #=GS Q32JA2/191-437 OS Shigella dysenteriae Sd197 #=GS Q32JA2/191-437 DE Uncharacterized protein #=GS Q32JA2/191-437 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella dysenteriae; #=GS A0A0M7MSU5/270-516 AC A0A0M7MSU5 #=GS A0A0M7MSU5/270-516 OS Achromobacter sp. #=GS A0A0M7MSU5/270-516 DE Uncharacterized membrane protein YjcC #=GS A0A0M7MSU5/270-516 DR ORG; Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Achromobacter; Achromobacter sp.; #=GS A0A0M7MSU5/270-516 DR EC; 3.1.4.52; #=GS A0A3V4X5Z9/270-516 AC A0A3V4X5Z9 #=GS A0A3V4X5Z9/270-516 OS Salmonella enterica subsp. enterica #=GS A0A3V4X5Z9/270-516 DE EAL domain-containing protein #=GS A0A3V4X5Z9/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella; Salmonella enterica; Salmonella enterica subsp. enterica; #=GS A0A235K9L3/270-516 AC A0A235K9L3 #=GS A0A235K9L3/270-516 OS Shigella sonnei #=GS A0A235K9L3/270-516 DE Uncharacterized protein #=GS A0A235K9L3/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella sonnei; #=GS A0A235K9L3/270-516 DR EC; 3.1.4.52; #=GS A0A127GTG8/270-516 AC A0A127GTG8 #=GS A0A127GTG8/270-516 OS Shigella flexneri 4c #=GS A0A127GTG8/270-516 DE Uncharacterized protein #=GS A0A127GTG8/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella flexneri; #=GS W0ALD3/274-518 AC W0ALD3 #=GS W0ALD3/274-518 OS Escherichia albertii KF1 #=GS W0ALD3/274-518 DE Uncharacterized protein #=GS W0ALD3/274-518 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia albertii; #=GS A0A0E1LU23/270-516 AC A0A0E1LU23 #=GS A0A0E1LU23/270-516 OS Escherichia coli 1303 #=GS A0A0E1LU23/270-516 DE Putative membrane-anchored cyclic-di-GMP phosphodiesterase #=GS A0A0E1LU23/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A0E1LU23/270-516 DR EC; 3.1.4.52; #=GS A0A070SV60/270-516 AC A0A070SV60 #=GS A0A070SV60/270-516 OS Escherichia coli 2-210-07_S3_C3 #=GS A0A070SV60/270-516 DE EAL domain protein #=GS A0A070SV60/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A070SV60/270-516 DR EC; 3.1.4.52; #=GS A0A1X3JLK7/270-516 AC A0A1X3JLK7 #=GS A0A1X3JLK7/270-516 OS Escherichia coli H386 #=GS A0A1X3JLK7/270-516 DE Putative diguanylate phosphodiesterase #=GS A0A1X3JLK7/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A1X3JLK7/270-516 DR EC; 3.1.4.52; #=GS H4UFE5/270-516 AC H4UFE5 #=GS H4UFE5/270-516 OS Escherichia coli DEC6A #=GS H4UFE5/270-516 DE EAL domain protein #=GS H4UFE5/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS H4UFE5/270-516 DR EC; 3.1.4.52; #=GS A0A0E0TUU0/270-516 AC A0A0E0TUU0 #=GS A0A0E0TUU0/270-516 OS Escherichia coli UMNK88 #=GS A0A0E0TUU0/270-516 DE Uncharacterized protein #=GS A0A0E0TUU0/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A0E0TUU0/270-516 DR EC; 3.1.4.52; #=GS A0A069XQ52/270-516 AC A0A069XQ52 #=GS A0A069XQ52/270-516 OS Escherichia coli 3-373-03_S4_C2 #=GS A0A069XQ52/270-516 DE EAL domain protein #=GS A0A069XQ52/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A069XQ52/270-516 DR EC; 3.1.4.52; #=GS F4SJF5/270-516 AC F4SJF5 #=GS F4SJF5/270-516 OS Escherichia coli H736 #=GS F4SJF5/270-516 DE Putative diguanylate phosphodiesterase #=GS F4SJF5/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS F4SJF5/270-516 DR EC; 3.1.4.52; #=GS M9H7C9/270-516 AC M9H7C9 #=GS M9H7C9/270-516 OS Escherichia coli MP021561.2 #=GS M9H7C9/270-516 DE EAL domain protein #=GS M9H7C9/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS M9H7C9/270-516 DR EC; 3.1.4.52; #=GS A0A024L5T5/270-516 AC A0A024L5T5 #=GS A0A024L5T5/270-516 OS Escherichia coli #=GS A0A024L5T5/270-516 DE Cyclic-di-GMP phosphodiesterase YlaB #=GS A0A024L5T5/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A024L5T5/270-516 DR EC; 3.1.4.52; #=GS A0A454A1W7/270-516 AC A0A454A1W7 #=GS A0A454A1W7/270-516 OS Escherichia coli 536 #=GS A0A454A1W7/270-516 DE Putative diguanylate phosphodiesterase #=GS A0A454A1W7/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A200LIH0/270-516 AC A0A200LIH0 #=GS A0A200LIH0/270-516 OS Shigella sonnei #=GS A0A200LIH0/270-516 DE Cyclic diguanylate phosphodiesterase #=GS A0A200LIH0/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella sonnei; #=GS A0A2Y2T0V2/270-516 AC A0A2Y2T0V2 #=GS A0A2Y2T0V2/270-516 OS Shigella flexneri 2a #=GS A0A2Y2T0V2/270-516 DE Cyclic diguanylate phosphodiesterase (EAL) domain protein #=GS A0A2Y2T0V2/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella flexneri; #=GS A0A384LQ34/270-516 AC A0A384LQ34 #=GS A0A384LQ34/270-516 OS Shigella flexneri #=GS A0A384LQ34/270-516 DE Cyclic diguanylate phosphodiesterase #=GS A0A384LQ34/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella flexneri; #=GS A0A0H2VV38/270-516 AC A0A0H2VV38 #=GS A0A0H2VV38/270-516 OS Shigella flexneri #=GS A0A0H2VV38/270-516 DE Uncharacterized protein #=GS A0A0H2VV38/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella flexneri; #=GS A0A1Z3V5V6/270-516 AC A0A1Z3V5V6 #=GS A0A1Z3V5V6/270-516 OS Escherichia coli O157 #=GS A0A1Z3V5V6/270-516 DE EAL domain-containing protein #=GS A0A1Z3V5V6/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS Q8X578/270-516 AC Q8X578 #=GS Q8X578/270-516 OS Escherichia coli O157:H7 #=GS Q8X578/270-516 DE Membrane-anchored cyclic-di-GMP phosphodiesterase #=GS Q8X578/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A0K4ILZ9/270-516 AC A0A0K4ILZ9 #=GS A0A0K4ILZ9/270-516 OS Escherichia coli #=GS A0A0K4ILZ9/270-516 DE Cyclic diguanylate phosphodiesterase #=GS A0A0K4ILZ9/270-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A2X2I5X0/191-437 AC A0A2X2I5X0 #=GS A0A2X2I5X0/191-437 OS Shigella dysenteriae #=GS A0A2X2I5X0/191-437 DE Cyclic diguanylate phosphodiesterase (EAL) domain protein #=GS A0A2X2I5X0/191-437 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella dysenteriae; #=GS E2XBV1/191-437 AC E2XBV1 #=GS E2XBV1/191-437 OS Shigella dysenteriae 1617 #=GS E2XBV1/191-437 DE EAL domain protein #=GS E2XBV1/191-437 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella dysenteriae; #=GS A0A0K4NJJ2/272-516 AC A0A0K4NJJ2 #=GS A0A0K4NJJ2/272-516 OS Escherichia coli #=GS A0A0K4NJJ2/272-516 DE Putative signal transduction protein #=GS A0A0K4NJJ2/272-516 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli; #=GS A0A3P6KJK8/127-373 AC A0A3P6KJK8 #=GS A0A3P6KJK8/127-373 OS Shigella dysenteriae #=GS A0A3P6KJK8/127-373 DE Cyclic diguanylate phosphodiesterase (EAL) domain protein #=GS A0A3P6KJK8/127-373 DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella; Shigella dysenteriae; #=GF SQ 28 P77473/270-516 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--HYRLQDAIENHDICVHYQPIVSLSSGKIVGAEALARWPQTDGSWLSPEIFIPLSQQTGLSEPLTLLIIRSVFEDMGSWLHQHPDQHISINLESTVLTSEKIPYLLREMIHRYQVNPKQIALELTEREFADPKTSAPIIARYRQAGHDIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLNLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFIRWAEQHL A0A0E1LU23/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESPVLTSEKIPQLLRDMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A070SV60/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESPVLTSEKIPQLLRDMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A1X3JLK7/270-516 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SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESPVLTSEKIPQLLRDMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL F4SJF5/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESPVLTSEKIPQLLRDMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL M9H7C9/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESPVLTSEKIPQLLRDMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A024L5T5/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESPVLTSEKIPQLLRDMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A454A1W7/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHSQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A200LIH0/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDCLRQHPQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A2Y2T0V2/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDCLRQHPQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A384LQ34/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDCLRQHPQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A0H2VV38/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDCLRQHPQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A1Z3V5V6/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL Q8X578/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A0K4ILZ9/270-516 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL A0A2X2I5X0/191-437 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKTLPKEDFLRWAEQHL E2XBV1/191-437 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESTVLTSEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKTLPKEDFLRWAEQHL A0A0K4NJJ2/272-516 --HYRLQDAIENHDICVHYQPIVSLSSGKIVGAEALARWPQTDGSWLSPEIFIPLSQQTGLSEPLTLLIIRSVFEDMGSWLHQHPDQHISINLESTVLTSEKIPYLLREMIHRYQVNPKQIALELTEREFADPKTSAPIIARYRQAGHDIYLDDFGTGYSSLSYLQDLDVDILKIDKSFVDALEYKNVTPHIIEMAKTLNLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFIRWAEQRL A0A3P6KJK8/127-373 SPHHRLQDAIENRDICVHYQPIVSLANGKIVGAEALARWPQTDGSWLSPDSFIPLAQQTGLSEPLTLLIIRSVFEDMGDWLRQHPQQHISINLESTVLTPEKIPQLLREMINHYQVNPRQIALELTEREFADPKTSAPIISRYREAGHEIYLDDFGTGYSSLSYLQDLNVDILKIDKSFVDALEYKNVTPHIIEMAKTLKLKMVAEGIETSKQEEWLRQHGVHYGQGWLYSKALPKEDFLRWAEQHL #=GC scorecons 3397999999996999999999999669999999999999999999999759999699999999999999999999996796998699999999969998999959997996699999799999999999999999999969996999799999999999999999998999999999999999999999999999999699999999999999999999999999999999899999969999979 #=GC scorecons_70 __************************************************_***************************_******_******************_********************************************************************************************************************************************** #=GC scorecons_80 __**********_************__***********************_****_**********************_**_***_*********_********_******__***************************_***_******************************************************_***************************************_******* #=GC scorecons_90 __*_********_************__**********************__****_**********************__*_***_*********_********_***_**__*****_*********************_***_***_**************************************************_***************************************_*****_* //