# STOCKHOLM 1.0
#=GF ID 3.20.20.220/FF/000016
#=GF DE Methylenetetrahydrofolate reductase
#=GF AC 3.20.20.220/FF/000016
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 12.456
#=GS A0A0H2UP04/1-280  AC A0A0H2UP04
#=GS A0A0H2UP04/1-280  OS Streptococcus pneumoniae TIGR4
#=GS A0A0H2UP04/1-280  DE Methylenetetrahydrofolate reductase
#=GS A0A0H2UP04/1-280  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A0A1N1WZI8/1-280  AC A0A1N1WZI8
#=GS A0A1N1WZI8/1-280  OS Mycobacteroides abscessus subsp. abscessus
#=GS A0A1N1WZI8/1-280  DE Methylenetetrahydrofolate reductase
#=GS A0A1N1WZI8/1-280  DR ORG; Bacteria; Actinobacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacteroides; Mycobacteroides abscessus; Mycobacteroides abscessus subsp. abscessus; 
#=GS A0A1S0ZB97/1-285  AC A0A1S0ZB97
#=GS A0A1S0ZB97/1-285  OS Salmonella enterica subsp. enterica serovar Saintpaul
#=GS A0A1S0ZB97/1-285  DE Methylenetetrahydrofolate reductase
#=GS A0A1S0ZB97/1-285  DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella; Salmonella enterica; Salmonella enterica subsp. enterica; 
#=GS A0A096AZZ3/1-280  AC A0A096AZZ3
#=GS A0A096AZZ3/1-280  OS Peptoniphilus lacrimalis DNF00528
#=GS A0A096AZZ3/1-280  DE Methylenetetrahydrofolate reductase
#=GS A0A096AZZ3/1-280  DR ORG; Bacteria; Firmicutes; Tissierellia; Tissierellales; Peptoniphilaceae; Peptoniphilus; Peptoniphilus lacrimalis; 
#=GS A0A3R8NEV1/1-280  AC A0A3R8NEV1
#=GS A0A3R8NEV1/1-280  OS Streptococcus halitosis
#=GS A0A3R8NEV1/1-280  DE Methylenetetrahydrofolate reductase
#=GS A0A3R8NEV1/1-280  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus halitosis; 
#=GS E8KCF0/1-280      AC E8KCF0
#=GS E8KCF0/1-280      OS Streptococcus peroris ATCC 700780
#=GS E8KCF0/1-280      DE Methylenetetrahydrofolate reductase
#=GS E8KCF0/1-280      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus peroris; 
#=GS A0A3R9JXE6/1-285  AC A0A3R9JXE6
#=GS A0A3R9JXE6/1-285  OS Streptococcus sp. BCA20
#=GS A0A3R9JXE6/1-285  DE Methylenetetrahydrofolate reductase
#=GS A0A3R9JXE6/1-285  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus sp. BCA20; 
#=GS F9Q2Q3/1-285      AC F9Q2Q3
#=GS F9Q2Q3/1-285      OS Streptococcus oralis SK313
#=GS F9Q2Q3/1-285      DE Methylenetetrahydrofolate reductase
#=GS F9Q2Q3/1-285      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus oralis; 
#=GS K0ZHH2/1-285      AC K0ZHH2
#=GS K0ZHH2/1-285      OS Streptococcus sp. GMD6S
#=GS K0ZHH2/1-285      DE Methylenetetrahydrofolate reductase
#=GS K0ZHH2/1-285      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus sp. GMD6S; 
#=GS F9PTZ3/1-280      AC F9PTZ3
#=GS F9PTZ3/1-280      OS Streptococcus infantis SK970
#=GS F9PTZ3/1-280      DE Methylenetetrahydrofolate reductase
#=GS F9PTZ3/1-280      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus infantis; 
#=GS A0A1X1FQM2/1-285  AC A0A1X1FQM2
#=GS A0A1X1FQM2/1-285  OS Streptococcus oralis subsp. tigurinus
#=GS A0A1X1FQM2/1-285  DE Methylenetetrahydrofolate reductase
#=GS A0A1X1FQM2/1-285  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus oralis; Streptococcus oralis subsp. tigurinus; 
#=GS A0A1X1H732/1-285  AC A0A1X1H732
#=GS A0A1X1H732/1-285  OS Streptococcus oralis subsp. oralis
#=GS A0A1X1H732/1-285  DE Methylenetetrahydrofolate reductase
#=GS A0A1X1H732/1-285  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus oralis; Streptococcus oralis subsp. oralis; 
#=GS A5M6L0/2-280      AC A5M6L0
#=GS A5M6L0/2-280      OS Streptococcus pneumoniae SP14-BS69
#=GS A5M6L0/2-280      DE Methylenetetrahydrofolate reductase
#=GS A5M6L0/2-280      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A0A0U0MDK6/2-280  AC A0A0U0MDK6
#=GS A0A0U0MDK6/2-280  OS Streptococcus pneumoniae
#=GS A0A0U0MDK6/2-280  DE Methylenetetrahydrofolate reductase
#=GS A0A0U0MDK6/2-280  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A0A0I8WPU2/1-280  AC A0A0I8WPU2
#=GS A0A0I8WPU2/1-280  OS Streptococcus pneumoniae
#=GS A0A0I8WPU2/1-280  DE Methylenetetrahydrofolate reductase
#=GS A0A0I8WPU2/1-280  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS J1NZ88/1-280      AC J1NZ88
#=GS J1NZ88/1-280      OS Streptococcus pneumoniae 2070335
#=GS J1NZ88/1-280      DE Methylenetetrahydrofolate reductase
#=GS J1NZ88/1-280      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A0A139PJH9/1-285  AC A0A139PJH9
#=GS A0A139PJH9/1-285  OS Streptococcus oralis
#=GS A0A139PJH9/1-285  DE Methylenetetrahydrofolate reductase
#=GS A0A139PJH9/1-285  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus oralis; 
#=GS Q8DQT1/1-285      AC Q8DQT1
#=GS Q8DQT1/1-285      OS Streptococcus pneumoniae R6
#=GS Q8DQT1/1-285      DE Methylenetetrahydrofolate reductase
#=GS Q8DQT1/1-285      DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A0A0H2ZP69/1-285  AC A0A0H2ZP69
#=GS A0A0H2ZP69/1-285  OS Streptococcus pneumoniae D39
#=GS A0A0H2ZP69/1-285  DE Methylenetetrahydrofolate reductase
#=GS A0A0H2ZP69/1-285  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A0A2U3RYI5/1-285  AC A0A2U3RYI5
#=GS A0A2U3RYI5/1-285  OS Streptococcus pneumoniae
#=GS A0A2U3RYI5/1-285  DE Methylenetetrahydrofolate reductase
#=GS A0A2U3RYI5/1-285  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GS A0A0E9GLJ0/1-280  AC A0A0E9GLJ0
#=GS A0A0E9GLJ0/1-280  OS Streptococcus pneumoniae
#=GS A0A0E9GLJ0/1-280  DE Methylenetetrahydrofolate reductase
#=GS A0A0E9GLJ0/1-280  DR ORG; Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus pneumoniae; 
#=GF SQ 21
A0A0H2UP04/1-280          MSRQTPSLSFEVFPPNPAVGNDNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHA-----
A0A1N1WZI8/1-280          MSRQTPSLSFEVFPPNPEVGNDKIIAALKDMQGLAPHFISVTASNNKFNIKETTVRLADYIQNDLEIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPGVEPQKDFRYATDLIEFIKEQAPHFDIVGACYPEGHPDSPNQISDIQNLKRKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYENDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAQYIHQATHA-----
A0A1S0ZB97/1-285          MSRQTPSLSFEVFPPNPAVGNDKIISALQDMRELTPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETAKYIHQATHALFNHQ
A0A096AZZ3/1-280          MSRQTPSLSFEVFPPNPEVGNDKIIAALKDMQGLAPHFISVTASNNKFNIKETTVRLADYIQNDLEIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPGVEPQKDFRYATDLIEFITEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYENDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAQYIHQATHA-----
A0A3R8NEV1/1-280          MSRQTPSLSFEVFPPNPAVGNDKIISALQDMRELTPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIISDVEPQKDFRYATDLIEFIKEQAPHFEIVGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETAKYIHQATHA-----
E8KCF0/1-280              MSRQTPSLSFEVFPPNPEVGNDKIIAALKDMQGLAPHFISVTASNNKFNIKETTVRLADYIQNDLEIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPGVEPQKDFRYATDLIEFIKEQAPHFDIVGACYPEGHPDSPNQISDIQNLKRKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYENDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAQYIHQATHA-----
A0A3R9JXE6/1-285          MSRQTPSLSFEVFPPNPAVGNDKIISALQDMRELTPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETAKYIHQATHALFNHQ
F9Q2Q3/1-285              MSRQTPSLSFEVFPPNPAVGNDKIISALQDMRELTPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETAKYIHQATHALFNHQ
K0ZHH2/1-285              MSRQTPSLSFEVFPPNPAVGNDKIISALQDMRELTPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETAKYIHQATHALFNHQ
F9PTZ3/1-280              MSRQTPSLSFEVFPPNPSVGNDKIIAALKDMQGLAPHFISVTASNNKFNIKETTVRLADYIQNDLEIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPGVEPQKDFRYATDLIEFINEQAPHFDIIGACYPEGHPDSPNQISDIQNLKRKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYENDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAQYIHQATHA-----
A0A1X1FQM2/1-285          MSRQTPSLSFEVFPPNPAVGNDKIISALQDMRELTPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETAKYIHQATHALFNHQ
A0A1X1H732/1-285          MSRQTPSLSFEVFPPNPAVGNDKIISALQDMRELTPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETAKYIHQATHALFNHQ
A5M6L0/2-280              -SCQTPSLSFEVFPPNPAVGNDNIILALQDMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHA-----
A0A0U0MDK6/2-280          -SCQTPSLSFEVFPPNPAVGNDNIILALQDMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHA-----
A0A0I8WPU2/1-280          MSRQTPSLSFEVFPPNPAVGNGNIISALQYMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHA-----
J1NZ88/1-280              MSRQTPSLSFEVFPPNPAVGNGNIISALQYMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHA-----
A0A139PJH9/1-285          MSRQTPSLSFEVFPPNPAVGNDKIISALQDMRELTPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETAKYIHQATHALFNHQ
Q8DQT1/1-285              MSRQTPSLSFEVFPPTPAVGNDNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIELIKERAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDIAGVHLYTMNNADTAKYIHQATHALFNHQ
A0A0H2ZP69/1-285          MSRQTPSLSFEVFPPTPAVGNDNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIELIKERAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDIAGVHLYTMNNADTAKYIHQATHALFNHQ
A0A2U3RYI5/1-285          MSRQTPSLSFEVFPPTPAVGNDNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIELIKERAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDIAGVHLYTMNNADTAKYIHQATHALFNHQ
A0A0E9GLJ0/1-280          MSRQTPSLSFEVFPPNPAVGNDNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHA-----
#=GC scorecons            797999999999999796999869959977966969999999999999999999999997999996999999999999999999999999999999999999999986999999999999999797977999897999999999999999999999979999999999999999999999999996999999999999999999999999999999999999999999999699999999999999999999999989999999999979979999999911111
#=GC scorecons_70         **********************_**_***************************************************************************************************************************************************************_**********************************************************************************************_____
#=GC scorecons_80         *****************_****_**_**_**__*_******************************_*****************************************_*****************************************************************************_*********************************************_***************************************_********_____
#=GC scorecons_90         _*_************_*_***__**_**__*__*_************************_*****_*****************************************_***************_*_*__*****_**********************_***************************_*********************************************_************************_***********_**_********_____
//