# STOCKHOLM 1.0 #=GF ID 3.10.20.770/FF/000005 #=GF DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit #=GF AC 3.10.20.770/FF/000005 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 95.720 #=GS 5fi4A01/1-327 AC P42336 #=GS 5fi4A01/1-327 OS Homo sapiens #=GS 5fi4A01/1-327 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform #=GS 5fi4A01/1-327 DR CATH; 5fi4; A:2-327; #=GS 5fi4A01/1-327 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS P91634/27-336 AC P91634 #=GS P91634/27-336 OS Drosophila melanogaster #=GS P91634/27-336 DE PI-3 kinase #=GS P91634/27-336 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; #=GS P91634/27-336 DR GO; GO:0002164; GO:0002168; GO:0005829; GO:0005943; GO:0005975; GO:0006629; GO:0006914; GO:0006979; GO:0007346; GO:0007390; GO:0007436; GO:0007552; GO:0008286; GO:0008361; GO:0009267; GO:0010507; GO:0010884; GO:0014065; GO:0016303; GO:0030307; GO:0030536; GO:0030707; GO:0035004; GO:0035005; GO:0035099; GO:0035212; GO:0035264; GO:0036099; GO:0036335; GO:0040014; GO:0042127; GO:0042593; GO:0045572; GO:0045727; GO:0045793; GO:0045887; GO:0046622; GO:0046854; GO:0046934; GO:0048010; GO:0048167; GO:0048169; GO:0048477; GO:0048813; GO:0050773; GO:0051823; GO:0051897; GO:0055088; GO:0055115; GO:0060074; GO:0071902; GO:1904263; GO:1904801; GO:2000252; GO:2000377; #=GS 5dxhD01/1-326 AC P42336 #=GS 5dxhD01/1-326 OS Homo sapiens #=GS 5dxhD01/1-326 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform #=GS 5dxhD01/1-326 DR CATH; 5dxh; D:2-327; #=GS 5dxhD01/1-326 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS 5dxhA01/1-326 AC P42336 #=GS 5dxhA01/1-326 OS Homo sapiens #=GS 5dxhA01/1-326 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform #=GS 5dxhA01/1-326 DR CATH; 5dxh; A:2-327; #=GS 5dxhA01/1-326 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS 4wafA01/1-326 AC P42336 #=GS 4wafA01/1-326 OS Homo sapiens #=GS 4wafA01/1-326 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform #=GS 4wafA01/1-326 DR CATH; 4waf; A:2-327; #=GS 4wafA01/1-326 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS 4l2yA01/1-327 AC P42336 #=GS 4l2yA01/1-327 OS Homo sapiens #=GS 4l2yA01/1-327 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform #=GS 4l2yA01/1-327 DR CATH; 4l2y; A:8-327; #=GS 4l2yA01/1-327 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS 4l23A01/1-327 AC P42336 #=GS 4l23A01/1-327 OS Homo sapiens #=GS 4l23A01/1-327 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform #=GS 4l23A01/1-327 DR CATH; 4l23; A:8-327; #=GS 4l23A01/1-327 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS 4l1bA01/1-327 AC P42336 #=GS 4l1bA01/1-327 OS Homo sapiens #=GS 4l1bA01/1-327 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform #=GS 4l1bA01/1-327 DR CATH; 4l1b; A:8-327; #=GS 4l1bA01/1-327 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS 4jpsA01/1-327 AC P42336 #=GS 4jpsA01/1-327 OS Homo sapiens #=GS 4jpsA01/1-327 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform #=GS 4jpsA01/1-327 DR CATH; 4jps; A:2-327; #=GS 4jpsA01/1-327 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS 4a55A01/33-355 AC P42337 #=GS 4a55A01/33-355 OS Mus musculus #=GS 4a55A01/33-355 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform #=GS 4a55A01/33-355 DR CATH; 4a55; A:5-327; #=GS 4a55A01/33-355 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Mus; Mus; Mus musculus; #=GS B3RZJ1/1-303 AC B3RZJ1 #=GS B3RZJ1/1-303 OS Trichoplax adhaerens #=GS B3RZJ1/1-303 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit #=GS B3RZJ1/1-303 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS Q7QEJ7/51-352 AC Q7QEJ7 #=GS Q7QEJ7/51-352 OS Anopheles gambiae #=GS Q7QEJ7/51-352 DE AGAP000018-PA #=GS Q7QEJ7/51-352 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles gambiae; #=GS T1G9A0/1-270 AC T1G9A0 #=GS T1G9A0/1-270 OS Helobdella robusta #=GS T1G9A0/1-270 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit #=GS T1G9A0/1-270 DR ORG; Eukaryota; Metazoa; Annelida; Clitellata; Hirudinea; Hirudinida; Glossiphoniiformes; Glossiphoniidae; Helobdella; Helobdella robusta; #=GS E9HU25/3-316 AC E9HU25 #=GS E9HU25/3-316 OS Daphnia pulex #=GS E9HU25/3-316 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit #=GS E9HU25/3-316 DR ORG; Eukaryota; Metazoa; Arthropoda; Crustacea; Branchiopoda; Phyllopoda; Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia; Daphnia pulex; #=GS D6X2N9/10-321 AC D6X2N9 #=GS D6X2N9/10-321 OS Tribolium castaneum #=GS D6X2N9/10-321 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit #=GS D6X2N9/10-321 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga; Cucujiformia; Tenebrionoidea; Tenebrionidae; Tribolium; Tribolium castaneum; #=GS T1ELN4/1-329 AC T1ELN4 #=GS T1ELN4/1-329 OS Helobdella robusta #=GS T1ELN4/1-329 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit #=GS T1ELN4/1-329 DR ORG; Eukaryota; Metazoa; Annelida; Clitellata; Hirudinea; Hirudinida; Glossiphoniiformes; Glossiphoniidae; Helobdella; Helobdella robusta; #=GS A7S2J3/2-316 AC A7S2J3 #=GS A7S2J3/2-316 OS Nematostella vectensis #=GS A7S2J3/2-316 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit #=GS A7S2J3/2-316 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A9UWS0/2-301 AC A9UWS0 #=GS A9UWS0/2-301 OS Monosiga brevicollis #=GS A9UWS0/2-301 DE PI3K-CA alpha #=GS A9UWS0/2-301 DR ORG; Eukaryota; Choanoflagellida; Salpingoecidae; Monosiga; Monosiga brevicollis; #=GS C3YMZ3/2-321 AC C3YMZ3 #=GS C3YMZ3/2-321 OS Branchiostoma floridae #=GS C3YMZ3/2-321 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit #=GS C3YMZ3/2-321 DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma floridae; #=GS B4QS08/27-330 AC B4QS08 #=GS B4QS08/27-330 OS Drosophila simulans #=GS B4QS08/27-330 DE GD20048 #=GS B4QS08/27-330 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila simulans; #=GS B4II96/27-339 AC B4II96 #=GS B4II96/27-339 OS Drosophila sechellia #=GS B4II96/27-339 DE GM23175 #=GS B4II96/27-339 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila sechellia; #=GS B3P349/25-337 AC B3P349 #=GS B3P349/25-337 OS Drosophila erecta #=GS B3P349/25-337 DE GG15290 #=GS B3P349/25-337 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila erecta; #=GS B4PPQ8/27-338 AC B4PPQ8 #=GS B4PPQ8/27-338 OS Drosophila yakuba #=GS B4PPQ8/27-338 DE Uncharacterized protein, isoform A #=GS B4PPQ8/27-338 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila yakuba; #=GS C3XYJ1/2-308 AC C3XYJ1 #=GS C3XYJ1/2-308 OS Branchiostoma floridae #=GS C3XYJ1/2-308 DE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit #=GS C3XYJ1/2-308 DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma floridae; #=GF SQ 24 5fi4A01/1-327 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECL--REATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNRE------EKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPEL-PKHIYNKLDKGQ--IIVVIWVIVSPNNDKQK------YTLKINHDCVPEQVIAEAIRKKTRSKKLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPN--------LMLMAKESLYSQLPMDCFTMPSY-------SRRISTATPYMNGETSTKSL---- P91634/27-336 PPCMRFSVNLWKNE-MLNWVDLICLLPNGFLLELRVN--PANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGIS----TFNIEPYTDETKRLSEVQPYFGILSLGERTDTTS-FSS--DYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKM-PELIRERHPTRT------FLIVVKNENDQST------FTLSVNEQDTPFSLTESTLQKMNRSQM--------KMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPN--------VVLQSVYRLESYINHHNE--------------QAMVTKRPLPKKRTVHLHK--- 5dxhD01/1-326 -PPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECL--REATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNRE------EKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPEL-PKHIYNKLDKGQ--IIVVIWVIVSPNNDKQK------YTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPN--------LMLMAKESLYSQLPMDCFTMPSY-------SRRISTATPYMNGETSTKSL---- 5dxhA01/1-326 -PPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECL--REATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNRE------EKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPEL-PKHIYNKLDKGQ--IIVVIWVIVSPNNDKQK------YTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPN--------LMLMAKESLYSQLPMDCFTMPSY-------SRRISTATPYMNGETSTKSL---- 4wafA01/1-326 -PPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECL--REATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNRE------EKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPEL-PKHIYNKLDKGQ--IIVVIWVIVSPNNDKQK------YTLKINHDCVPEQVIAEAIRKKTRSKKLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPN--------LMLMAKESLYSQLPMDCFTMPSY-------SRRISTATPYMNGETSTKSL---- 4l2yA01/1-327 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECL--REATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNRE------EKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPEL-PKHIYNKLDKGQ--IIVVIWVIVSPNNDKQK------YTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPN--------LMLMAKESLYSQLPMDCFTMPSY-------SRRISTATPYMNGETSTKSL---- 4l23A01/1-327 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECL--REATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNRE------EKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPEL-PKHIYNKLDKGQ--IIVVIWVIVSPNNDKQK------YTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPN--------LMLMAKESLYSQLPMDCFTMPSY-------SRRISTATPYMNGETSTKSL---- 4l1bA01/1-327 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECL--REATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNRE------EKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPEL-PKHIYNKLDKGQ--IIVVIWVIVSPNNDKQK------YTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPN--------LMLMAKESLYSQLPMDCFTMPSY-------SRRISTATPYMNGETSTKSL---- 4jpsA01/1-327 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECL--REATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ---EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNRE------EKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPEL-PKHIYNKLDKGQ--IIVVIWVIVSPNNDKQK------YTLKINHDCVPEQVIAEAIRKKTRSKKLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPN--------LMLMAKESLYSQLPMDCFTMPSY-------SRRISTATPYMNGETSTKSL---- 4a55A01/33-355 ----PSSGELWGIHLMPPRILVECLLPNGMIVTLECL--REATLVTIKHELFREARKYPLHQLLQDETSYIFVSVTQ---EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNRE------EKILNREIGFVIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPEL-PKHIYNKLDKGQ--IIVVIWVIVSPNNDKQK------YTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPN--------LMLMAKESLYSQLPIDSFTMPSY-------SRRISTATPYMNGETSTKSL---- B3RZJ1/1-303 -----------------MSLAIDFLLPTGLMITLEFS--KSITISQMKQQVWERAAAMPFGELMFECPSYHLMFINH---RGEREEMTDESRRLSDIRPFAAIFKFVERVGVPP------EKRLDQQIAELIECKLDLSEIPLKVEIEDCHQSLQELCHEVVTRRANSSEEDRANYLYRPPMSLS-QL-PSYLEERYEKKGG-----ILITVLYQSDDRIDDGCNKHTTSVPHNQTASFVVRQVLKAKAKKGQGN------VHQEDYNSYVLKICGRNEYLISEVPIHQYKFIRLAMIRDESPI--------VVLQKRLKLKLKECDLPN--------------EAYTPPPLPKKIDIQTKTVWDI Q7QEJ7/51-352 P---RFDYGFWKNP--DESTELIFLMPNGVMITMYIP--IHITLDELKSDVWEEAERYPLYCHLGDKNKYCFGTLAAGRTNSNTTYENEAETRLMDVQPTLGILRFVEKSNVSE------NTKLMENISSLLDSKL-PVKTLVNPEVNDFRAKMSMLSEDIGSRRAVMTRMERIAYQYPAKLVSGAHV-PEPISRRLTNGD-------FCVVAISTDMQ-------LTVKVPCRATPDEVLKRILKKQNPSKA--------RNENSSTEYILKVCGREEYIYGAHPMISFQYVQDCLSRDETPT--------FVPRLVRTVEVFKNDIYDAREDFTQ----WSASAKPSSL--------------- T1G9A0/1-270 -------------------MSFQFLLPSGFLVDMKVQ--KNATIAAVKRDLWREMKTHPYYGYLGSLECYYFICIDE---TSNKIEITDETRRLCDVRPFYPMFKL-EKLNDQVAGTENFERVLDARITVLIGKSLKDLDEITEPEVVEFRSKMSSMYVELLQ-----DWLEQVTRYHPPDLVPVNKL-PDLIEDILAQNKE-I---IVVSVHVEDEETS-------KIRVKYNITPKQLIDTFFEKKSKQ----------NLNWSAGDYVLKVLGLQEYLLGDYPLHQFAHIRSSLIKETVPE--------LVLVHYQSIPRESYPNCL------------------------------------ E9HU25/3-316 -----------ANPSQDAKITINCLMPNSILIPLDVI--SNAVLSELKEELWEEARKYPLQGLLKEQSSYNFMCVNC---MAERETLIDESRRLCDVKPFYNLLKVVEREGDKA------EETLNTKIGQLIGKGLHDFDSLKSLEVNEFRWRMKDMVSAISREREDTSTLDRIKQQYPCDMADSDDL-PAYLAPKLRDGV------MQVNIQLENMETC------FSFSIAHTSTPFQLTTMALQRNAHLLGQYP-----IEEDIGCGHVLKVSGRQEYLIGDFPLSRFLYVRNTLTREEHPS--------FVVVASQSVILESVSTMSSALSSAQEAEAVKRNSRNSFPTMRKKQSLLSW---- D6X2N9/10-321 PFPREYSPDFWSFD-PEDSVELTCLMPNGIVILLKVS--YNATLLDIKADLWEEAPKYPLHGKLHDMSSYVFTCINS---MAEREELHDETRRICDVKPTCAVLKI-ECLGNEP------DNKINVQIGHLIGRSVKEFDELNNPEINDFRFQMRKLGDDITQKRLKYTWLEKLYYQFPPRLCPKSKIFPETLDQKKN---------IKITTRFEDNENS------FTFNVSPYIYPNKLLEMILAKRSNVLK--------IRYDRCNDYVLKVCGQDEYLVGDHQLIQFQYIQDSLSTDVTPI--------VVTVRVNKVPVTPDNPYESLDNFDH----RRMRSTYSTLTWRKRAHKS------ T1ELN4/1-329 MAPRPSSGELWGHHLMPAEVEVLFFMPNGMFISMRAN--RDASLQTIKSNLWKEVKMYPLYKKLMEPQCYVLVGVTQ---DAEREEFYDETRRLCDLRLFQPMFKLIEPAGNKE------EKILNAKLNFLIGVSINEINDSKDLELLNFRRSIMQHCKSVIEERDSKGIEALALYHYPPNINPTLQL-PAFLLDVVKRDLGRIIVTVWVDVHLSKSRSK------TTIKVHYDSPVMSVISETVRRKVKLEKVLPEDMESVISSRAANSLLKVCGCDEYLLGNYPICQYAYVRQTLSTHSIPE--------LMLVDKKSVYSTLTRHVVNMPSY-------IQKGLSQMESLKNQQPVSSW---- A7S2J3/2-316 AP--VSRLDMWASLSACTPVDVDCLLPTGVLIPIEVR--IEATLGEIKNKLWREAASYPLFNLLKEMSSYVFVCVNL---QGKQEELVDENRQLIDVRPFRPMLKLIEKKGDRE------EKLLSSKISVLIGKNLHEFDQMKNPEVDEFRRRYAEYVEGIAKERSKLDWEGRAMYAYPVEIEQSEET-PAYVAQKLNENRR-----FLISVAIRNNRAS--MKDMHAFNVSADTFPEELLVLVLKKRGAIMGV-------QDFDNPKDYVLKIVGRESYLLGEYSLLRYRYISECIAQGKRPQ--------LSLVRRVSLGVNELMDVSGKSGI---------QHRPPPPLPPKVESAE------ A9UWS0/2-301 -------------------ESVICLLPTGMIVKLDVAIGGSQTYNDIKNNVWQAASGLPFFHELKQPQSYGFSAVGT---DGEMLELHDDD-LFDRTRLYTPWLKVCSR-GSKE------EQRFNLDISRLIGKQLSEFDFIRDPEVVAFRQSILSICQNAQKLRQSEGIEGAALHRFPPNTISS-PF-PQHLKAKLNKKEQ-----FILMVYFSSDQAS-------KTVCDINQTPDELIKVIVRKGRVGQK--------LGSDNPTEYVLKVHGRDEYLLGKFRMGDYKYVRHCLAHGYTKTDLSDHNCRLVLERRDDMYKKIPQANTDKMLMSK----SALRLEEPTPANPAQ---------- C3YMZ3/2-321 P---PSSGELWGMHLMPPKVPVDCLLPTGIMITLDVP--REATLEHIKGDLWREARKYPLFHKLQDETMYIFISITQ---EAEKEEFYDETRRFCDLRLFQPWLKVTEPRGNRE------EKILNSEISLAISMPVTEFGTVKDPEVIDFRRNILTTCLQSVQERDQDGQSGQSLYVYPPIIETDPSL-PKNLDAKLDIGH--IIVTIWVL-TRENERQK------YTVKVSKSSLPEDVIAGAIKKKTRTMGLTPEQQQQCIEGYQSSYVLKVCGAEEYMLGRYPIIQYKYIRMCLSRSRFPN--------LMLMSKEGVYASLPESTFHLPSY-------ARRGSSAVLNPSNGTAQ------- B4QS08/27-330 PPCMRFSVNLWKNE-MLNWVDLICLL---------VN--PANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGIS----TFNIEPYTDETKRLSEVQPYFGILSLGERTDTTS-FSS--DYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSVYTWQQRLLYEHPLRLANSTKM-PELIRERHPTRT------FLIVVKNENDQST------FTLSVNEQDTPFSLTESTLQKMNRSQM--------KMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPN--------VVLQSVYRLESYINHHNE--------------QAMVTKRLPPKKQTVHPQKAIS B4II96/27-339 PPCMRFSVNLWKNE-MLNWVDLICLLPNGFLIELRVN--PANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGIS----TFNIEPYTDETKRLSEVQPYFGILSLGERTDTTS-FSS--DYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSVYTWQQRLLYEHPLRLANSTKM-PELIRERHPTRT------FLIVVKNENDQST------FTLSVNEQDTPFSLTESTLQKMNRSQM--------KMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPN--------VVLQSVYRLESYINHHNE--------------QAMVTKRLPPKKQTVHPQKAIS B3P349/25-337 SPCMRFSVNLWKNE-MLDWVDLICLLPNGFLLELRVN--PANTIQVIKVEMVNQAKQMPLSYMIKDACEYQVYGIS----TFNIEPYTDETKRLSEVQPYFGLLSLGERTDTAS-FSS--DYELTKMVSGMIGATFDHHRTNGSPEIDDFRLYMTQTCDNIELERSIYTWQQRLLYEHPLRLANSPKM-PELIRERHPTRT------FLIVVKNENDQST------FTLSVNEQDTPFSLTESTLQKMNRSQM--------KMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQETLSDSAVPN--------VVLQSVYRLESYINHHNE--------------QAMVPKRPPPKKQPTPLQKALP B4PPQ8/27-338 PPCMRFSVNLWKNE-MLDWVDLICLLPNGFLLELRVN--PAITIQVIKVEMVNQAKQMPLSYVIKEACEYQVYGIS----TFNIEPYTDETKRLSEVQPYFGLLSLGERTDTTS-FSS--DYELTKMVSGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSVYTWQQRLLYEHPLRLANSTKM-PELIRERHPTRT------FLIVVKNENDQST------FTLSVNEQDTPFSLTESTLQKMNRSQM--------KMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQETLSDSAVPN--------VVLQSVYRLESYINHHNE--------------QAMAPKRPPPKKQPTLLPKAL- C3XYJ1/2-308 PPVEAFMLDIWAKEADSPTIQVDCLLPTGIYIPLTCS--RDATIEQIKRDLWQEARTYPLYSELAEVQSYVFMCINQ---TAEQEELHEEQRRLCDVRPFRPILKLVQKKKDPAA----VEKLLNSQISVLIGKGLHEFDSMKDPEVDEFRGRMRQMVRDIADSRKEKSWVERLQYQFPPRLESSEDL-PKHMQPANNN--------LVVNIRFHNTDMS------YSFQVHVMAFPIELHQLALKKKASFLR--------QPEEDPADFTLKVCGQFDYLIGEFPISRFKYVRKCLSKATTPQ--------LMLVNLDNIDLEPVTSPT------------TPDPEGPPPLPCKQEKM------- #=GC scorecons 231123423453231323253536878574453644300345763379366446754597433646344936346420004464654387567757565635476537435444000000743853374258734535453345797368833634454453338323433464473685454463450944634543332001110436473346544300000046546434347346533455744543211110000333533447699859458966646764674876346434348400000000667433346343333333111220000000114333434233333322210000 #=GC scorecons_70 _______________________****_*____*________*___**__*___*___**___*_____*____*_________*___**__**_*_*_*___**__*____________*__*___*___**___________***_***_____________*_______*__*_**_____*____*__*________________*_*_______________*__*_____*__*______*______________________*****_*__****__***_**_***__*_____*___________*___________________________________________________ #=GC scorecons_80 ________________________***_*_____________*___**______*___**_________*__________________**__**_________*___*_______________*___*___**___________**___**_____________*__________*__*__________*______________________________________________*_________*______________________*_***_*__**_____*___*_**_________*___________*___________________________________________________ #=GC scorecons_90 ________________________*_*____________________*__________*__________*__________________*__________________________________________*_____________*___**___________________________*__________*_________________________________________________________________________________***_*___*___________*__________*_______________________________________________________________ //