# STOCKHOLM 1.0
#=GF ID 2.60.120.820/FF/000005
#=GF DE Highwire, isoform B
#=GF AC 2.60.120.820/FF/000005
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 41.009
#=GS Q9NB71/2012-2178      AC Q9NB71
#=GS Q9NB71/2012-2178      OS Drosophila melanogaster
#=GS Q9NB71/2012-2178      DE E3 ubiquitin-protein ligase highwire
#=GS Q9NB71/2012-2178      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; 
#=GS Q9NB71/2012-2178      DR GO; GO:0004842; GO:0005515; GO:0005886; GO:0006914; GO:0007616; GO:0007628; GO:0008270; GO:0008582; GO:0010629; GO:0016567; GO:0030514; GO:0031410; GO:0040011; GO:0045886; GO:0048678; GO:0050808; GO:2000331; 
#=GS X2JF19/2012-2178      AC X2JF19
#=GS X2JF19/2012-2178      OS Drosophila melanogaster
#=GS X2JF19/2012-2178      DE Highwire, isoform B
#=GS X2JF19/2012-2178      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; 
#=GS A7US37/1670-1836      AC A7US37
#=GS A7US37/1670-1836      OS Anopheles gambiae
#=GS A7US37/1670-1836      DE AGAP011177-PA
#=GS A7US37/1670-1836      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles gambiae; 
#=GS A0A084VHV7/610-777    AC A0A084VHV7
#=GS A0A084VHV7/610-777    OS Anopheles sinensis
#=GS A0A084VHV7/610-777    DE Uncharacterized protein
#=GS A0A084VHV7/610-777    DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Anopheles; Laticorn; Myzorhynchus; hyrcanus group; Anopheles sinensis; 
#=GS A0A182FKJ0/1897-2067  AC A0A182FKJ0
#=GS A0A182FKJ0/1897-2067  OS Anopheles albimanus
#=GS A0A182FKJ0/1897-2067  DE Uncharacterized protein
#=GS A0A182FKJ0/1897-2067  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Nyssorhynchus; Anopheles albimanus; 
#=GS A0A182YB43/897-1064   AC A0A182YB43
#=GS A0A182YB43/897-1064   OS Anopheles stephensi
#=GS A0A182YB43/897-1064   DE Uncharacterized protein
#=GS A0A182YB43/897-1064   DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles stephensi; 
#=GS A0A182J9U7/888-1054   AC A0A182J9U7
#=GS A0A182J9U7/888-1054   OS Anopheles atroparvus
#=GS A0A182J9U7/888-1054   DE Uncharacterized protein
#=GS A0A182J9U7/888-1054   DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Anopheles; Angusticorn; Anopheles; maculipennis group; Anopheles atroparvus; 
#=GS A0A182NZK4/493-660    AC A0A182NZK4
#=GS A0A182NZK4/493-660    OS Anopheles epiroticus
#=GS A0A182NZK4/493-660    DE Uncharacterized protein
#=GS A0A182NZK4/493-660    DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles epiroticus; 
#=GS A0A182RTE7/1807-1974  AC A0A182RTE7
#=GS A0A182RTE7/1807-1974  OS Anopheles funestus
#=GS A0A182RTE7/1807-1974  DE Uncharacterized protein
#=GS A0A182RTE7/1807-1974  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; funestus group; funestus subgroup; Anopheles funestus; 
#=GS A0A182JNI9/1901-2067  AC A0A182JNI9
#=GS A0A182JNI9/1901-2067  OS Anopheles christyi
#=GS A0A182JNI9/1901-2067  DE Uncharacterized protein
#=GS A0A182JNI9/1901-2067  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles christyi; 
#=GS A0A182LV69/1796-1963  AC A0A182LV69
#=GS A0A182LV69/1796-1963  OS Anopheles culicifacies
#=GS A0A182LV69/1796-1963  DE Uncharacterized protein
#=GS A0A182LV69/1796-1963  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles culicifacies; 
#=GS A0A182N2D3/1813-1979  AC A0A182N2D3
#=GS A0A182N2D3/1813-1979  OS Anopheles dirus
#=GS A0A182N2D3/1813-1979  DE Uncharacterized protein
#=GS A0A182N2D3/1813-1979  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; leucosphyrus group; leucosphyrus subgroup; Anopheles dirus; 
#=GS A0A182S7T2/1235-1402  AC A0A182S7T2
#=GS A0A182S7T2/1235-1402  OS Anopheles maculatus
#=GS A0A182S7T2/1235-1402  DE Uncharacterized protein
#=GS A0A182S7T2/1235-1402  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles maculatus group; Anopheles maculatus; 
#=GS A0A182UVE3/1839-2005  AC A0A182UVE3
#=GS A0A182UVE3/1839-2005  OS Anopheles merus
#=GS A0A182UVE3/1839-2005  DE Uncharacterized protein
#=GS A0A182UVE3/1839-2005  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles merus; 
#=GS A0A182WDH1/1766-1933  AC A0A182WDH1
#=GS A0A182WDH1/1766-1933  OS Anopheles minimus
#=GS A0A182WDH1/1766-1933  DE Uncharacterized protein
#=GS A0A182WDH1/1766-1933  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; minimus group; Anopheles minimus; 
#=GS A0A182TRI3/1900-2066  AC A0A182TRI3
#=GS A0A182TRI3/1900-2066  OS Anopheles melas
#=GS A0A182TRI3/1900-2066  DE Uncharacterized protein
#=GS A0A182TRI3/1900-2066  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles melas; 
#=GS A0A182KL56/1898-2064  AC A0A182KL56
#=GS A0A182KL56/1898-2064  OS Anopheles coluzzii
#=GS A0A182KL56/1898-2064  DE Uncharacterized protein
#=GS A0A182KL56/1898-2064  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles coluzzii; 
#=GS A0A182QJF9/856-1023   AC A0A182QJF9
#=GS A0A182QJF9/856-1023   OS Anopheles farauti
#=GS A0A182QJF9/856-1023   DE Uncharacterized protein
#=GS A0A182QJF9/856-1023   DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles farauti; 
#=GS A0A0P9BQK0/302-466    AC A0A0P9BQK0
#=GS A0A0P9BQK0/302-466    OS Drosophila ananassae
#=GS A0A0P9BQK0/302-466    DE Uncharacterized protein
#=GS A0A0P9BQK0/302-466    DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; ananassae subgroup; Drosophila ananassae; 
#=GS A0A1W4VFP9/2022-2188  AC A0A1W4VFP9
#=GS A0A1W4VFP9/2022-2188  OS Drosophila ficusphila
#=GS A0A1W4VFP9/2022-2188  DE E3 ubiquitin-protein ligase highwire
#=GS A0A1W4VFP9/2022-2188  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; ficusphila subgroup; Drosophila ficusphila; 
#=GS B3NUW1/2016-2180      AC B3NUW1
#=GS B3NUW1/2016-2180      OS Drosophila erecta
#=GS B3NUW1/2016-2180      DE Uncharacterized protein
#=GS B3NUW1/2016-2180      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila erecta; 
#=GS A0A0R1EE00/1937-2103  AC A0A0R1EE00
#=GS A0A0R1EE00/1937-2103  OS Drosophila yakuba
#=GS A0A0R1EE00/1937-2103  DE Uncharacterized protein
#=GS A0A0R1EE00/1937-2103  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila yakuba; 
#=GS B4IJ87/2012-2178      AC B4IJ87
#=GS B4IJ87/2012-2178      OS Drosophila sechellia
#=GS B4IJ87/2012-2178      DE GM12011
#=GS B4IJ87/2012-2178      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila sechellia; 
#=GF SQ 23
Q9NB71/2012-2178              TGARFARCDVSRTWNTGNFGPDAIAFAVDRPGVAIAGAMVYSGSGSYDYQLELLYDNTADLQPQ------HKWETLESVSGSYDQDAVHNDLAEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGA-QFHFYACDLSFNGTTPARGQLPCILYYSTPMKQDGHS
X2JF19/2012-2178              TGARFARCDVSRTWNTGNFGPDAIAFAVDRPGVAIAGAMVYSGSGSYDYQLELLYDNTADLQPQ------HKWETLESVSGSYDQDAVHNDLAEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGA-QFHFYACDLSFNGTTPARGQLPCILYYSTPMKQDGHS
A7US37/1670-1836              TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRAGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPARGQIPAILYYCTPV------
A0A084VHV7/610-777            TGSRFGKIDLGKTWNTGNFGPDAIAFTVDRPGISIAGACVYSGSGSYEYQLELLYDSHHSSHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPARGQIPAILYHCTPAG-----
A0A182FKJ0/1897-2067          TGSRFGKIDLGKTWNTGNFGPDAIAFTVDRAGISIAGACVYSGSGSYEYQLELLYDSHHSTHSHTHYSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPARGQIPAILYYSTPSGAA---
A0A182YB43/897-1064           TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRSGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVQLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPSRGQIPAILYYCTPAG-----
A0A182J9U7/888-1054           TGSRFGKIDLGKTWNTGNFGPDAIAFTVDRAGISIAGACVYSGSGSYEYQLELLYDSHHSSHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVSFRFYPCDLSFNGTTPARGQIPAILYYCTPV------
A0A182NZK4/493-660            TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRAGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPSRGQIPAILYYCTPAG-----
A0A182RTE7/1807-1974          TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRSGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPARGQIPAILYYCTPAG-----
A0A182JNI9/1901-2067          TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRAGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVQLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGSVTFRFYPCDLSFNGTTPARGQIPAILYYCTPV------
A0A182LV69/1796-1963          TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRSGISIVGACVYSGSGSYEYQLELLYDSHHSNHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPSRGQIPAILYYCTPAG-----
A0A182N2D3/1813-1979          TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRSGISIVGACVYSGSGSYEYQLELLYDSHHSSHSHT-YAHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPSRGQIPAILYYCTAA------
A0A182S7T2/1235-1402          TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRSGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAILLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPSRGQIPAILYYCTPAG-----
A0A182UVE3/1839-2005          TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRAGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPARGQIPAILYYCTPV------
A0A182WDH1/1766-1933          TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRSGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPSRGQIPAILYYCTPAG-----
A0A182TRI3/1900-2066          TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRAGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPARGQIPAILYYCTPV------
A0A182KL56/1898-2064          TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRAGISIVGACVYSGSGSYEYQLELLYDSHHSTHSHT-YSHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPARGQIPAILYYCTPV------
A0A182QJF9/856-1023           TGSRFGKVDLGKTWNTGNFGPDAIAFTVDRSGISIVGACVYSGSGSYEYQLELLYDSHHSSHSHT-YAHSHRWEVLESIVGSYDQTAVRQHMAELRFNRAVLLKENHRYALRLCSQGARTLSGDCGQSSLRGPCGTVTFRFYPCDLSFNGTTPSRGQIPAILYYCTPAG-----
A0A0P9BQK0/302-466            TGSRFARCDVSRTWNTGNFGPDAIAFSVDRPGVAIAGAMIYSGSGSYDYQLELLFDNTADLQPQ------HKWETLESVSGTYDQEIVHNDLAEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGT-QFHYYACDLSFNGTTPARGQIPCILYYSTPVKQDV--
A0A1W4VFP9/2022-2188          TGARFARCDVSRTWNTGNFGPDAIAFAVDRPGVAIAGAMVYSGSGSYDYQLELLYDNTADLQPQ------HKWETLESVSGTYDQDAVHNDLAEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGA-QFHFYACDLSFNGTTPARGQLPCILYYSTPMKQDGNS
B3NUW1/2016-2180              TGARFGRCDVSRTWNTGNFGPDAIAFAVDRPGVAIAGAMVYSGSGSYDYQLELLYDNTADLQPQ------HKWETLESVSGSYDQDAVHNDLAEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGA-QFHFYACDLSFNGTTPARGQLPCILYYSTPMKQDG--
A0A0R1EE00/1937-2103          TGARFARCDVSRTWNTGNFGPDAIAFAVDRPGVAIAGAMVYSGSGSYDYQLELLYDNTADLQPQ------HKWETLESVSGSYDQDAVHNDLAEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGA-QFHFYACDLSFNGTTPARGQLPCILYYSTPMKQDGNS
B4IJ87/2012-2178              TGARFARCDVSRTWNTGNFGPDAIAFAVDRPGVAIAGAMVYSGSGSYDYQLELLYDNTADLQPQ------HKWETLESVSGSYDQEAVHNDLAEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPEVRGPCGA-QFHFYACDLSFNGTTPARGQLPCILYYSTPMKQDGNS
#=GC scorecons                996996749667999999999999996999597696995899999997999999896555466620222297995999759799958965569967966684699959999999999999499959565699999625968969999999999699969599986984311100
#=GC scorecons_70             **_**_*_**_***************_***_**_*_**_*****************_____*_*______****_****_*****_***__********_*_****_*************_***_*___*******__****_****************_****_**_______
#=GC scorecons_80             **_**___*___**************_***_*__*_**_********_********______________*_**_***__*****_**____**__*___*__***_*************_***_*____*****___*_**_**********_***_*_****_**_______
#=GC scorecons_90             **_**___*___**************_***_*__*_**_********_********______________*_**_***__*_***_**____**__*___*__***_*************_***_*____*****___*_**_**********_***_*_****_**_______
//