CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 9: Cytohesin 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
51 |
O08967 (/ISS)
O08967 (/ISS)
O08967 (/ISS)
O08967 (/ISS)
P63035 (/ISS)
P97694 (/ISS)
P97694 (/ISS)
P97696 (/ISS)
Q2KI41 (/ISS)
Q76MY7 (/ISS)
(41 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
36 |
O08967 (/IPI)
O08967 (/IPI)
O08967 (/IPI)
O08967 (/IPI)
O43739 (/IPI)
O43739 (/IPI)
O43739 (/IPI)
P63034 (/IPI)
P63034 (/IPI)
P63035 (/IPI)
(26 more) |
Inositol 1,4,5 trisphosphate binding GO:0070679
Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate.
|
33 |
P63035 (/ISS)
Q2KI41 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
(23 more) |
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
23 |
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q99418 (/TAS)
(13 more) |
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
17 |
O43739 (/IDA)
O43739 (/IDA)
O43739 (/IDA)
P63034 (/IDA)
P63034 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
(7 more) |
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
8 | O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) Q80YW0 (/ISO) Q80YW0 (/ISO) Q9QX11 (/ISO) Q9QX11 (/ISO) |
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
7 | O08967 (/IDA) O08967 (/IDA) O08967 (/IDA) O08967 (/IDA) O43739 (/IDA) O43739 (/IDA) O43739 (/IDA) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
4 | O08967 (/ISS) O08967 (/ISS) O08967 (/ISS) O08967 (/ISS) |
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
4 | O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) |
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
2 | P97696 (/ISS) Q5ZIG9 (/ISS) |
Inositol 1,4,5 trisphosphate binding GO:0070679
Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate.
|
2 | P63034 (/IDA) P63034 (/IDA) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
1 | Q15795 (/NAS) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
|
14 |
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
(4 more) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
14 |
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
(4 more) |
Establishment of epithelial cell polarity GO:0090162
The specification and formation of anisotropic intracellular organization of an epithelial cell.
|
14 |
O43739 (/ISS)
O43739 (/ISS)
O43739 (/ISS)
P97694 (/ISS)
P97694 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
(4 more) |
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
|
11 |
A0A2R8QK04 (/IGI)
A0A2R8QTS0 (/IGI)
A2BHI2 (/IGI)
E7F2Q0 (/IGI)
F1QDR1 (/IGI)
F1R9I9 (/IGI)
F1RBL6 (/IGI)
Q08CQ5 (/IGI)
Q6PC26 (/IGI)
Q6PW01 (/IGI)
(1 more) |
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
|
9 | Q15438 (/TAS) Q15438 (/TAS) Q15438 (/TAS) Q15438 (/TAS) Q15438 (/TAS) Q15438 (/TAS) Q15438 (/TAS) Q15438 (/TAS) Q15438 (/TAS) |
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
|
9 | Q15438 (/IDA) Q15438 (/IDA) Q15438 (/IDA) Q15438 (/IDA) Q15438 (/IDA) Q15438 (/IDA) Q15438 (/IDA) Q15438 (/IDA) Q15438 (/IDA) |
Establishment of epithelial cell polarity GO:0090162
The specification and formation of anisotropic intracellular organization of an epithelial cell.
|
6 | O08967 (/IMP) O08967 (/IMP) O08967 (/IMP) O08967 (/IMP) Q9QX11 (/IMP) Q9QX11 (/IMP) |
Golgi vesicle transport GO:0048193
The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
|
5 | O08967 (/ISS) O08967 (/ISS) O08967 (/ISS) O08967 (/ISS) P97696 (/ISS) |
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
|
4 | O08967 (/IDA) O08967 (/IDA) O08967 (/IDA) O08967 (/IDA) |
Golgi vesicle transport GO:0048193
The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
|
4 | O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) |
Golgi vesicle transport GO:0048193
The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
|
3 | O43739 (/IMP) O43739 (/IMP) O43739 (/IMP) |
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
|
2 | P63034 (/ISO) P63034 (/ISO) |
Negative regulation of dendrite development GO:2000171
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development.
|
2 | P63034 (/ISO) P63034 (/ISO) |
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
|
2 | P97694 (/IDA) P97694 (/IDA) |
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
|
2 | P97694 (/IMP) P97694 (/IMP) |
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
|
2 | Q9QX11 (/ISO) Q9QX11 (/ISO) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | Q15795 (/TAS) |
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q15795 (/TAS) |
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
|
1 | Q5ZIG9 (/ISS) |
Negative regulation of dendrite development GO:2000171
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development.
|
1 | P63035 (/IMP) |
There are 34 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
33 |
O08967 (/IDA)
O08967 (/IDA)
O08967 (/IDA)
O08967 (/IDA)
O43739 (/IDA)
O43739 (/IDA)
O43739 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
(23 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
29 |
P63034 (/ISS)
P63034 (/ISS)
P63035 (/ISS)
P97694 (/ISS)
P97694 (/ISS)
P97696 (/ISS)
Q2KI41 (/ISS)
Q5ZIG9 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
(19 more) |
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
27 |
O43739 (/TAS)
O43739 (/TAS)
O43739 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
(17 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
27 |
O08967 (/IDA)
O08967 (/IDA)
O08967 (/IDA)
O08967 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
Q15438 (/IDA)
(17 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
27 |
O43739 (/TAS)
O43739 (/TAS)
O43739 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
Q15438 (/TAS)
(17 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
25 |
O08967 (/ISS)
O08967 (/ISS)
O08967 (/ISS)
O08967 (/ISS)
P97694 (/ISS)
P97694 (/ISS)
P97696 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
(15 more) |
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
|
25 |
O08967 (/ISS)
O08967 (/ISS)
O08967 (/ISS)
O08967 (/ISS)
P97694 (/ISS)
P97694 (/ISS)
P97696 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
(15 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
22 |
P63034 (/ISS)
P63034 (/ISS)
P63035 (/ISS)
Q2KI41 (/ISS)
Q5ZIG9 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
Q76MY7 (/ISS)
(12 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
14 |
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
(4 more) |
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
|
14 |
O43739 (/ISS)
O43739 (/ISS)
O43739 (/ISS)
P97694 (/ISS)
P97694 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
Q15438 (/ISS)
(4 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
14 |
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
Q99418 (/TAS)
(4 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
10 | O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) P63034 (/ISO) P63034 (/ISO) Q80YW0 (/ISO) Q80YW0 (/ISO) Q9QX11 (/ISO) Q9QX11 (/ISO) |
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
|
8 | O08967 (/IDA) O08967 (/IDA) O08967 (/IDA) O08967 (/IDA) P63034 (/IDA) P63034 (/IDA) Q9QX11 (/IDA) Q9QX11 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | O43739 (/IDA) O43739 (/IDA) O43739 (/IDA) Q9QX11 (/IDA) Q9QX11 (/IDA) |
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
|
5 | O43739 (/IDA) O43739 (/IDA) O43739 (/IDA) Q9QX11 (/IDA) Q9QX11 (/IDA) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
4 | O08967 (/IPI) O08967 (/IPI) O08967 (/IPI) O08967 (/IPI) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) |
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
4 | O08967 (/IDA) O08967 (/IDA) O08967 (/IDA) O08967 (/IDA) |
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
|
4 | O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) O08967 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | O43739 (/IDA) O43739 (/IDA) O43739 (/IDA) |
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
3 | O43739 (/ISS) O43739 (/ISS) O43739 (/ISS) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
2 | P63034 (/ISO) P63034 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P63034 (/ISO) P63034 (/ISO) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
2 | P97694 (/IDA) P97694 (/IDA) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
2 | P97694 (/IMP) P97694 (/IMP) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
2 | Q9QX11 (/ISO) Q9QX11 (/ISO) |
Extrinsic component of presynaptic membrane GO:0098888
The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
2 | P97694 (/IDA) P97694 (/IDA) |
Extrinsic component of presynaptic membrane GO:0098888
The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
2 | P97694 (/IMP) P97694 (/IMP) |
Extrinsic component of presynaptic membrane GO:0098888
The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
2 | Q9QX11 (/ISO) Q9QX11 (/ISO) |
Extrinsic component of postsynaptic specialization membrane GO:0098892
The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
2 | P63034 (/ISO) P63034 (/ISO) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | P63035 (/IDA) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | Q5ZIG9 (/ISS) |
Extrinsic component of postsynaptic specialization membrane GO:0098892
The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
1 | P63035 (/IDA) |