The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 573: Oxysterol-binding family protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P38713 (/IPI) P38713 (/IPI) P38713 (/IPI) P38713 (/IPI) P38713 (/IPI) P38713 (/IPI) P38713 (/IPI)
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
7 P38713 (/ISS) P38713 (/ISS) P38713 (/ISS) P38713 (/ISS) P38713 (/ISS) P38713 (/ISS) P38713 (/ISS)
Oxysterol binding GO:0008142
Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol.
7 P38713 (/ISS) P38713 (/ISS) P38713 (/ISS) P38713 (/ISS) P38713 (/ISS) P38713 (/ISS) P38713 (/ISS)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
7 P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA)
Sterol transfer activity GO:0120015
Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
7 P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Karyogamy involved in conjugation with cellular fusion GO:0000742
During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy.
7 P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI)
Invasive growth in response to glucose limitation GO:0001403
A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
7 P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
7 P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
7 P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI)
Pseudohyphal growth GO:0007124
A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate.
7 P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP)
Positive regulation of phosphatase activity GO:0010922
Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
7 P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA)
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
7 P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA)
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
7 P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP)
Maintenance of cell polarity GO:0030011
The maintenance of established anisotropic intracellular organization or cell growth patterns.
7 P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI)
Piecemeal microautophagy of the nucleus GO:0034727
Degradation of a cell nucleus by lysosomal microautophagy.
7 P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI) P38713 (/IGI)
ER to Golgi ceramide transport GO:0035621
The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.
7 P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP) P38713 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P38713 (/HDA) P38713 (/HDA) P38713 (/HDA) P38713 (/HDA) P38713 (/HDA) P38713 (/HDA) P38713 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA)
Cortical endoplasmic reticulum GO:0032541
A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.
7 P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA) P38713 (/IDA)
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