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CATH Superfamily 2.30.130.10

PUA domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PUA domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28: PUA domain containing protein

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Archaeosine synthase. [EC: 2.6.1.97]
L-glutamine + 7-cyano-7-carbaguanine(15) in tRNA + H(2)O = L-glutamate + archaeine(15) in tRNA.
  • In Euryarchaeota the reaction is catalyzed by ArcS.
  • In Crenarchaeota, which do not have an ArcS homolog, the reaction is catalyzed either by a homolog of EC 6.3.4.20 that includes a glutaminase domain (cf. EC 3.5.1.2), or by a homolog of EC 1.7.1.13.
  • The enzyme from the Euryarchaeon Methanocaldococcus jannaschii can also use arginine and ammonium as amino donors.
 1 Q58428
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