CATH Superfamily 2.20.28.200
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 1: NAD-dependent protein deacetylase sirtuin-6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q4FZY2 (/IPI) Q8N6T7 (/IPI) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | P59941 (/ISS) Q8N6T7 (/ISS) |
|
NAD-dependent histone deacetylase activity GO:0017136
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.
|
2 | P59941 (/ISS) Q8N6T7 (/ISS) |
|
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
|
2 | P59941 (/ISS) Q8N6T7 (/ISS) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | P59941 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | P59941 (/IGI) |
|
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
1 | Q8N6T7 (/TAS) |
|
NAD(P)+-protein-arginine ADP-ribosyltransferase activity GO:0003956
Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine.
|
1 | P59941 (/IDA) |
|
NAD(P)+-protein-arginine ADP-ribosyltransferase activity GO:0003956
Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine.
|
1 | Q8N6T7 (/ISS) |
|
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
|
1 | Q4FZY2 (/IDA) |
|
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
|
1 | P59941 (/ISO) |
|
NAD-dependent protein deacetylase activity GO:0034979
Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
|
1 | Q8N6T7 (/TAS) |
|
NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
|
1 | Q8N6T7 (/IDA) |
|
NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
|
1 | P59941 (/IMP) |
|
NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
|
1 | P59941 (/ISO) |
|
NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
|
1 | P59941 (/ISS) |
|
NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
|
1 | P59941 (/TAS) |
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
2 | Q4FZY2 (/ISS) Q8N6T7 (/ISS) |
|
Post-embryonic cardiac muscle cell growth involved in heart morphogenesis GO:0003247
The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart.
|
1 | Q4FZY2 (/IMP) |
|
Post-embryonic cardiac muscle cell growth involved in heart morphogenesis GO:0003247
The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart.
|
1 | P59941 (/ISO) |
|
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
|
1 | P59941 (/IMP) |
|
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | P59941 (/IDA) |
|
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | Q8N6T7 (/ISS) |
|
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | Q8N6T7 (/TAS) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P59941 (/IMP) |
|
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
|
1 | Q8N6T7 (/IDA) |
|
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
|
1 | P59941 (/ISO) |
|
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
|
1 | P59941 (/ISS) |
|
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
|
1 | P59941 (/IMP) |
|
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
1 | Q4FZY2 (/IEP) |
|
Positive regulation of chromatin silencing at telomere GO:0031940
Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres.
|
1 | Q8N6T7 (/IMP) |
|
Positive regulation of chromatin silencing at telomere GO:0031940
Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres.
|
1 | P59941 (/ISO) |
|
Positive regulation of telomere maintenance GO:0032206
Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
|
1 | Q8N6T7 (/IMP) |
|
Positive regulation of telomere maintenance GO:0032206
Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
|
1 | P59941 (/ISO) |
|
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
1 | P59941 (/IMP) |
|
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
|
1 | P59941 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P59941 (/IMP) |
|
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
|
1 | P59941 (/IMP) |
|
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
1 | P59941 (/IMP) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
1 | P59941 (/IMP) |
|
Positive regulation of chondrocyte proliferation GO:1902732
Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.
|
1 | Q8N6T7 (/IMP) |
|
Positive regulation of chondrocyte proliferation GO:1902732
Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.
|
1 | P59941 (/ISO) |
|
Positive regulation of telomeric heterochromatin assembly GO:1905549
Any process that activates or increases the frequency, rate or extent of telomeric heterochromatin assembly.
|
1 | Q8N6T7 (/IMP) |
|
Positive regulation of telomeric heterochromatin assembly GO:1905549
Any process that activates or increases the frequency, rate or extent of telomeric heterochromatin assembly.
|
1 | P59941 (/ISO) |
|
Positive regulation blood vessel branching GO:1905555
Any process that activates or increases the frequency, rate or extent of blood vessel branching.
|
1 | Q8N6T7 (/IMP) |
|
Positive regulation blood vessel branching GO:1905555
Any process that activates or increases the frequency, rate or extent of blood vessel branching.
|
1 | P59941 (/ISO) |
|
Positive regulation of vascular endothelial cell proliferation GO:1905564
Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.
|
1 | Q8N6T7 (/IMP) |
|
Positive regulation of vascular endothelial cell proliferation GO:1905564
Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.
|
1 | P59941 (/ISO) |
|
Positive regulation of stem cell proliferation GO:2000648
Any process that activates or increases the frequency, rate or extent of stem cell proliferation.
|
1 | P59941 (/IMP) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P59941 (/IDA) Q4FZY2 (/IDA) Q8N6T7 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | M0QZ09 (/IDA) Q8N6T7 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P59941 (/TAS) Q8N6T7 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P59941 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8N6T7 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P59941 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P59941 (/ISS) |
|
Nuclear telomeric heterochromatin GO:0005724
Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus.
|
1 | Q8N6T7 (/IDA) |
|
Nuclear telomeric heterochromatin GO:0005724
Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus.
|
1 | P59941 (/ISO) |
|
Nuclear telomeric heterochromatin GO:0005724
Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus.
|
1 | P59941 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q4FZY2 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P59941 (/ISO) |
