# STOCKHOLM 1.0 #=GF ID 1.10.510.10/FF/000651 #=GF DE Serine/threonine-protein kinase RAD53 #=GF AC 1.10.510.10/FF/000651 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 85.659 #=GS 4pdsB02/111-329 AC P22216 #=GS 4pdsB02/111-329 OS Saccharomyces cerevisiae S288C #=GS 4pdsB02/111-329 DE Serine/threonine-protein kinase RAD53 #=GS 4pdsB02/111-329 DR CATH; 4pds; B:276-494; #=GS 4pdsB02/111-329 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS 4pdsB02/111-329 DR GO; GO:0000077; GO:0003688; GO:0004672; GO:0004712; GO:0005515; GO:0005634; GO:0005829; GO:0006270; GO:0006281; GO:0006468; GO:0008104; GO:0009202; GO:0042326; #=GS 4pdsB02/111-329 DR EC; 2.7.12.1; #=GS Q585U8/92-279 AC Q585U8 #=GS Q585U8/92-279 OS Trypanosoma brucei brucei TREU927 #=GS Q585U8/92-279 DE Protein kinase, putative #=GS Q585U8/92-279 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; #=GS Q585U8/92-279 DR GO; GO:0004672; GO:0005524; GO:0005737; GO:0031981; GO:0097014; #=GS Q583H1/97-341 AC Q583H1 #=GS Q583H1/97-341 OS Trypanosoma brucei brucei TREU927 #=GS Q583H1/97-341 DE Protein kinase, putative #=GS Q583H1/97-341 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; #=GS Q583H1/97-341 DR GO; GO:0004672; GO:0005524; GO:0005737; GO:0005930; GO:0006468; #=GS A0A1D8PJZ1/253-470 AC A0A1D8PJZ1 #=GS A0A1D8PJZ1/253-470 OS Candida albicans SC5314 #=GS A0A1D8PJZ1/253-470 DE Serine/threonine-protein kinase RAD53 #=GS A0A1D8PJZ1/253-470 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida; Candida albicans; #=GS A0A1D8PJZ1/253-470 DR GO; GO:0030447; GO:0036171; GO:1900439; #=GS 4pdsA02/111-325 AC P22216 #=GS 4pdsA02/111-325 OS Saccharomyces cerevisiae S288C #=GS 4pdsA02/111-325 DE Serine/threonine-protein kinase RAD53 #=GS 4pdsA02/111-325 DR CATH; 4pds; A:276-490; #=GS 4pdsA02/111-325 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS 4pdsA02/111-325 DR GO; GO:0000077; GO:0003688; GO:0004672; GO:0004712; GO:0005515; GO:0005634; GO:0005829; GO:0006270; GO:0006281; GO:0006468; GO:0008104; GO:0009202; GO:0042326; #=GS 4pdsA02/111-325 DR EC; 2.7.12.1; #=GS 4pdpB02/111-331 AC P22216 #=GS 4pdpB02/111-331 OS Saccharomyces cerevisiae S288C #=GS 4pdpB02/111-331 DE Serine/threonine-protein kinase RAD53 #=GS 4pdpB02/111-331 DR CATH; 4pdp; B:276-496; #=GS 4pdpB02/111-331 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS 4pdpB02/111-331 DR GO; GO:0000077; GO:0003688; GO:0004672; GO:0004712; GO:0005515; GO:0005634; GO:0005829; GO:0006270; GO:0006281; GO:0006468; GO:0008104; GO:0009202; GO:0042326; #=GS 4pdpB02/111-331 DR EC; 2.7.12.1; #=GS 4pdpA02/111-329 AC P22216 #=GS 4pdpA02/111-329 OS Saccharomyces cerevisiae S288C #=GS 4pdpA02/111-329 DE Serine/threonine-protein kinase RAD53 #=GS 4pdpA02/111-329 DR CATH; 4pdp; A:276-494; #=GS 4pdpA02/111-329 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS 4pdpA02/111-329 DR GO; GO:0000077; GO:0003688; GO:0004672; GO:0004712; GO:0005515; GO:0005634; GO:0005829; GO:0006270; GO:0006281; GO:0006468; GO:0008104; GO:0009202; GO:0042326; #=GS 4pdpA02/111-329 DR EC; 2.7.12.1; #=GS P22216/276-496 AC P22216 #=GS P22216/276-496 OS Saccharomyces cerevisiae S288C #=GS P22216/276-496 DE Serine/threonine-protein kinase RAD53 #=GS P22216/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS P22216/276-496 DR GO; GO:0000077; GO:0003688; GO:0004672; GO:0004712; GO:0005515; GO:0005634; GO:0005829; GO:0006270; GO:0006281; GO:0006468; GO:0008104; GO:0009202; GO:0042326; #=GS P22216/276-496 DR EC; 2.7.12.1; #=GS E9AZF6/101-318 AC E9AZF6 #=GS E9AZF6/101-318 OS Leishmania mexicana MHOM/GT/2001/U1103 #=GS E9AZF6/101-318 DE Uncharacterized protein #=GS E9AZF6/101-318 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania mexicana; #=GS A0A1G4IG66/92-279 AC A0A1G4IG66 #=GS A0A1G4IG66/92-279 OS Trypanosoma equiperdum #=GS A0A1G4IG66/92-279 DE Protein kinase, putative #=GS A0A1G4IG66/92-279 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma equiperdum; #=GS C9ZJM0/92-279 AC C9ZJM0 #=GS C9ZJM0/92-279 OS Trypanosoma brucei gambiense DAL972 #=GS C9ZJM0/92-279 DE Protein kinase, putative #=GS C9ZJM0/92-279 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei gambiense; #=GS E9ACW7/101-317 AC E9ACW7 #=GS E9ACW7/101-317 OS Leishmania major #=GS E9ACW7/101-317 DE Uncharacterized protein #=GS E9ACW7/101-317 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania major species complex; Leishmania major; #=GS A4I349/105-323 AC A4I349 #=GS A4I349/105-323 OS Leishmania infantum #=GS A4I349/105-323 DE Uncharacterized protein #=GS A4I349/105-323 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; #=GS A0A3Q8IDK8/101-319 AC A0A3Q8IDK8 #=GS A0A3Q8IDK8/101-319 OS Leishmania donovani #=GS A0A3Q8IDK8/101-319 DE Protein kinase, putative #=GS A0A3Q8IDK8/101-319 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; #=GS Q6C079/271-472 AC Q6C079 #=GS Q6C079/271-472 OS Yarrowia lipolytica CLIB122 #=GS Q6C079/271-472 DE Serine/threonine-protein kinase RAD53 #=GS Q6C079/271-472 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia; Yarrowia lipolytica; #=GS Q75CE9/295-502 AC Q75CE9 #=GS Q75CE9/295-502 OS Eremothecium gossypii ATCC 10895 #=GS Q75CE9/295-502 DE Serine/threonine-protein kinase RAD53 #=GS Q75CE9/295-502 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium; Eremothecium gossypii; #=GS A0A367YN05/191-409 AC A0A367YN05 #=GS A0A367YN05/191-409 OS Candida viswanathii #=GS A0A367YN05/191-409 DE Serine/threonine-protein kinase RAD53 #=GS A0A367YN05/191-409 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida; Candida viswanathii; #=GS C5MJH1/251-469 AC C5MJH1 #=GS C5MJH1/251-469 OS Candida tropicalis MYA-3404 #=GS C5MJH1/251-469 DE Serine/threonine-protein kinase RAD53 #=GS C5MJH1/251-469 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida; Candida tropicalis; #=GS B9WDY3/253-470 AC B9WDY3 #=GS B9WDY3/253-470 OS Candida dubliniensis CD36 #=GS B9WDY3/253-470 DE Serine/threonine-protein kinase RAD53 #=GS B9WDY3/253-470 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida; Candida dubliniensis; #=GS A0A0L8R9S1/276-496 AC A0A0L8R9S1 #=GS A0A0L8R9S1/276-496 OS Saccharomyces eubayanus #=GS A0A0L8R9S1/276-496 DE Serine/threonine-protein kinase RAD53 #=GS A0A0L8R9S1/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces eubayanus; #=GS H0H1Y4/276-496 AC H0H1Y4 #=GS H0H1Y4/276-496 OS Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7 #=GS H0H1Y4/276-496 DE Serine/threonine-protein kinase RAD53 #=GS H0H1Y4/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae x Saccharomyces kudriavzevii; #=GS J8PY91/276-496 AC J8PY91 #=GS J8PY91/276-496 OS Saccharomyces arboricola H-6 #=GS J8PY91/276-496 DE Serine/threonine-protein kinase RAD53 #=GS J8PY91/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces arboricola; #=GS A0A0L8VFJ2/276-496 AC A0A0L8VFJ2 #=GS A0A0L8VFJ2/276-496 OS Saccharomyces sp. 'boulardii' #=GS A0A0L8VFJ2/276-496 DE Serine/threonine-protein kinase RAD53 #=GS A0A0L8VFJ2/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces sp. 'boulardii'; #=GS N1NVU5/276-496 AC N1NVU5 #=GS N1NVU5/276-496 OS Saccharomyces cerevisiae CEN.PK113-7D #=GS N1NVU5/276-496 DE Serine/threonine-protein kinase RAD53 #=GS N1NVU5/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS N1NVU5/276-496 DR EC; 2.7.12.1; #=GS C9ZN29/97-341 AC C9ZN29 #=GS C9ZN29/97-341 OS Trypanosoma brucei gambiense DAL972 #=GS C9ZN29/97-341 DE Protein kinase, putative #=GS C9ZN29/97-341 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei gambiense; #=GS A0A1G4IGS9/97-341 AC A0A1G4IGS9 #=GS A0A1G4IGS9/97-341 OS Trypanosoma equiperdum #=GS A0A1G4IGS9/97-341 DE Protein kinase, putative #=GS A0A1G4IGS9/97-341 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma equiperdum; #=GS A0A381MLM4/101-319 AC A0A381MLM4 #=GS A0A381MLM4/101-319 OS Leishmania infantum #=GS A0A381MLM4/101-319 DE Protein_kinase_-_putative #=GS A0A381MLM4/101-319 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; #=GS E9BJH2/101-319 AC E9BJH2 #=GS E9BJH2/101-319 OS Leishmania donovani BPK282A1 #=GS E9BJH2/101-319 DE Protein kinase, putative #=GS E9BJH2/101-319 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; #=GS A0A1D8NQ52/271-472 AC A0A1D8NQ52 #=GS A0A1D8NQ52/271-472 OS Yarrowia lipolytica #=GS A0A1D8NQ52/271-472 DE Serine/threonine-protein kinase RAD53 #=GS A0A1D8NQ52/271-472 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia; Yarrowia lipolytica; #=GS C4YQE1/253-470 AC C4YQE1 #=GS C4YQE1/253-470 OS Candida albicans WO-1 #=GS C4YQE1/253-470 DE Serine/threonine-protein kinase RAD53 #=GS C4YQE1/253-470 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida; Candida albicans; #=GS A0A367XQF1/248-466 AC A0A367XQF1 #=GS A0A367XQF1/248-466 OS Candida viswanathii #=GS A0A367XQF1/248-466 DE Serine/threonine-protein kinase RAD53 #=GS A0A367XQF1/248-466 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida; Candida viswanathii; #=GS C8ZIM5/276-496 AC C8ZIM5 #=GS C8ZIM5/276-496 OS Saccharomyces cerevisiae EC1118 #=GS C8ZIM5/276-496 DE Serine/threonine-protein kinase RAD53 #=GS C8ZIM5/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS G2WP29/276-496 AC G2WP29 #=GS G2WP29/276-496 OS Saccharomyces cerevisiae Kyokai no. 7 #=GS G2WP29/276-496 DE Serine/threonine-protein kinase RAD53 #=GS G2WP29/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS A6ZWA0/276-496 AC A6ZWA0 #=GS A6ZWA0/276-496 OS Saccharomyces cerevisiae YJM789 #=GS A6ZWA0/276-496 DE Serine/threonine-protein kinase RAD53 #=GS A6ZWA0/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS C7GJA5/276-496 AC C7GJA5 #=GS C7GJA5/276-496 OS Saccharomyces cerevisiae JAY291 #=GS C7GJA5/276-496 DE Serine/threonine-protein kinase RAD53 #=GS C7GJA5/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GS B3LKS4/276-496 AC B3LKS4 #=GS B3LKS4/276-496 OS Saccharomyces cerevisiae RM11-1a #=GS B3LKS4/276-496 DE Serine/threonine-protein kinase RAD53 #=GS B3LKS4/276-496 DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; Saccharomyces cerevisiae; #=GF SQ 36 4pdsB02/111-329 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITAFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLL---------------------------------------- Q585U8/92-279 ------LNYIKRRGPLPEGVTIQVVRQLLEALAHLHGRGVMHRDIKAENILIR----EPTEGRKPLGRVCICDYGFATCSTPT----NECVGSPGYCAPEIALIGITQ-GPKADENGYCYDEKCDIWSLGVTTYAMLSGQLPFTGGTPTDVFKSILRDSVPFSSPTWGNVSHEAKKFVLYLMTFKASNRPSARAALGHPWLV----------V---------------------------------------------------------- Q583H1/97-341 --GGMVFDRIAELSHYDEKIAADLVRNVLSGLVHIHSRGIIHRDLKPENLLLR--PQRDSDDTSWLSDVCISDFGLAS-TGPG----KACCGTAKYIAPEVVKVGYYG-TVKGT-----YDNKCDVWSLGVITFVLLSGKMPFYGATHREIFRRIVDGKWSFGGPIWNTISLMGKSFIRSCLTRDPAKRPSARELLNHPWIT----------DD-QPDKHLGESIEEIRSLTAITKLRGATAVIRTSHEMLGGIDSCASFTKHLRHKDKLS A0A1D8PJZ1/253-470 VPGGDLMDFVAANGAIGEDATQVITKQILEGIAYVHNLGISHRDLKPDNILIM---------QDDPILVKITDFGLAK-FSDNSTFMKTFCGTLAYVAPEVITGKYGS-SQMESQQKDNYSSLVDIWSLGCLVYVLLTSHLPFNGKNQQQMFAKIKRGEFHEAPLNSYDISEDGRDFLQCCLQVNPKLRMTAAEALKHKWLQ----DLY-EEDS-VKSLSLSQSQSQQS-----RKIDNG------------------------------- 4pdsA02/111-325 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITAFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQ-------------------------------------------- 4pdpB02/111-331 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITAFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLLEN-------------------------------------- 4pdpA02/111-329 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITAFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLL---------------------------------------- P22216/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLLEN-------------------------------------- E9AZF6/101-318 --GGMLFDRIIELKHYSESNASVLVRNVLSGLAHIHSKGVIHRDLKPENLLLRYAASPLTSPNSNLTDVCLADFGLAG-YVPS----TTCCGSPSYIAPEVISVGYYR-TRKEP-----YDAKCDIWSIGVITYILLSGKMPFHGNSFKETFELVVSNRWSFSRDVWASVTPAAKDFIQACLTYDPVERPTAQELLQHLWLA----------NE-QPHVHLGRSLESLRDLTK-KKVKAAVRV---------------------------- A0A1G4IG66/92-279 ------LNYIKRRGPLPEGVTIQVVRQLLEALAHLHGRGVMHRDIKAENILIR----EPTEGRKPLGRVCICDYGFATCSTPT----NECVGSPGYCAPEIALIGITQ-GPKADENGYCYDEKCDIWSLGVTTYAMLSGQLPFTGGTPTDVFKSILRDSVPFSSPTWGNVSHEAKKFVLYLMTFKASNRPSARAALGHPWLV----------V---------------------------------------------------------- C9ZJM0/92-279 ------LNYIKRRGPLPEGVTIQVVRQLLEALAHLHGRGVMHRDIKAENILIR----EPTEGRKPLGRVCICDYGFATCSTPT----NECVGSPGYCAPEIALIGITQ-GPKADENGYCYDEKCDIWSLGVTTYAMLSGQLPFTGGTPTDVFKSILRDSVPFSSPTWGNVSHEAKKFVLYLMTFKASNRPSARAALGHPWLV----------V---------------------------------------------------------- E9ACW7/101-317 --GGMLFNRIVELQHYSESNASVLVRNVLSGLAHIHSRGVIHRDLKPENLLLRYAASPSTSPNSNLTDVCLADFGLAG-YVPS----TTCCGSPSYIAPEVISVGYYR-TRKEP-----YDSKCDIWSIGVVTYILLSGKMPFHGNSFRETFELVVGNRWSFSSDTWASVTPTAKDFIEACLTYDPVERPTALELLQHPWLA----------NE-QPHVHLGRSLESLRSLTK-TKVKAAVR----------------------------- A4I349/105-323 --GGMLFDRIIELKHYSESNASVLVRNVLSGLAHIHSRGVIHRDLKPENLLLRYAASPSTSPNSNLTDVCLADFGLAG-YVPS----TTCCGSPSYIAPEVISVGYYR-TRKEP-----YDAKCDIWSIGVITYILLSGKMPFHGNSFKETFELIVSNRWSFNSDTWASVTPTAKDFIQACLTYDPVERPTALELLQHPWLA----------NE-QPHVHLGRSLESLRDLTK-KKVKAAVQVF--------------------------- A0A3Q8IDK8/101-319 --GGMLFDRIIELKHYSESNASVLVRNVLSGLAHIHSRGVIHRDLKPENLLLRYAASPSTSPNSNLTDVCLADFGLAG-YVPS----TTCCGSPSYIAPEVISVGYYR-TRKEP-----YDAKCDIWSIGVITYILLSGKMPFHGNSFKETFELIVSNRWSFNSDTWASVTPTAKDFIQACLTYDPVERPTALELLQHPWLA----------NE-QPHVHLGRSLESLRDLTK-KKVKAAVQVF--------------------------- Q6C079/271-472 --NGDLMDFISEFGAIPEFVTREIVKQVLETVRDFHAMGVSHRDIKPDNILVF---------QDDPVIVKVSDFGLAK-VTQD-SILNTFCGTMAYIAPEILLSR-ER-RKANSADPGCYSNLVDMWSIGCLCYVLATGYLPFDGTSHEAIVKAITAGTYCQKPLNDFNISPMGRDFIKCLLTVDPEERPSAIQILRHPWFS----------DD-SVRLRVTEGEAGD------------------------------------------- Q75CE9/295-502 VSGGDLMDFVAAHGSVGEDAGREITRQILEAVRYIHEQGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-IQDNTTFMKTFCGTLAYVAPEVIGGKNPE---GNGANGNLYSSLVDMWSIGCLVYVILTGHLPFSGSTQEQLYKQIANGSYHEGPLKDYRISDEARDFIDSLLQINPVDRLTAERALQHPWLH----PCT-SIGA-EIAVSLSQSLSQ-------------------------------------------- A0A367YN05/191-409 VPGGDLMDFVAANGAIGEDATQVITKQILEGIAYVHKMGISHRDLKPDNILIM---------QDDPILVKITDFGLAK-FSDNLTVMKTFCGTLAYVAPEVITGKFGS-SQMELQQREDYSSLVDMWSLGCLVYVLLTSHLPFNGKNQQQMFAKIKRGEFHEAPLNSYDISEEGRDFLESCLQVNPKLRLTAEEALNHKWLQ----DAYTEEDSPPKSLSLSQSQSQQS-----RKIEN-------------------------------- C5MJH1/251-469 VPGGDLMDFVAANGAIGEDATQVITKQILEGIAYVHKMGISHRDLKPDNILIA---------QDDPILVKITDFGLAK-FSDNSTVMKTFCGTLAYVAPEVITGKFGS-SQMESQQKDNYSSLVDIWSLGCLVYVLLTSHLPFNGKNQQQMFAKIKRGEFHEAPLNSYDISEDGRDFLECCLQVNPKLRMTAEEALKHKWLQ----DVYTDDDS-LKSLSLSQSQSQQS-----RKIENG------------------------------- B9WDY3/253-470 VPGGDLMDFVAANGAIGEDATQVITKQILEGIAYVHNLGISHRDLKPDNILIM---------QDDPILVKITDFGLAK-FSDNSTFMKTFCGTLAYVAPEVITGKYGS-SQMESQQKDNYSSLVDIWSLGCLVYVLLTSHLPFNGKNQQQMFAKIKRGEFHEAPLNSYDISEDGRDFLQCCLQVNPKLRMTAAEALKHKWLQ----DLY-EEDS-VKSLSLSQSQSQQS-----RKIDNG------------------------------- A0A0L8R9S1/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILEAVKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDSSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRLTAAKALGHPWIKMNPLVPQ-SDGD-FSQISLSQSLSQQKILEN-------------------------------------- H0H1Y4/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILAAVKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDSSVSPDECEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDLLLQVDPNNRLTAAKALDHPWIKMNPFGSQ-SYGD-FSQISLSQSLSQQKILEN-------------------------------------- J8PY91/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILTAVKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDSSVSPEEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNDRLTAAKALDHPWIKMNPFGSQ-SFGD-FSQISLSQSLSQQKILEN-------------------------------------- A0A0L8VFJ2/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLLEN-------------------------------------- N1NVU5/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLLEN-------------------------------------- C9ZN29/97-341 --GGMVFDRIAELSHYDEKIAADLVRNVLSGLVHIHSRGIIHRDLKPENLLLR--PQRDSDDTSWLSDVCISDFGLAS-TGPG----KACCGTAKYIAPEVVKVGYYG-TVKGT-----YDNKCDVWSLGVITFVLLSGKMPFYGATHREIFRRIVDGKWSFGGPIWNTISLMGKSFIRSCLTRDPAKRPSARELLNHPWIT----------DD-QPDKHLGESIEEIRSLTAITKLRGATAVIRTSHEMLGGIDSCASFTKHLRHKDKLS A0A1G4IGS9/97-341 --GGMVFDRIAELSHYDEKIAADLVRNVLSGLVHIHSRGIIHRDLKPENLLLR--PQRDSDDTSWLSDVCISDFGLAS-TGPG----KACCGTAKYIAPEVVKVGYYG-TVKGT-----YDNKCDVWSLGVITFVLLSGKMPFYGATHREIFRRIVDGKWSFGGPIWNTISLMGKSFIRSCLTRDPAKRPSARELLNHPWIT----------DD-QPDKHLGESIEEIRSLTAITKLRGATAVIRTSHEMLGGIDSCASFTKHLRHKDKLS A0A381MLM4/101-319 --GGMLFDRIIELKHYSESNASVLVRNVLSGLAHIHSRGVIHRDLKPENLLLRYAASPSTSPNSNLTDVCLADFGLAG-YVPS----TTCCGSPSYIAPEVISVGYYR-TRKEP-----YDAKCDIWSIGVITYILLSGKMPFHGNSFKETFELIVSNRWSFNSDTWASVTPTAKDFIQACLTYDPVERPTALELLQHPWLA----------NE-QPHVHLGRSLESLRDLTK-KKVKAAVQVF--------------------------- E9BJH2/101-319 --GGMLFDRIIELKHYSESNASVLVRNVLSGLAHIHSRGVIHRDLKPENLLLRYAASPSTSPNSNLTDVCLADFGLAG-YVPS----TTCCGSPSYIAPEVISVGYYR-TRKEP-----YDAKCDIWSIGVITYILLSGKMPFHGNSFKETFELIVSNRWSFNSDTWASVTPTAKDFIQACLTYDPVERPTALELLQHPWLA----------NE-QPHVHLGRSLESLRDLTK-KKVKAAVQVF--------------------------- A0A1D8NQ52/271-472 --NGDLMDFISEFGAIPEFVTREIVKQVLETVRDFHAMGVSHRDIKPDNILVF---------QDDPVIVKVSDFGLAK-VTQD-SILNTFCGTMAYIAPEILLSR-ER-RKANSADPGCYSNLVDMWSIGCLCYVLATGYLPFDGTSHEAIVKAITAGTYCQKPLNDFNISPMGRDFIKCLLTVDPEERPSAIQILRHPWFS----------DD-SVRLRVTEGEAGD------------------------------------------- C4YQE1/253-470 VPGGDLMDFVAANGAIGEDATQVITKQILEGIAYVHNLGISHRDLKPDNILIM---------QDDPILVKITDFGLAK-FSDNSTFMKTFCGTLAYVAPEVITGKYGS-SQMESQQKDNYSSLVDIWSLGCLVYVLLTSHLPFNGKNQQQMFAKIKRGEFHEAPLNSYDISEDGRDFLQCCLQVNPKLRMTAAEALKHKWLQ----DLY-EEDS-VKSLSLSQSQSQQS-----RKIDNG------------------------------- A0A367XQF1/248-466 VPGGDLMDFVAANGAIGEDATQVITKQILEGIAYVHKMGISHRDLKPDNILIM---------QDDPILVKITDFGLAK-FSDNLTVMKTFCGTLAYVAPEVITGKFGS-SQMELQQREDYSSLVDMWSLGCLVYVLLTSHLPFNGKNQQQMFAKIKRGEFHEAPLNSYDISEEGRDFLESCLQVNPKLRLTAEEALNHKWLQ----DAYTEEDSPPKSLSLSQSQSQQS-----RKIEN-------------------------------- C8ZIM5/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLLEN-------------------------------------- G2WP29/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLLEN-------------------------------------- A6ZWA0/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLLEN-------------------------------------- C7GJA5/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLLEN-------------------------------------- B3LKS4/276-496 VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE---------QDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ-SYGD-FSQISLSQSLSQQKLLEN-------------------------------------- #=GC scorecons 2166465747553544494454465766945646695497599979779696400000010055454495757897940334512225657965596999763453340444532222195555969959555866867579949454454653835644444544334774467697444854673494693559496963000011101144023334644634433131101111110000000000000000000000000000000 #=GC scorecons_70 __**___*_*_______*_____*_****____***__**_***********________________*_*_*****___________*_***__*_*****_________________*____****_*___**_*_*_***_*______*__*______________**__*****___*__**__*_**___*_***____________________*__*_______________________________________________ #=GC scorecons_80 _______*_________*_______*__*______*__**_******_*_*_________________*___*****_____________**___*_****__________________*____*_**_*___*__*_*__**_*_________*______________*______*____*___*__*__*___*_*_*_______________________________________________________________________ #=GC scorecons_90 _________________*__________*______*__*__***_*__*_*_________________*____**_*______________*___*_***___________________*____*_**_*___*__*____**_*_________*_____________________*____*______*__*___*_*_*_______________________________________________________________________ //